Biomarkers of oocyte quality

ABSTRACT

The present technology relates to biomarkers of oocyte quality and oocyte quality dealine, as well as methods in connection with such biomarkers, including method of determining the quality of an oocyte, kits for the same, and libraries, reproductive aging gene expression profiles and profile sets with information relating the same.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. Provisional Application No.62/089,604 filed Dec. 9, 2014, and U.S. Provisional Application No.62/254,356 filed Nov. 12, 2015, the contents of both of which are herebyincorporated by reference.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

This invention was made with government support under Grant No. OD004402awarded by the National Institutes of Health. The government has certainrights in the invention.

BACKGROUND

The present technology relates to biomarkers of oocyte quality andoocyte quality decline, as well as methods in connection with suchbiomarkers.

The functions of the female reproductive system are known to declinewith age. One major factor in decreased fertility is the decline of thequality of the eggs (oocytes) produced by the ovaries as a woman ages.Decline of quality of oocytes and ovarian follicles generally beginssometime in the 30 s for most women and eventually leads to menopause,in most cases between ages 45 and 55.

In certain instances, it can be useful and desirable to determine thequality of an oocyte; for example, when a woman is seeking informationabout her level of fertility and chances of conception; or when aclinician seeks such information in association with assistedreproductive technologies (ART). Current methods are limited to thedetermination of oocyte quantity, not quality; furthermore, such methodsare generally time consuming, expensive and require destruction of theoocyte itself. For a female subject who may be concerned about decliningegg reserve and quality as she ages, a serious disadvantage isassociated with any method or kit that requires the destruction of anoocyte in order to measure the subject's chances of conception. Further,since known methods are invasive, currently they can be performed onlyby medical personnel in a clinic or hospital setting; a woman cannotdetermine oocyte quality on her own. Thus, the current limitation of thetechnology to invasive methods has prevented the widespread adoption ofdiagnostic tests.

Thus, there is a need for methods and systems that can accuratelypredict or determine the quality of an oocyte, namely methods that arenon-invasive, easy for patients to use, affordable and provide rapid andaccurate results.

SUMMARY OF THE DISCLOSED TECHNOLOGY

In certain embodiments, the present technology is directed to a methodof determining the quality of an oocyte in the body of a human withoutdisturbing or destroying the oocyte, the method comprising:

(a) obtaining a cell sample from a female subject, wherein the cellsample does not include the oocyte;

(b) measuring a characteristic of a gene or pathway indicative of oocytequality in the cell sample; and

(c) predicting or determining the quality of the oocyte based on thecharacteristic of the gene or pathway.

In certain embodiments, the present technology is directed to a methodof predicting the quality of an oocyte in the body of a mammal withoutdisturbing or destroying the oocyte, the method comprising the steps of:

(a) obtaining a cell sample from the mammal, wherein the cell sampledoes not include the oocyte;

(b) conducting an RT-PCR assay or an ELISA assay on the cell sampleusing a primer for a gene known to be correlated with aging, andcomparing the result with a known value obtained from a library of genesknown to be correlated with decreased oocyte quality; and

(d) predicting the likelihood of oocyte viability based on (b).

In certain embodiments, the present technology is directed to a kit forpredicting a woman's oocyte quality without the need for disturbing ordestroying an oocyte, or of measuring a characteristic that correlateswith the quality of an oocyte, the kit comprising:

(a) a collection container for collecting a cell sample obtained fromthe woman's body, wherein the cell sample does not include an oocyte;

(b) a testing assay comprising RT-PCR or ELISA, wherein the testingassay measures a characteristic of a gene, pathway or transcriptionalprofile characteristic of the cell sample, and wherein thecharacteristic indicates the likely quality of an oocyte; and

(c) a visual indicator visible to the woman, the visual indicatorproviding information regarding the predicted quality of the oocyte.

In certain embodiments, the present technology is directed to a methodof producing a library of genes as markers of oocyte quality. Such amethod may comprise the steps of correlating a test gene with aquantitative and measured characteristic of oocyte quality, listing thecorrelation in the library; comparing a measured characteristic of agene provided by a patient with that listed in the library; anddetermining the quality of an oocyte of a patient based on thecomparison. In certain embodiments, the technology herein contemplates amethod of producing a library of genes as markers of oocyte quality, themethod comprising the steps of:

(a) gathering expression data from cells of women in a particular agerange;

(b) calculating an average gene expression for each gene at each age inthe range by averaging the expression for that gene in a window of agiven period of time;

(c) comparing the average gene expression of (b) to an “age vector” toindicate which genes change most with age; and

(d) calculating a FisherZ score, thereby identifying the genes at thetail ends of the distribution as indicators of biological age.

In certain embodiments, the present technology is directed to areproductive aging gene expression profile; and a method of developing areproductive aging gene expression profile and one or more candidatemarkers of reproductive success.

In certain embodiments, the present technology is directed to a methodof producing a profile set as an indicator of oocyte quality. Suchmethods discussed herein may be done, for example, with any gene,pathway, or transcriptional profile, or with a library of the same.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1a is a graph showing the prevalence of Down syndrome andinfertility in a typical female human as a function of age. FIG. 1b is agraph showing the aging profile of oocytes in a typical female human asa function of age.

FIG. 2 shows age-dependent gene expression changes in blood from womenaged 20 to 50, as a “heat map” which shows on a macro level relativechanges.

DETAILED DESCRIPTION

As used herein, “female subject” and “patient” are used interchangeablyto refer to the individual whose oocyte quality is desired to bedetermined. As discussed herein, a “cell sample” refers to one or morecell from any part of the patient's body, which is desired to be testedin order to perform the diagnostic and scientific methods discussedherein. In various embodiments, a cell sample in accordance with thetechnology herein may be extracted from any of the following: blood,skin, hair, urine, saliva, sweat, vaginal secretion, any other fluid(including but not limited to intracellular or extracellular fluid,interstitial fluid, lymphatic fluid or transcellular fluid,cerebrospinal fluid, mucus or phlegm).

Oocyte quantity (the number of viable oocytes produced by a woman, thetotality of which is determined long before the onset of puberty) andquality (the likelihood that the oocyte can be successfully fertilizedand lead to pregnancy) are two factors of paramount importance inpredicting fertility and the likelihood of carrying a pregnancy to termin a female. A woman's oocyte quality is generally predicted to declineafter a certain age, until she reaches menopause and her ovaries stopreleasing oocytes entirely. That is, with rising maternal age, and as awoman's oocytes age as well, a woman loses the ability to reproduce, andthe children she may have are at greater risk for birth defects,chromosomal abnormalities, miscarriage and other problems. These defectsstart to arise when the woman is in her mid-30s and increase through the40s, about a decade prior to menopause (the average age of menopause is51), and are caused by declining oocyte quality.

Specifically, age-related reproductive decline is characterized byincreasing levels of defects in oocyte chromosomal segregation, cellcycle arrest, and oocyte mitochondrial function and morphology, amongother factors. Changes in gene expression correlate with these oocyteand egg quality changes, and have been shown in aging human and mouseoocytes. Our work in particular on C. elegans oocyte aging, discussed ingreater detail below, has highlighted the evolutionary conservation ofoocyte quality components. These components, particularly regulators ofchromosome segregation fidelity, have been shown to be required foroocyte function and prevention of aneuploidy in worm and mammalianoocytes, and increased fidelity extends reproductive span.

However, despite the great concern about this problem, the exact age atwhich any particular woman might have problems is not known, and nodiagnostic assay currently exists that can predict long-term age-relatedfertility status. Thus, a woman who is trying to conceive has limitedoptions for determining the quality of an oocyte any given month or forpredicting future success.

Current methods, such as endocrine tests of the ovarian reserve (oocytenumber) predictors follicle stimulating hormone (FSH) and anti-mullerianhormone (AMH), have only immediate, short-term predictability of successwith assisted reproductive technologies (ART) such as intrauterineinsemination (IUI) in vitro fertilization (IVF), gamete intrafallopiantube transfer (GIFT) and zygote intrafallopian tube transfer (ZIFT).However, such tests cannot generally predict long-term prospectivefertility. Similarly, known methods involving transvaginal ultrasoundmeasurements of antral follicle count (AFC) focus on assessing oocytenumber. However, oocyte quality, not quantity, is the limiting factor inmost age-related fertility decline. In particular, aneuploidies(aberrations in chromosome numbers) and cell cycle arrest/maintenancefailures can be a cause of infertility, birth defects, and miscarriage.Morphological assessments are too gross to identify other importantmeasures of quality, such as the levels of particular maternal RNAs thatregulate processes in the oocyte. Finally, current measures of oocytequality require invasive approaches, and the assessment itself candestroy the oocyte in question, further limiting a woman's number ofhealthy oocytes and potentially requiring a larger pool of donatedoocytes for treatment.

By contrast, bodily fluids such as blood and urine are easy to obtain,and in the case of blood, PBMCs (peripheral blood mononuclear cells)have been shown to provide information about the physiological state ofother tissues, including ovarian cells. In fact, a recent study byGielchinsky et al. in 2008 showed that PBMC expression analysis was ableto identify candidate genes up- and down-regulated in women whodelivered babies after spontaneous pregnancy at ?45 years of age. Thesecandidate genes included markers of ovarian function, apoptosis,ubiquitination, energy production, and insulin/IGF-1 signaling—the samepathway that we showed extends reproductive span in C. elegans. Whilethese factors are good candidates for age-related oocyte qualitybiomarkers in blood, our work can establish a timecourse for oocyteaging biomarkers in blood throughout the reproductive aging years,allowing us to identify and verify a set of biomarker genes to use fordiagnostic purposes.

A diagnostic of oocyte quality, particularly a non-invasive measure,would be in high demand at several levels: clinics conducting assistedreproductive technology methods such as IVF would like this informationbefore embarking on ART approaches to improve their success rates,egg-freezing companies could use such a diagnostic to predict thesuccess of use of eggs they have frozen, and women could use the data tomake informed decisions about their reproductive lives in a manner thatis minimally invasive and highly convenient. Thus, in certainembodiments, the technology herein identifies, and permits health careworkers or patients to identify biomarkers of oocyte quality in blood orother bodily fluids, as well as the development of a reliable long-termdiagnostic of fertility.

Aging studies have been performed on Caenorhabditis elegans, a worm thathas been developed as a model of reproductive aging for humans. Asdemonstrated by data from C. elegans and mice, certain genes in anorganism are related to the quality of the oocytes of the organism.

In certain embodiments herein, the quality of an oocyte can bedetermined by, for example, measuring certain factors and comparingthose factors with known values of oocytes of known age. Certain methodsherein permit an investigator (including a health care worker or thesubject herself) to determine or predict the quality of an oocyte in thebody of a human without disturbing (e.g., touching, sampling, moving oraltering) or destroying the oocyte itself, and without taking it out ofthe human's body, e.g., in vivo. Thus, in certain embodiments, theoocyte itself can be evaluated (or its characteristics determined andpredicted) without harming the oocyte, and the oocyte can itselfsubsequently be fertilized and lead to a successful pregnancy.

In certain embodiments, the present technology relates to novel methodsfor assessing or predicting the quality of oocytes without the need fordisturbing or destroying the oocytes themselves. These methods are basedat least in part on the discovery that genes in C. elegans, whichdisplay changes as oocytes age, are the same genes as those found inmammals; further, even if no directly associated genes were located,mammalian genes with similar functions to the C. elegans genes werelocated. The C. elegans research also revealed data regarding thecharacteristics of gene expression in mutant C. elegans with longreproductive spans. Many of these genes are involved in chromosomesegregation, spindle localization, chromosome organization, DNA damageresponse and repair, and mitochondrial processes such as ATP metabolism.These genes, therefore, are good biomarkers for oocyte quality fromoocytes.

In certain embodiments, the present technology is directed to theexploitation of the non-invasive nature of blood biomarkers, orbiomarkers from other bodily fluids. In certain embodiments, the presenttechnology is directed to the development of single-gene markers asbiomarkers; in other embodiments, the present technology is directed toprofiles or multiple-gene markers, rather than single-gene markers, asbiomarkers.

Table 1 shows pathways that Shown in the Table 1 is a summary of certaingenes and pathways that have previously been identified as being ofpotential interest for human (H), mouse (M) and worm (W), in connectionwith applications of the present technology.

Genes from oocyte array studies (homologs) Gene Ontology Gene Worm (upcategory count in sma-2) Mouse Human Cell cycle mitosis ^(HMW) 8cyb-1(Ccnb2), Ccnb2, Ccna2, CCNA2, CCNG1, cyb-3(Ccnb3), Cdc16 CDK7cdc-25.2(Cdc25a), cki-1* Chromosome segregation, org'n chromosome 7smc-4(Smc4l1), klp-7, Smc4l1, Nin, Smc3l1, segregation ^(HMW) frm-5Kif3b, Bub1 BUB1B, BUB3 spindle localization ^(M) 4 gad-1, mes-1, par-3Hook1, Nin, Rnf19 spindle organization ^(M) 3 mbk-2, sur-6, goa-1 Tuba2,Tubd1, Pcnt2 chromosome 12 spr-5, nurf-1, hpl-1, Hdac2, organization^(MW) hil-2 Morf4l2, Rbbp7 DNA damage response and repair response toDNA 4 mlh-1(MLH1), clk-2, Msh-3, Exo1, MBD4 damage stim. ^(M) pme-5,uev-2* Shprh (interacts with MLH1), ATR, NBS1 Proteolytic pathwayproteolysis ^(HM) 19 ubc-1(Ube2a), Ube2a, Ubc, USP1, CTSC,ubc-2(Ube2d1), ulp-1 Usp1 GRP58 Energy pathway, mitochondrial fn. ATPmetabolic process ^(M) 7 pmr-1(Atp2c1), (Atp6v1a), Atp2c1,tat-5(Atp9b)vha-13 Atp6v1d, Atp5b ATP binding ^(HMW) 42 pgp-7(Abcb11),mrp-2 Abcb6, Abcf3, ABCC4, (Abcc3), Cct2 SMARCA5, SUV3 psa-4(SMARCA5),pdk-1, akt-2 Cell signalling and communication intracellular signaling11 cdc-42(RHO GTPase), Rhoh, Kras2, ATF1, CREB1, cascade ^(HMW) vhp-1,sel-12 Mek1 CLK1 cell-cell signaling ^(MW) 5 unc-18, ace1, cab-1 Gja7,Shroom3, Mmp2 Protein transport protein transport ^(HMW) 11arf-1.1(Arf1), arl-13 Arf1, Arl4, Rab1 ARF4, ARF6, (Arl13b) RAB11arab-6.2 (Rab6) Transcription 19 hlh-1, efI-1, spt-5 Phtf1, Crsp6, PHTF1,NFE2L2, regulation ^(HMW) Lhx8 ElF2AK2 Reproductive process oogenesis^(M) 5 hrp-1, goa-1, fem-3 Nalp5, Padi5, Nalp9a oyiposition ^(W) 15unc-84, cki-1, mtm-3 Other cell death ^(MW) 7 ced-1, ced-8, crn-4Tnfaip8, Mdm4, BcI2110 cell differentiation ^(W) 24 par-1, eor-2, !in-28cell adhesion ^(mw) 6 epi-1(Lama2), Lama2, Cdh2, hmr-1(Cdh11), Pcdhb17cdh-3(Cdh23)

In certain embodiments, the genes and pathways further include any ofthe following:

Genes in the IIS pathway: RHEB2, 14-3-3 beta/alpha, UDP-D-glucosecytosol, IGF-2, p90Rsk, MEK2 (MAP2K2), c-Myc, IRS-1, PtdIns(3,4,5)P3,PtdIns(4,5)P2, IKK (cat), Erk (MAPK1/3), Hamartin, c-Raf-1, AKT (PKB),PI3K cat class IA, ASK1 (MAP3K5), c-Raf-1, 14-3-3 epsilon, PTEN, 14-3-3zeta/delta, IGF-1, PI3K reg class IA, p70 S6 kinase1, CREB1, GSK3alpha/beta, Cyclin D, 3.1.3.67, MEK1 (MAP2K1), Bcl-XL, GRB2, PDK(PDPK1), mTOR, Caspase-9, FOXO3A, Tuberin, 2.7.1.137, Glycogen, I-kB,BAD, 4E-BP1, IGF-1 receptor, H-Ras, IBP, IKK-alpha, GYS1, 2.4.1.11,RPS6, She, SOS, NF-kB, Elk-1

Akt pathway (overlaps with IIS): MDM2, HGF receptor (Met), GYS1,2.7.1.153, Bcl-XL, IKK-alpha, GAB1, Bax, Hamartin, PI3K cat class IA,BAD, IRS-1, PtdIns(3,4,5)P3, PtdIns(4,5)P2, 4E-BPI, mTOR, Caspase-9,FasL(TNFSF6), GSK3 alpha/beta, p21, NF-kB, IGF-1 receptor, RHEB2, PCNA,PI3K reg class IA, PTEN, PP2A catalytic, PDK (PDPK1), Cyclin D3, p53,3.1.3.67, p27KIP1, AKT(PKB), Tuberin, RPS6, p70 S6 kinase1, c-Myc,HSP90, Cyclin D, IKK (cat), Bim, FOXO3A, I-kB

PTEN (overlaps with IIS): RHEB2, MEK1(MAP2K1), PtdIns(4,5)P2, Caspase-3,PDK (PDPK1), 3.1.3.67, ERK1/2, c-Jun, IGF-1, mTOR, PCNA, MEK2(MAP2K2),FOXO3A, p53, p21, FAK1, p130CAS, c-Cbl, Shc, GSK3 beta, BAD, Paxillin,EGF, PI3K reg class IA, H-Ras, MAGI-2, SOS, PTEN, c-Src, Tcf(Lef),alpha-5/beta-1 integrin, IRS-1, PI3K cat class IA, Beta-catenin, MAGI-3,EGFR, PtdIns(3,4,5)P3, IGF-1 receptor, Tuberin, ILK, GRB2, 2.7.1.137,AKT(PKB), c-Raf-1, MDM2, Caspase-9

Genes in the TGF-β pathway. p300, MSK1, SOS, NF-kB, TGF-beta receptortype I, SMAD7, p15, Elk-1, TGF-beta 1, SMAD4, Caveolin-1, ErbB2,IKK-beta, TSC-22, TIEG1, FKBP12, SMURF2, APC/hCDH1 complex, FAST-1/2,IKK-alpha, ERK1/2, SMAD3, TAK1(MAP3K7), PAIL ER81, MEKK4(MAP3K4),NFKBIA, GADD45 beta, H-Ras, Anaphase-promoting complex (APC), c-Raf-1,XIAP, TGF-beta receptor type II, SMURF1, CBP, p21, MEK6(MAP2K6), Sno-N,MEK2(MAP2K2), YY1, MEK3(MAP2K3), SARA, SP1, Shc, Importin(karyopherin)-beta, SMAD2, TABT, Ski, p38 MAPK, MEK1(MAP2K1)

FOXO transcription factors: FOXO1, FOXO3a

Genes in the Apoptosis pathways: ACVR1, BCL2L1, BIRC1, CAPN2, CAPNS1,CCNG1, CD47, CD81, CD99, CFLAR, CULT, DAD1, DGKA, DPP4, FST, GZMA,HLA-G, HSPA8, HSPD1, IGF1R, IL15, IL1A, IL2RG, IRS2, ITGB3, MAD2L1,MAP2K1, MAX, NRAS, ODC1, PDGFA, PECAM1, PGRMC1, PRKAR2B, PROS1, PTPN13,RBBP7, RPS3, SERPINB2, SKI, TEGT, TOP1, TPM1, YWHAQ, ZFF148

Genes in the Ubiquitination pathways: CAPN2, CAST, CD47, CFLAR, CLTC,CUL1, ESPL1, FLNA, HSPA8, IRS2, MAD2L1, MAP2K1, SIRT2, SKI, SNRPN, TOP1,UBQLN4, YWHAB, YWHAQ

Genes in the Energy Production pathways: ACVR1, BCL2L1, BIRC1, GSS,HLA-G, HSPA8, HSPD1, IGF1R, IRS2, KATNB1, MAP2K1, PGK1, PMS2, PRKD2,SLC25A3, SNRPN, TCF8, TOP1, TPM1

In certain embodiments, the gene or pathway indicative of oocyte qualityis chosen from a gene expressed in connection with one or more of thefollowing categories (reflecting those listed in Table 1): cell cycle(e.g., mitosis); chromosome segregation or organization (e.g.,chromosome segregation, spindle localization or chromosomeorganization); DNA damage response and repair (e.g., response to DNAdamage stimulus); proteolytic pathway (e.g., proteolysis); energypathway or mitochondrial function (e.g., ATP metabolic process or ATPbinding); cell signaling and communication (e.g., intracellularsignaling cascade or cell-cell signaling); protein transport;transcription regulation; reproductive process (e.g., oogenesis oroviposition); cell death; cell differentiation or cell adhesion.

Other genes have been found to be of interest—among them, genes ofchromatin structure, DNA methylation and genome stability. Inparticular, genes that have been shown to be associated with bothovarian function and general aging have shown promise in the methods,kits and libraries of the present technology. These include SERPINB2(serpin peptidase inhibitor, Glade B, member 2, also known as PAI-2);IGFIR (insulin-like growth factor 1 receptor); PIK3CB(phosphoinositide-3-kinase, catalytic, beta polypeptide), IRS2 (insulinreceptor substrate 2), HSPA8, HSPD1 and HSP60. Two genetic pathways inparticular have been found herein to be significant in the regulation ofreproductive aging. Specifically, it has previously been determined thatTGF-β and insulin/IGF-1 (IIS) signaling pathways regulate reproductiveaging cell non-autonomously. That is, these pathways regulatereproductive aging systemically, outside of the oocyte itself ratherthan by signaling just inside the oocyte. The function of thesesignaling pathways outside of oocytes (that is, in other areas of theorganism's system) can determine the rate of reproductive aging, andanalysis of a systemic tissue such as blood or urine for the activity ofthese pathways can provide useful data, including one or more biologicalindicators of reproductive aging of the oocytes.

In certain embodiments, the present technology is directed totranscriptional analysis of peripheral blood mononuclear cells (PMBCs).RNA sequencing is used to achieve greater sensitivity and depth.Biomarkers of reproductive age and reproductive success have beenidentified. The focus is on the most significant genes associated withreproductive status, regardless of whether the gene function is known ornot, thus removing bias in selection. By using a panel of the genes mostsignificantly associated with reproductive success, and then testing theexpression of these genes for their predictive power, a diagnostic witha high correlation with outcome has been created. Additionally, analysisof the systemic effects on reproduction can inform subsequent approachesfor treatments. Genes that have been shown to be downregulated includemembers of the insulin/IGF-1 (IIS) pathway (IGFAR, IRS2), and increasedSIRT2, a co-regulator of the IIS pathway, is associated with latereproductive success. Therefore, previous studies of the C. elegansreproductive span correlates exactly with these observations in women,that one of the most important regulators of reproductive span appearsto be the IIS pathway. Members of the TGF-β pathway can also be systemicmarkers of reproductive success. IIS can influence both lifespan andreproductive span, while TGF-β has an effect specifically onreproductive span. Thus, IIS differences in PBMCs are thought also toact as a diagnostic for longevity.

Thus, in certain embodiments, the technology herein is directed tomethods for assessing a woman's likely oocyte quality, chances ofconception, comprising developing a quantitative score that offersinformation regarding chances of conception or otherwise a measure oflikelihood of success of an assisted reproductive procedure. In certainembodiments, the score can be calculated as follows: A sample's geneexpression values can be obtained, and then how well the genes match aparticular age can be determined in one of several ways, including butnot limited to the following: (1) by Pearson correlation with a) the setof genes or pathways in the profile, if that is what is available by thegene set qRT-PCR assay, or b) by the Pearson correlation with the entiregene expression profile when the sample's total mRNA-sequence isassessed; or (2) by counting the genes with most extreme FisherZ scoresmore heavily (weighting) that includes the average expression of all thegenes in the set.

The latter could give a single score that depends most heavily on theset of genes already evaluated. The former would likely allow for abetter match of the whole transcriptome by age. In certain embodiments,both scores can be used to assess the score of the sample.

In certain embodiments, a “reproductive age” (as opposed to an actualage) of a given individual can be calculated as follows:

A pre-calculated age-correlation-score Z_(i) for each gene i (for atotal of 19,600 genes in the genome) is based on public gene-expressiondata from blood from females. (These are the “fisherz” scores reportedin all the analyses results.)

Given a new gene-expression sample with normalized expression levelse_(i) for each gene i, the “reproductive-age” a_(rep) of that sampleequals the weighted average of all the genes measured in the sample (N),weighted by the ‘age-correlation’ scores of those genes, in Equation (I)below:

$\begin{matrix}{a_{rep} = \frac{\sum\limits_{t = 1}^{N}\; {z_{i} \cdot e_{i}}}{\sum\limits_{t = 1}^{N}\; z_{i}}} & (I)\end{matrix}$

In certain embodiments, the present technology is directed to a kitcomprising any one or more of the following: (a) a collection containerfor collecting a cell sample; and (b) an assay that measures acharacteristic of a gene or pathway related to oocyte quality. In use, amedical professional, or the patient herself, may collect the cellsample, subject it to the assay and use the results to predict thepatient's oocyte quality. For example, in certain embodiments the kitcan predict a woman's likelihood of conceiving, a woman's “reproductiveage” (as described later herein) or the likelihood that ovulation willresult in a viable oocyte in any given month. Any of these can even bepackaged in conjunction with other tools used by women trying toconceive, including but not limited to ovulation predictor kits, toolsfor measuring body temperature (such as basal body temperaturethermometers), tools for measuring or evaluating mucus signs and otherphysically manifested indicators of fertility and fertile windows.

In various other embodiments, the kit comprises:

(a) a collection container for collecting a cell sample obtained fromthe woman's body;

(b) a testing assay that measures a characteristic of a gene, pathway ortranscriptional profile characteristic of the cell sample, wherein thecharacteristic indicates the likely quality of an oocyte; and

(c) a visual indicator visible to the woman, the visual indicatorproviding information regarding the likely quality of the oocyte.

The visual indicator can be, for example, a color-coded indicatorshowing a binary result such as one color for an above average score,and another for a below average score.

In certain embodiments, the testing assay can be, for example, an RT-PCRassay on blood using the primers for the best genes. In the case ofother samples such as urine or other bodily fluids, an assay can includemetabolomics to assess metabolites or hormones, such as, for example, anenzyme-linked immunosorbent (ELISA) assay. In other embodiments, acolorimetric test could work in the event that the assay is matter ofdetermining the levels of relatively few (e.g., just one, two or three,or in various embodiments fewer than about 10, fewer than about 25 orfewer than about 50) genes, metabolites or hormones. For example, incertain embodiments, the results of the assay could be displayed as oneor more lines that would indicate the score. In certain embodiments,different lines could present different data points or results (forexample, different colors or configurations, with the combinationproviding a score or other type of quantitative or qualitative result).

In certain embodiments, such a kit could be made commercially availablefor at-home use, and could include information taken from a library ofgenes and pathways generated in connection with certain embodimentsherein.

In certain embodiments, the kit will include primers to amplify genes inthis set (genes with FisherZ scores above 2 and below −2; see Table 2)from blood. In certain embodiments, any or all of the sample, or anycharacteristic thereof, can be assigned a score that is equal to theaverage of the expression level of all the genes in the array weightedby the age-correlation (FisherZ) score of each of the genes. This scoreconveys the expected oocyte viability for a woman compared to an averagefor women of the same age.

In certain embodiments, the present technology is directed to a methodfor the production of a library of genes, or a reproductive aging geneexpression profile, as markers of oocyte quality. Such a method maycomprise the steps of correlating a test gene with a quantitative andmeasured characteristic of oocyte quality, listing the correlation inthe library; comparing a measured characteristic of a gene provided by apatient with that listed in the library; and determining the quality ofan oocyte of a patient based on the comparison.

For example, in certain embodiments, a library is produced through anyof the following steps: First, list certain genes known or thought torelate to factors such as ovarian function and general aging. Next,obtain samples of oocytes known to be from women of certain ages (forexample, age 20, age 25, age 30 and the like) and measure one or more ofthe characteristics of those oocytes to obtain baseline values. Next,when a patient desires the assay, a cell sample is taken from thepatient, the one or more characteristics can be determined by runningthe assay on the patient's cell sample and comparing the values to thoseof the library. For example, a patient may be 35 years old but may haveoocytes that are typical of a 25 year old or a 40 year old, asdetermined by a method of the present technology, using the librarygenerated according to this embodiment. This is valuable informationthat the patient can acquire without the need for invasive testing ordestruction of her oocytes, and in certain embodiments, is obtained byimplementing a method or kit in accordance with the embodiments herein.In certain embodiments, a yearly clinical assessment of oocyte age couldallow a clinician or woman to determine the rate of change of oocytequality, yet another indicator that could be useful for diagnostics andfor advising patients.

In certain embodiments, a library can be created and used to establish a“profile set” for a user—that is, a set of one or more genes, pathwaysor transcriptional profiles that indicates various characteristics of auser's oocyte. A candidate gene expression assay can be developed basedon the information obtained from bodily fluids such as blood, thusidentifying biomarkers that correlate with oocyte quality and pregnancysuccess.

In one exemplary method, a library was made by the following steps:

(1) gathering expression data from samples (whole blood and PBMCs) fromwomen in a particular age range (in certain embodiments, aged 20 to 50,but not so limited). An average gene expression for each gene at eachage was calculated by averaging the expression for that gene in a givenrange of time (e.g., a 2 year window, in overlapping (sliding) windows).This allowed the inclusion of about 30 to about 90 samples in each year.In certain embodiments, an average of about 70 to about 80 GEO femaleblood samples were used for each 2 year sliding window; for each gene,the Spearmann correlation of the average gene expression to the agevector was determined, and then sorted by the FisherZ score; a scoreabove 2 (top 5%) was used to generate a set of significantly changedage-dependent genes, all candidate biomarkers.

(2) The gene expression data were compared to an “age vector” toindicate which genes changed most with age. Since most genes do not havean age-related change in expression, the data are normally distributed.The FisherZ score makes it possible to find the genes at the tail endsof the distribution; those genes are most changed with age, and thus arethe best indicators of biological age. Such genes are included in thelibrary, and can be used to compare with data acquired from the testsubject.

For the samples of women aged 25 to 50, in certain embodiments onlysamples from women who have no known fertility defect (i.e., presence atIVF clinic is due to sperm or other partner issue) can be used toestablish a “young” profile. The expression profiles can then be sortedaccording to age and further segregated by pregnancy success/failure andother cytological information, and PCA can be performed to identify thegenes best correlated with pregnancy success. Using qRT-PCR, the topgenes most associated with pregnancy outcome can be tested on a separatesample set prior to IVF (or other ART treatment) to verify predictivepower of the gene set. The most predictive genes can be used to developa diagnostic tool that can be used in clinics after a simple blood drawor urine collection. The clinical procedure RT-PCR can be performed onRNA from blood samples using the mix of primers of the best candidategenes.

FIG. 2 shows a heat map of the results showing gene trees. Tables 2 and3 below shows data from FIG. 2 in numerical form. Table 2 shows theresults for ages 20-33; Table 3 shows the results for ages 34-40.

TABLE 2 gene symbol name fisherz 20 21 56904 SH3GLB2 SH3-domain 3.67−0.38 −0.45 GRB2-like endophilin B2 6464 SHC1 SHC (Src 3.56 −0.45 −1.44homology 2 domain containing) transforming protein 1 79087 ALG12 ALG12,alpha- 3.45 −0.66 −0.84 1,6- mannosyltransferase 101928190 LOC101928190uncharacterized 3.43 −1.81 −1.56 LOC101928190 3416 IDE insulin- 3.17−0.90 −0.60 degrading enzyme 8001 GLRA3 glycine receptor, 3.16 −0.68−1.27 alpha 3 3727 JUND jun D proto- 3.13 −0.39 −1.05 oncogene 10945KDELR1 KDEL (Lys- 3.12 −0.05 −1.56 Asp-Glu-Leu) endoplasmic reticulumprotein retention receptor 1 5025 P2RX4 purinergic 3.09 −0.52 −0.03receptor P2X, ligand-gated ion channel, 4 29920 PYCR2 pyrroline-5- 3.07−0.44 −0.06 carboxylate reductase family, member 2 101929248LOC101929248 uncharacterized 3.01 −0.18 −0.66 LOC101929248 23646 PLD3phospholipase D 2.98 −0.35 −1.18 family, member 3 10280 SIGMAR1 sigmanon- 2.97 −0.26 −0.98 opioid intracellular receptor 1 140699 MROH8maestro heat- 2.96 −1.96 −1.29 like repeat family member 8 4669 NAGLU N-2.94 1.04 −1.05 acetylglucosaminidase, alpha 8341 HIST1H2BN histonecluster 2.91 −0.20 −1.26 1, H2bn 2519 FUCA2 fucosidase, 2.90 −2.72 −1.16alpha-L-2, plasma 8985 PLOD3 procollagen- 2.88 0.48 −0.96 lysine, 2-oxoglutarate 5- dioxygenase 3 1690 COCH cochlin 2.87 −0.79 −2.11 5111ZDHHC9 zinc finger, 2.86 0.19 −0.88 DHHC-type containing 9 55907 CMAScytidine 2.85 −0.20 −0.12 monophosphate N- acetylneuraminic acidsynthetase 144811 LACC1 laccase 2.84 0.65 −2.69 (multicopperoxidoreductase) domain containing 1 92421 CHMP4C charged 2.84 −1.75 0.40multivesicular body protein 4C 23475 QPRT quinolinate 2.83 0.03 −0.54phosphoribosyltransferase 54913 RPP25 ribonuclease 2.77 −1.16 −1.29P/MRP 25 kDa subunit 4645 MYO5B myosin VB 2.76 −1.61 −0.94 9917 FAM20Bfamily with 2.74 −0.21 −0.82 sequence similarity 20, member B 57213SPRYD7 SPRY domain 2.73 0.00 −1.85 containing 7 113829 SLC35A4 solutecarrier 2.73 −0.37 −0.56 family 35, member A4 100128164 LOC100128164four and a half 2.72 −1.16 −0.96 LIM domains 1 pseudogene 26284 ERAL1Era-like 1 2S 2.70 0.75 −0.67 mitochondrial rRNA chaperone 1 64847SPATA20 spermatogenesis 2.70 1.79 −1.47 associated 20 55974 SLC50A1solute carrier 2.69 −0.45 −0.88 family 50 (sugar efflux transporter),member 1 64405 CDH22 cadherin 22, 2.68 −0.95 −1.41 type 2 6510 SLC1A5solute carrier 2.68 −0.54 −1.66 family 1 (neutral amino acidtransporter), member 5 196463 PLBD2 phospholipase B 2.67 −0.48 −1.13domain containing 2 741 ZNHIT2 zinc finger, 2.67 −2.15 0.74 HIT-typecontaining 2 23568 ARL2BP ADP- 2.66 0.53 0.31 ribosylation factor-like 2binding protein 79144 PPDPF pancreatic 2.66 0.02 −1.75 progenitor celldifferentiation and proliferation factor 91319 DERL3 derlin 3 2.66 −0.64−0.55 79654 HECTD3 HECT domain 2.64 0.28 −2.10 containing E3 ubiquitinprotein ligase 3 115950 ZNF653 zinc finger 2.63 −0.11 −0.32 protein 6531374 CPT1A carnitine 2.63 −0.46 −1.45 palmitoyltransferase 1A (liver)81533 ITFG1 integrin alpha 2.62 −2.21 −1.14 FG-GAP repeat containing 1201931 TMEM192 transmembrane 2.60 −1.17 −1.00 protein 192 7979 SHFM1split hand/foot 2.60 −0.03 0.14 malformation (ectrodactyly) type 1159296 NKX2-3 NK2 homeobox 3 2.59 0.18 −0.81 51102 MECR mitochondrial2.59 0.73 −0.13 trans-2-enoyl- CoA reductase 8729 GBF1 golgi brefeldin2.59 −0.82 −0.51 A resistant guanine nucleotide exchange factor 1 118460EXOSC6 exosome 2.58 −0.87 0.01 component 6 79586 CHPF chondroitin 2.57−1.64 −0.31 polymerizing factor 2052 EPHX1 epoxide 2.54 0.15 −2.10hydrolase 1, microsomal (xenobiotic) 84893 FBXO18 F-box protein, 2.53−1.99 0.08 helicase, 18 54726 OTUD4 OTU domain 2.53 −0.35 0.31containing 4 813 CALU calumenin 2.53 −0.42 0.21 54431 DNAJC10 DnaJ(Hsp40) 2.52 0.67 −1.18 homolog, subfamily C, member 10 9612 NCOR2nuclear receptor 2.52 −0.79 −1.22 corepressor 2 9829 DNAJC6 DnaJ (Hsp40)2.51 −1.56 0.25 homolog, subfamily C, member 6 79036 KXD1 KxDL motif2.51 −1.30 −0.97 containing 1 284361 EMC10 ER membrane 2.51 0.21 −0.27protein complex subunit 10 131118 DNAJC19 DnaJ (Hsp40) 2.50 −0.13 −0.23homolog, subfamily C, member 19 644809 C15orf56 chromosome 15 2.50 −2.50−1.68 open reading frame 56 2119 ETV5 ets variant 5 2.50 0.74 −2.06 5833PCYT2 phosphate 2.50 −0.95 −0.34 cytidylyltransferase 2, ethanolamine922 CD5L CD5 molecule- 2.49 0.26 −1.47 like 9261 MAPKAPK2 mitogen- 2.49−0.65 −0.96 activated protein kinase-activated protein kinase 2 57190SEPN1 selenoprotein N, 1 2.49 −0.88 −0.59 79644 SRD5A3 steroid 5 alpha-2.48 1.23 −0.67 reductase 3 79058 ASPSCR1 alveolar soft part 2.48 −0.540.00 sarcoma chromosome region, candidate 1 7832 BTG2 BTG family, 2.47−0.51 −0.67 member 2 11070 TMEM115 transmembrane 2.47 0.00 −0.03 protein115 10847 SRCAP Snf2-related 2.46 −1.45 −0.63 CREBBP activator protein4597 MVD mevalonate 2.46 −1.41 −1.21 (diphospho) decarboxylase 100506696PCAT6 prostate cancer 2.45 0.45 −0.79 associated transcript 6(non-protein coding) 100507459 LOC100507459 uncharacterized 2.45 −0.67−2.06 LOC100507459 100130613 CXorf64 chromosome X 2.45 −0.70 −0.39 openreading frame 64 5081 PAX7 paired box 7 2.45 −0.18 −0.61 100240728LOC100240728 uncharacterized 2.44 0.45 −0.36 LOC100240728 26229 B3GAT3beta-1,3- 2.44 −0.09 0.75 glucuronyltransferase 3(glucuronosyltransferase I) 950 SCARB2 scavenger 2.44 0.11 −1.84receptor class B, member 2 161882 ZFPM1 zinc finger 2.44 0.78 −1.19protein, FOG family member 1 5034 P4HB prolyl 4- 2.43 −0.03 −0.65hydroxylase, beta polypeptide 123355 LRRC28 leucine rich 2.43 −3.02−0.37 repeat containing 28 6734 SRPR signal 2.43 −0.95 −0.99 recognitionparticle receptor (docking protein) 9911 TMCC2 transmembrane 2.43 −0.31−1.12 and coiled-coil domain family 2 222642 TSPO2 translocator 2.42−0.04 −0.31 protein 2 3643 INSR insulin receptor 2.42 −1.47 −1.69 85462FHDC1 FH2 domain 2.41 −1.86 −1.61 containing 1 149175 MANEALmannosidase, 2.40 0.96 −1.03 endo-alpha-like 1819 DRG2 developmentally2.40 −0.30 0.61 regulated GTP binding protein 2 10370 CITED2 Cbp/p300-2.39 −0.55 −1.11 interacting transactivator, with Glu/Asp- rich carboxy-terminal domain, 2 25792 CIZ1 CDKN1A 2.39 −0.51 −0.14 interacting zincfinger protein 1 4072 EPCAM epithelial cell 2.39 −0.61 −0.92 adhesionmolecule 84447 SYVN1 synovial 2.39 −0.16 −1.58 apoptosis inhibitor 1,synoviolin 527 ATP6V0C ATPase, H+ 2.39 −1.34 −1.27 transporting,lysosomal 16 kDa, V0 subunit c 10629 TAF6L TAF6-like RNA 2.38 −0.68−0.53 polymerase II, p300/CBP- associated factor (PCAF)- associatedfactor, 65 kDa 51150 SDF4 stromal cell 2.38 −0.19 −0.15 derived factor 457143 ADCK1 aarF domain 2.37 −0.37 −0.83 containing kinase 1 682 BSGbasigin 2.37 −0.21 −1.33 10139 ARFRP1 ADP- 2.37 −1.43 0.38 ribosylationfactor related protein 1 203238 CCDC171 coiled-coil 2.37 0.06 −0.78domain containing 171 54805 CNNM2 cyclin M2 2.37 −0.64 0.23 1200 TPP1tripeptidyl 2.37 0.19 −2.22 peptidase I 2271 FH fumarate 2.37 −0.93−0.36 hydratase 376412 RNF126P1 ring finger 2.37 −0.06 −0.52 protein 126pseudogene 1 4924 NUCB1 nucleobindin 1 2.37 −1.22 −1.33 55132 LARP1B La2.37 0.00 0.03 ribonucleoprotein domain family, member 1B 9650 MTFR1mitochondrial 2.37 0.28 −0.07 fission regulator 1 29803 REPIN1replication 2.36 −0.05 −2.01 initiator 1 4507 MTAP methylthioadenosine2.36 −0.50 0.16 phosphorylase 816 CAMK2B calcium/calmodulin- 2.36 −0.96−1.38 dependent protein kinase II beta 120379 PIH1D2 PIH1 domain 2.360.24 −0.66 containing 2 91289 LMF2 lipase 2.36 −0.15 −1.01 maturationfactor 2 10905 MAN1A2 mannosidase, 2.35 −0.52 −0.40 alpha, class 1A,member 2 25930 PTPN23 protein tyrosine 2.35 −0.79 −1.96 phosphatase,non-receptor type 23 57648 KIAA1522 KIAA1522 2.35 −1.31 −1.46 7249 TSC2tuberous 2.35 −0.03 −0.57 sclerosis 2 55151 TMEM38B transmembrane 2.340.29 −0.25 protein 38B 160728 SLC5A8 solute carrier 2.33 −1.06 −1.61family 5 (sodium/monocarboxylate cotransporter), member 8 148418 SAMD13sterile alpha 2.33 −0.78 0.86 motif domain containing 13 646762LOC646762 uncharacterized 2.32 −0.60 −1.03 LOC646762 79109 MAPKAP1mitogen- 2.32 −0.93 −0.74 activated protein kinase associated protein 181037 CLPTM1L CLPTM1-like 2.31 −0.28 −0.13 51523 CXXC5 CXXC finger 2.290.91 −1.19 protein 5 55322 C5orf22 chromosome 5 2.29 −0.14 −1.05 openreading frame 22 100996671 LOC100996671 uncharacterized 2.29 −1.07 0.25LOC100996671 55222 LRRC20 leucine rich 2.29 0.14 0.15 repeat containing20 55624 POMGNT1 protein O-linked 2.29 0.42 −0.59 mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 100505983 LOC100505983uncharacterized 2.28 −0.30 −1.40 LOC100505983 3069 HDLBP high density2.28 0.02 −0.50 lipoprotein binding protein 10959 TMED2 transmembrane2.28 −0.64 0.50 emp24 domain trafficking protein 2 6598 SMARCB1 SWI/SNF2.28 −0.03 −1.04 related, matrix associated, actin dependent regulatorof chromatin, subfamily b, member 1 60412 EXOC4 exocyst complex 2.27−0.97 −0.75 component 4 54982 CLN6 ceroid- 2.27 −0.22 −0.05lipofuscinosis, neuronal 6, late infantile, variant 91752 ZNF804A zincfinger 2.27 −0.60 −0.96 protein 804A 113178 SCAMP4 secretory carrier2.26 −0.63 −0.57 membrane protein 4 10 NAT2 N- 2.26 −2.14 −0.97acetyltransferase 2 (arylamine N- acetyltransferase) 375 ARF1 ADP- 2.26−0.93 0.03 ribosylation factor 1 5589 PRKCSH protein kinase C 2.26 −0.64−1.59 substrate 80K-H 9136 RRP9 ribosomal RNA 2.26 −0.92 0.08 processing9, small subunit (SSU) processome component, homolog (yeast) 23193 GANABglucosidase, 2.26 −0.20 0.04 alpha; neutral AB 1798 DPAGT1 dolichyl-2.25 0.46 −0.97 phosphate (UDP-N- acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 85440DOCK7 dedicator of 2.25 0.62 −1.10 cytokinesis 7 100505794 LOC100505794uncharacterized 2.24 −1.88 −0.15 LOC100505794 1173 AP2M1 adaptor-related2.24 0.00 −0.87 protein complex 2, mu 1 subunit 124540 MSI2 musashi RNA-2.24 −0.83 −0.24 binding protein 2 8372 HYAL3 hyaluronoglucosaminidase 32.24 −0.32 0.20 64755 C16orf58 chromosome 16 2.24 0.94 −0.41 openreading frame 58 79102 RNF26 ring finger 2.24 −0.02 −0.85 protein 2610963 STIP1 stress-induced- 2.24 −1.07 −0.30 phosphoprotein 1 375387NRROS negative 2.24 0.14 −0.08 regulator of reactive oxygen species 972CD74 CD74 molecule, 2.23 1.04 −3.36 major histocompatibility complex,class II invariant chain 54676 GTPBP2 GTP binding 2.23 0.44 −1.39protein 2 192286 HIGD2A HIG1 hypoxia 2.23 1.25 −0.69 inducible domainfamily, member 2A 3295 HSD17B4 hydroxysteroid 2.23 −0.22 −1.28 (17-beta)dehydrogenase 4 80852 GRIP2 glutamate 2.23 −1.32 −0.75 receptorinteracting protein 2 1298 COL9A2 collagen, type 2.22 −1.39 −2.02 IX,alpha 2 2004 ELK3 ELK3, ETS- 2.22 0.12 −0.69 domain protein (SRFaccessory protein 2) 10279 PRSS1 protease, serine, 2.22 0.08 0.44 16(thymus) 151790 WDR49 WD repeat 2.22 −1.01 −1.82 domain 49 399664 MEX3Dmex-3 RNA 2.21 −1.01 0.55 binding family member D 5664 PSEN2 presenilin2 2.21 1.22 −1.57 (Alzheimer disease 4) 51614 ERGIC3 ERGIC and 2.21 0.53−0.17 golgi 3 79178 THTPA thiamine 2.21 0.37 −0.69 triphosphatase 51726DNAJB11 DnaJ (Hsp40) 2.20 −0.15 0.16 homolog, subfamily B, member 113425 IDUA iduronidase, 2.20 0.16 0.01 alpha-L- 1642 DDB1 damage-specific2.20 0.72 −0.92 DNA binding protein 1, 127 kDa 101928770 LOC101928770uncharacterized 2.19 −1.77 −0.87 LOC101928770 11015 KDELR3 KDEL (Lys-2.19 0.74 −1.45 Asp-Glu-Leu) endoplasmic reticulum protein retentionreceptor 3 35 ACADS acyl-CoA 2.19 −0.36 −0.45 dehydrogenase, C-2 to C-3short chain 64798 DEPTOR DEP domain 2.19 0.99 −0.91 containing MTOR-interacting protein 23457 ABCB9 ATP-binding 2.19 −0.90 −0.60 cassette,sub- family B (MDR/TAP), member 9 56132 PCDHB3 protocadherin 2.19 −1.400.21 beta 3 23400 ATP13A2 ATPase type 2.19 0.69 0.78 13A2 3980 LIG3ligase III, DNA, 2.19 −1.66 0.65 ATP-dependent 5690 PSMB2 proteasome2.19 −0.48 −1.31 (prosome, macropain) subunit, beta type, 2 7917 BAG6BCL2- 2.19 0.61 −1.07 associated athanogene 6 1739 DLG1 discs, large2.18 −0.19 0.09 homolog 1 (Drosophila) 2837 UTS2R urotensin 2 2.18 0.03−1.24 receptor 83746 L3MBTL2 l(3)mbt-like 2 2.18 −0.32 0.57 (Drosophila)5962 RDX radixin 2.18 1.15 −0.45 9956 HS3ST2 heparan sulfate 2.18 0.52−0.59 (glucosamine) 3-O- sulfotransferase 2 162968 ZNF497 zinc finger2.18 −0.39 −0.58 protein 497 4192 MDK midkine (neurite 2.18 0.14 −1.17growth- promoting factor 2) 54919 HEATR2 HEAT repeat 2.18 −0.66 −0.12containing 2 10972 TMED10 transmembrane 2.17 0.29 −0.15 emp24-liketrafficking protein 10 (yeast) 23061 TBC1D9B TBC1 domain 2.17 0.25 −1.61family, member 9B (with GRAM domain) 3792 KEL Kell blood 2.17 −1.53−0.95 group, metallo- endopeptidase 2063 NR2F6 nuclear receptor 2.170.08 −1.78 subfamily 2, group F, member 6 55177 RMDN3 regulator of 2.17−0.02 −0.72 microtubule dynamics 3 11147 HHLA3 HERV-H LTR- 2.17 −0.01−0.94 associating 3 57486 NLN neurolysin 2.17 −0.76 −2.12(metallopeptidase M3 family) 30814 PLA2G2E phospholipase 2.16 −1.73−0.14 A2, group IIE 57414 RHBDD2 rhomboid 2.16 −0.83 0.47 domain 2containing 2 84836 ABHD14B abhydrolase 2.16 0.25 −0.70 domain containing14B 8516 ITGA8 integrin, alpha 8 2.16 −1.05 −0.45 89866 SEC16B SEC16homolog 2.16 0.34 −1.11 B (S. cerevisiae) 10491 CRTAP cartilage 2.16−0.42 −1.22 associated protein 11047 ADRM1 adhesion 2.16 −0.86 −0.75regulating molecule 1 28971 AAMDC adipogenesis 2.16 −0.57 −1.44associated, Mth938 domain containing 8078 USP5 ubiquitin 2.16 −0.20−1.15 specific peptidase 5 (isopeptidase T) 37 ACADVL acyl-CoA 2.16 0.77−1.27 dehydrogenase, very long chain 145508 CEP128 centrosomal 2.15−1.44 −0.13 protein 128 kDa 49861 CLDN20 claudin 20 2.15 −1.53 −0.995905 RANGAP1 Ran GTPase 2.15 0.36 0.13 activating protein 1 7542 ZFPL1zinc finger 2.15 −0.61 −0.83 protein-like 1 9562 MINPP1 multiple 2.150.75 −0.88 inositol- polyphosphate phosphatase 1 79095 C9orf16chromosome 9 2.15 −0.91 −1.40 open reading frame 16 8815 BANF1 barrierto 2.15 −0.86 −0.94 autointegration factor 1 54867 TMEM214 transmembrane2.15 −0.36 −1.15 protein 214 6721 SREBF2 sterol regulatory 2.15 −0.66−1.09 element binding transcription factor 2 23133 PHF8 PHD finger 2.15−2.33 −0.20 protein 8 113675 SDSL serine 2.14 −0.45 −1.26dehydratase-like 129303 TMEM150A transmembrane 2.14 −1.19 −0.27 protein150A 57658 CALCOCO1 calcium binding 2.14 −0.87 −2.39 and coiled-coildomain 1 162 AP1B1 adaptor-related 2.14 0.16 −2.22 protein complex 1,beta 1 subunit 2873 GPS1 G protein 2.14 −0.39 0.88 pathway suppressor 164978 MRPL38 mitochondrial 2.14 −1.05 0.55 ribosomal protein L38 220323OAF OAF homolog 2.14 1.31 −1.11 (Drosophila) 6006 RHCE Rh blood group,2.14 −0.69 −0.91 CcEe antigens 389812 LCN15 lipocalin 15 2.14 0.12 −1.102628 GATM glycine 2.13 −0.78 −2.26 amidinotransferase (L-arginine:glycine amidinotransferase) 6509 SLC1A4 solute carrier 2.13−1.52 0.41 family 1 (glutamate/neutral amino acid transporter), member 43888 KRT82 keratin 82 2.13 −0.47 −0.10 5211 PFKL phosphofructokinase,2.13 0.14 −1.68 liver 55080 TAPBPL TAP binding 2.13 −0.22 −1.22protein-like 2139 EYA2 eyes absent 2.13 −1.64 0.08 homolog 2(Drosophila) 2030 SLC29A1 solute carrier 2.12 0.75 −0.96 family 29(equilibrative nucleoside transporter), member 1 56005 C19orf10chromosome 19 2.12 −0.77 −0.18 open reading frame 10 6414 SEPP1selenoprotein P, 2.12 1.63 −1.72 plasma, 1 5184 PEPD peptidase D 2.12−0.14 −1.08 643783 USP46- USP46 antisense 2.12 0.35 −1.04 AS1 RNA 1101928185 LOC101928185 uncharacterized 2.12 −1.31 −1.64 LOC10192818522883 CLSTN1 calsyntenin 1 2.12 −0.33 −1.22 25800 SLC39A6 solute carrier2.12 0.89 −1.29 family 39 (zinc 6 transporter), member 6 54681 P4HTMprolyl 4- 2.12 1.14 −1.11 hydroxylase, transmembrane (endoplasmicreticulum) 644150 WIPF3 WAS/WASL 2.12 −1.29 0.15 interacting proteinfamily, member 3 9048 ARTN artemin 2.12 0.12 −1.89 3054 HCFC1 host cellfactor 2.11 0.43 −0.62 C1 (VP16- accessory protein) 115098 CCDC124coiled-coil 2.11 −1.85 0.10 domain containing 124 55558 PLXNA3 plexin A32.11 0.92 −0.78 675 BRCA2 breast cancer 2, 2.11 0.63 −0.16 early onset9777 TM9SF4 transmembrane 2.11 1.49 −1.09 9 superfamily protein member 483707 TRPT1 tRNA 2.11 −0.04 −0.15 phosphotransferase 1 55334 SLC39A9solute carrier 2.10 −1.47 −2.10 family 39, member 9 9793 CKAP5cytoskeleton 2.10 0.88 −0.71 associated protein 5 56834 GPR137 Gprotein- 2.10 0.20 −1.10 coupled receptor 137 25921 ZDHHC5 zinc finger,2.10 0.57 −1.11 DHHC-type containing 5 6520 SLC3A2 solute carrier 2.10−0.83 0.35 family 3 (amino acid transparter heavy chain), member 2728591 CCDC169 coiled-coil 2.10 0.35 −1.49 domain containing 169 7415VCP valosin 2.10 −0.60 −0.61 containing protein 130827 TMEM182transmembrane 2.09 0.93 −1.07 protein 182 9620 CELSR1 cadherin, EGF 2.09−0.77 −0.90 LAG seven-pass G-type receptor 1 55335 NIPSNAP3B nipsnap2.09 0.69 0.11 homolog 3B (C. elegans) 84988 PPP1R16A protein 2.08 −0.45−0.84 phosphatase 1, regulatory subunit 16A 100192378 ZFHX4- ZFHX4 2.08−2.06 −0.64 AS1 antisense RNA1 442524 DPY19L2P3 DPY19L2 2.08 −1.30 −0.58pseudogene 3 51661 FKBP7 FK506 binding 2.08 −0.88 −0.66 protein 7 84922FIZ1 FLT3- 2.08 −0.46 0.44 interacting zinc finger 1 84954 MPND MPNdomain 2.08 −0.90 −1.51 containing 245972 ATP6V0D2 ATPase, H+ 2.08 −1.56−0.90 transporting, lysosomal 38 kDa, V0 subunit d2 4316 MMP7 matrix2.08 0.13 −0.58 metallopeptidase 7 (matrilysin, uterine) 55157 DARS2aspartyl-tRNA 2.08 −0.09 −0.44 synthetase 2, mitochondrial 7466 WFS1Wolfram 2.08 −0.39 −1.04 syndrome 1 (wolframin) 79365 BHLHE41 basichelix-loop- 2.08 −0.44 −0.14 helix family, member e41 10066 SCAMP2secretory carrier 2.08 0.95 −0.99 membrane protein 2 203068 TUBBtubulin, beta 2.08 0.35 −0.93 class I 5780 PTPN9 protein tyrosine 2.07−0.81 −1.50 phosphatase, non-receptor type 9 285627 LOC285627uncharacterized 2.07 −0.60 −1.20 LOC285627 2058 EPRS glutamyl-prolyl-2.07 1.25 −0.56 tRNA synthetase 1737 DLAT dihydrolipoamide 2.06 0.55−0.03 S- acetyltransferase 22924 MAPRE3 microtubule- 2.06 −1.75 −1.32associated protein, RP/EB family, member 3 6005 RHAG Rh-associated 2.060.29 −0.86 glycoprotein 5286 PIK3C2A phosphatidylinositol- 2.06 0.32−0.71 4- phosphate 3- kinase, catalytic subunit type 2 alpha 11226GALNT6 UDP-N-acetyl- 2.06 −0.01 −0.06 alpha-D- galactosamine:polypeptideN- acetylgalactosaminyltransferase 6 (GalNAc-T6) 2762 GMDS GDP-mannose2.06 −0.47 −0.69 4,6-dehydratase 8908 GYG2 glycogenin 2 2.06 −1.16 −0.5410693 CCT6B chaperonin 2.06 −0.80 0.01 containing TCP1, subunit 6B (zeta2) 199953 TMEM201 transmembrane 2.06 0.96 −0.49 protein 201 2760 GM2AGM2 2.06 −0.83 −2.47 ganglioside activator 8295 TRRAPtransformation/transcription 2.06 −0.95 0.47 domain- associated protein1822 ATN1 atrophin 1 2.06 0.34 −1.85 55328 RNLS renalase, FAD- 2.06−1.82 −1.29 dependent amine oxidase 2069 EREG epiregulin 2.05 0.33 −1.084329 ALDH6A1 aldehyde 2.05 −0.73 −1.24 dehydrogenase 6 family, member A1537 ATP6AP1 ATPase, H+ 2.05 −0.44 −0.63 transporting, lysosomalaccessory protein 1 64764 CREB3L2 cAMP 2.05 0.14 −0.79 responsiveelement binding protein 3-like 2 811 CALR calreticulin 2.05 −0.14 −0.899779 TBC1D5 TBC1 domain 2.05 −1.68 −2.31 family, member 5 114815 SORCS1sortilin-related 2.05 0.76 −1.44 VPS10 domain containing receptor 129927 SEC61A1 Sec61 alpha 1 2.05 0.85 −0.38 subunit (S. cerevisiae) 6007RHD Rh blood group, 2.05 −0.65 −0.49 D antigen 5192 PEX10 peroxisomal2.05 0.46 −0.02 biogenesis factor 10 125875 CLDND2 claudin domain 2.04−0.14 −0.57 containing 2 10882 C1QL1 complement 2.04 −1.07 −0.41component 1, q subcomponent- like 1 192683 SCAMP5 secretory carrier 2.04−1.38 −0.77 membrane protein 5 8028 MLLT10 myeloid/lymphoid 2.04 −0.77−0.35 or mixed- lineage leukemia (trithorax homolog, Drosophila);translocated to, 10 150368 FAM109B family with 2.04 −2.05 −0.51 sequencesimilarity 109, member B 84206 MEX3B mex-3 RNA 2.04 0.32 −0.13 bindingfamily member B 101929288 LOC101929288 uncharacterized 2.04 1.28 −1.48LOC101929288 826 CAPNS1 calpain, small 2.04 0.59 −1.22 subunit 1 83440ADPGK ADP-dependent 2.04 −0.02 −0.60 glucokinase 1128 CHRM1 cholinergic2.03 −1.51 −0.76 receptor, muscarinic 1 160287 LDHAL6A lactate 2.03−2.65 −1.74 dehydrogenase A-like 6A 412 STS steroid sulfatase 2.03 −1.76−1.65 (microsomal), isozyme S 64215 DNAJC1 DnaJ (Hsp40) 2.03 1.51 −1.51homolog, subfamily C, member 1 7343 UBTF upstream 2.03 −0.53 −0.11binding transcription factor, RNA polymerase I 25840 METTL7Amethyltransferase 2.03 −0.61 −2.47 like 7A 55315 SLC29A3 solute carrier2.03 −0.28 −1.38 family 29 (equilibrative nucleoside transporter),member 3 100507513 LOC100507513 uncharacterized 2.03 −2.70 −0.19LOC100507513 55704 CCDC88A coiled-coil 2.03 0.69 −1.77 domain containing88A 57604 KIAA1456 KIAA1 456 2.03 −0.70 −0.30 10449 ACAA2 acetyl-CoA2.03 −1.02 0.19 acyltransferase 2 1727 CYB5R3 cytochrome b5 2.03 −0.54−2.22 reductase 3 9569 GTF2IRD1 GTF2I repeat 2.03 0.34 −1.07 domaincontaining 1 10009 ZBTB33 zinc finger and 2.02 0.14 −0.17 BTB domaincontaining 33 5188 PET112 PET112 2.02 0.13 0.24 homolog (yeast) 2132EXT2 exostosin 2.02 −0.14 −0.75 glycosyltransferase 2 2239 GPC4 glypican4 2.02 −0.72 −2.04 56927 GPR108 G protein- 2.02 −1.22 −0.51 coupledreceptor 108 2950 GSTP1 glutathione S- 2.02 0.65 −1.37 transferase pi 1342538 NACA2 nascent 2.02 −0.31 −0.61 polypeptide- associated complexalpha subunit 2 55218 EXD2 exonuclease 3′- 2.02 −0.54 −0.04 5′ domaincontaining 2 151827 LRRC34 leucine rich 2.01 0.17 −1.19 repeatcontaining 34 64689 GORASP1 golgi 2.01 0.31 −0.64 reassembly stackingprotein 1, 65 kDa 10324 KLHL41 ketch-like 2.01 −1.94 −0.23 family member41 1314 COPA coatomer 2.01 0.86 −0.79 protein complex, subunit alpha54928 IMPAD1 inositol 2.01 −0.51 −0.54 monophosphatase domain containing1 8971 Hl FX Hl histone 2.01 0.81 −0.77 family, member X 79832 QSER1glutamine and 2.01 0.76 −2.38 serine rich 1 10150 MBNL2 muscleblind-like2.00 0.94 −0.70 splicing regulator 2 8744 TNFSF9 tumor necrosis 2.00−0.11 −0.84 factor (ligand) superfamily, member 9 23287 AGTPBP1 ATP/GTP−2.00 −1.57 0.97 binding protein 1 606553 C8orf49 chromosome 8 −2.002.76 0.90 open reading frame 49 103 ADAR adenosine −2.01 −0.46 0.24deaminase, RNA-specific 55509 BATF3 basic leucine −2.01 2.57 −0.14zipper transcription factor, ATF-like 3 729614 FLJ37453 uncharacterized−2.01 −0.39 1.58 LOC729614 9241 NOG noggin −2.01 0.41 2.02 26118 WSB1 WDrepeat and −2.01 1.08 0.29 SOCS box containing 1 64400 AKTIP AKTinteracting −2.01 −0.63 1.59 protein 283237 TTC9C tetratricopeptide−2.01 2.06 1.25 repeat domain 9C 51155 HN1 hematological −2.01 −0.850.39 and neurological expressed 1 18 ABAT 4-aminobutyrate −2.01 −1.100.52 aminotransferase 22990 PCNX pecanex −2.01 −1.17 0.95 homolog(Drosophila) 23347 SMCHD1 structural −2.01 −1.02 0.76 maintenance ofchromosomes flexible hinge domain containing 1 83988 NCALD neurocalcin−2.01 1.58 0.85 delta 3428 IFI16 interferon, −2.02 −0.62 0.35 gamma-inducible protein 16 3700 ITIH4 inter-alpha- −2.02 −2.31 1.74 trypsininhibitor heavy chain family, member 4 64859 NABP1 nucleic acid −2.020.63 −0.50 binding protein 1 55192 DNAJC17 DnaJ (Hsp40) −2.02 0.76 2.14homolog, subfamily C, member 17 101928869 LOC101928869 uncharacterized−2.02 −0.94 0.98 LOC101928869 10513 APPBP2 amyloid beta −2.02 0.18 1.66precursor protein (cytoplasmic tail) binding protein 2 11009 IL24interleukin 24 −2.02 1.97 0.89 169355 IDO2 indoleamine 2,3- −2.02 1.520.85 dioxygenase 2 10109 ARPC2 actin related −2.02 0.24 0.98 protein 2/3complex, subunit 2, 34 kDa 9903 KLHL21 kelch-like −2.02 −1.20 1.23family member 21 23150 FRMD4B FERM domain −2.03 1.12 0.47 containing 4B10865 ARID5A AT rich −2.03 0.52 1.51 interactive domain 5A (MRF1-like)5165 PDK3 pyruvate −2.03 −0.54 0.91 dehydrogenase kinase, isozyme 357403 RAB22A RAB22A, −2.03 −0.08 2.12 member RAS oncogene family 22900CARD8 caspase −2.03 0.52 0.73 recruitment domain family, member 8 80345ZSCAN16 zinc finger and −2.03 0.80 0.98 SCAN domain containing 16 10964IFI44L interferon- −2.03 −0.11 1.45 induced protein 44-like 27040 LATlinker for −2.03 0.98 2.49 activation of T cells 91010 FMNL3 formin-like3 −2.03 1.02 1.86 29065 ASAP1- ASAP1 intronic −2.04 −0.30 −0.18 IT1transcript 1 (non-protein coding) 84078 KBTBD7 kelch repeat and −2.04−1.19 0.90 BTB (POZ) domain containing 7 101927910 LOC101927910 keratin-−2.04 −0.31 2.24 associated protein 5-5-like 51380 CSAD cysteinesulfinic −2.04 −0.09 −0.06 acid decarboxylase 10289 EIF1B eukaryotic−2.04 −0.24 0.83 translation initiation factor 1B 10296 MAEA macrophage−2.04 −0.68 0.90 erythroblast attacher 114224 PRO2852 uncharacterized−2.04 0.11 −0.51 protein PRO2852 2153 F5 coagulation −2.04 −1.17 0.70factor V (proaccelerin, labile factor) 55825 PECR peroxisomal −2.04−0.87 0.84 trans-2-enoyl- CoA reductase 6503 SLA Src-like-adaptor −2.04−0.29 1.61 7913 DEK DEK oncogene −2.04 1.72 0.60 30834 ZNRD1 zinc ribbon−2.04 −0.10 2.21 domain containing 1 26999 CYFIP2 cytoplasmic −2.05−1.41 2.03 FMR1 interacting protein 2 286437 LOC286437 uncharacterized−2.05 −1.23 1.77 LOC286437 4277 MICB MHC class I −2.05 0.44 0.88polypeptide- related sequence B 5698 PSMB9 proteasome −2.05 0.22 0.77(prosome, macropain) subunit, beta type, 9 4318 MMP9 matrix −2.05 0.130.27 metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IVcollagenase) 10616 RBCK1 RanBP-type and −2.06 1.31 −0.02 C3HC4-type zincfinger containing 1 23012 STK38L serine/threonine −2.06 −0.51 0.07kinase 38 like 100129361 LOC100129361 chromosome X −2.06 0.66 1.07 openreading frame 69-like 10742 RAI2 retinoic acid −2.06 −1.54 0.78 induced2 196264 MPZL3 myelin protein −2.06 −0.75 1.46 zero-like 3 27197 GPR82 Gprotein- −2.06 1.47 −0.05 coupled receptor 82 7529 YWHAB tyrosine 3-−2.06 0.12 1.88 monooxygenase/ tryptophan 5- monooxygenase activationprotein, beta polypeptide 94235 GNG8 guanine −2.06 0.86 1.60 nucleotidebinding protein (G protein), gamma 8 352961 HCG26 HLA complex −2.06 0.171.72 group 26 (non- protein coding) 49856 WRAP73 WD repeat −2.06 1.000.94 containing, antisense to TP73 9448 MAP4K4 mitogen- −2.06 −0.65 0.97activated protein kinase kinase kinase kinase 4 9525 VPS4B vacuolarprotein −2.06 −0.29 0.95 sorting 4 homolog B (S. cerevisiae) 100505576LINC00672 long intergenic −2.06 −0.31 0.81 non-protein coding RNA 672151556 GPR155 G protein- −2.06 −0.84 1.11 coupled receptor 155 284613CYB561D1 cytochrome −2.06 −0.29 1.00 b561 family, member D1 286223C9orf47 chromosome 9 −2.06 −0.06 −0.46 open reading frame 47 57061 HYMAIhydatidiform −2.06 −0.54 −1.51 mole associated and imprinted(non-protein coding) 9520 NPEPPS aminopeptidase −2.07 −0.18 0.60puromycin sensitive 202299 C5orf27 chromosome 5 −2.07 0.22 0.55 openreading frame 27 2015 EMR1 egf-like module −2.07 0.71 −0.20 containing,mucin-like, hormone receptor-like 1 57763 ANKRA2 ankyrin repeat, −2.071.06 1.86 family A (RFXANK- like), 2 54778 RNF111 ring finger −2.07 0.080.96 protein 111 762 CA4 carbonic −2.07 −1.35 0.56 anhydrase IV 192668CYS1 cystin 1 −2.08 0.29 0.23 24146 CLDN15 claudin 15 −2.08 0.77 1.3054843 SYTL2 synaptotagmin- −2.08 1.28 1.88 like 2 55374 TMCO6transmembrane −2.08 0.23 0.72 and coiled-coil domains 6 79603 CERS4ceramide −2.08 −0.79 1.36 synthase 4 3577 CXCR1 chemokine −2.08 −0.870.16 (C—X—C motif) receptor 1 10385 BTN2A2 butyrophilin, −2.08 2.47 0.07subfamily 2, member A2 79792 GSDMD gasdermin D −2.08 1.86 −0.51 84674CARD6 caspase −2.09 −0.39 0.54 recruitment domain family, member 6 51131PHF11 PHD finger −2.09 −0.26 1.37 protein 11 5966 REL v-rel avian −2.091.12 1.40 reticuloendotheliosis viral oncogene homolog 9733 SART3squamous cell −2.09 2.19 0.91 carcinoma antigen recognized by T cells 310328 EMC8 ER membrane −2.09 0.55 1.57 protein complex subunit 8 255231MCOLN2 mucolipin 2 −2.09 0.84 0.52 25801 GCA grancalcin, EF- −2.09 0.50−0.38 hand calcium binding protein 6352 CCL5 chemokine (C-C −2.09 0.662.04 motif) ligand 5 54811 ZNF562 zinc finger −2.09 0.02 0.03 protein562 59348 ZNF350 zinc finger −2.09 −0.38 1.17 protein 350 9967 THRAP3thyroid hormone −2.09 0.61 0.79 receptor associated protein 3 2533 FYBFYN binding −2.10 −0.93 1.62 protein 28985 MCTS1 malignant T cell −2.101.15 1.28 amplified sequence 1 55234 SMU1 smu-1 −2.10 −0.47 1.24suppressor of mec-8 and unc- 52 homolog (C. elegans) 1301 COL11A1collagen, type −2.10 1.40 −0.09 XI, alpha 1 84803 AGPAT9 1-acylglycerol-−2.10 0.07 0.36 3-phosphate O- acyltransferase 9 100506779 BZRAP1-BZRAP1 −2.10 −0.30 1.43 AS1 antisense RNA 1 197135 PATL2 protein −2.10−0.32 1.45 associated with topoisomerase II homolog 2 (yeast) 3614IMPDH1 IMP (inosine 5′- −2.10 −0.75 −0.34 monophosphate) dehydrogenase 180781 COL18A1 collagen, type −2.10 0.13 0.76 XVIII, alpha 1 5586 PKN2protein kinase −2.11 0.30 0.71 N2 79415 C17orf62 chromosome 17 −2.110.76 −0.67 open reading frame 62 8893 EIF2B5 eukaryotic −2.11 1.21 1.89translation initiation factor 2B, subunit 5 epsilon, 82 kDa 79736 TEFMtranscription −2.11 1.33 0.37 elongation factor, mitochondrial 5770PTPN1 protein tyrosine −2.11 2.04 −0.16 phosphatase, non-receptor type 19360 PPIG peptidylprolyl −2.11 0.97 1.56 isomerase G (cyclophilin G)29940 DSE dermatan sulfate −2.11 0.87 0.10 epimerase 7150 TOP1topoisomerase −2.11 2.04 −0.62 (DNA) I 84964 ALKBH6 alkB, alkylation−2.11 1.92 −0.46 repair homolog 6 (E. coli) 10614 HEXIM1 hexamethylene−2.11 0.25 1.20 bis-acetamide inducible 1 147923 ZNF420 zinc finger−2.12 0.88 1.70 protein 420 284029 LINC00324 long intergenic −2.12 −1.081.66 non-protein coding RNA 324 54952 TRNAU1AP tRNA −2.12 −0.15 1.42selenocysteine 1 associated protein 1 57476 GRAMD1B GRAM domain −2.12−0.38 0.44 containing 1B 8745 ADAM23 ADAM −2.12 2.31 0.05metallopeptidase domain 23 22928 SEPHS2 selenophosphate −2.12 0.67 0.44synthetase 2 25880 TMEM186 transmembrane −2.12 1.09 1.51 protein 18628638 TRBC2 T cell receptor −2.12 −0.78 2.11 beta constant 2 29933GPR132 G protein- −2.12 0.04 1.76 coupled receptor 132 30009 TBX21 T-box21 −2.12 0.92 0.97 3554 ILIR1 interleukin 1 −2.12 0.44 0.16 receptor,type I 8821 INPP4B inositol −2.12 1.75 1.83 polyphosphate-4-phosphatase, type II, 105 kDa 10943 MSL3 male-specific −2.12 −0.771.06 lethal 3 homolog (Drosophila) 57724 EPG5 ectopic P- −2.12 −0.140.63 granules autophagy protein 5 homolog (C. elegans) 100506282LOC100506282 uncharacterized −2.13 1.67 0.76 LOC100506282 147699 PPM1Nprotein −2.13 0.16 0.53 phosphatase, Mg2+/Mn2+ dependent, 1 N (putative)3002 GZMB granzyme B −2.13 0.76 0.87 (granzyme 2, cytotoxic T-lymphocyte- associated serine esterase 1) 389320 C5orf48 chromosome 5−2.13 0.37 1.37 open reading frame 48 9914 ATP2C2 ATPase, Ca++ −2.130.23 1.12 transporting, type 2C, member 2 10804 GJB6 gap junction −2.13−1.12 1.65 protein, beta 6, 30 kDa 51439 FAM8A1 family with −2.13 −0.891.07 sequence similarity 8, member A1 814 CAMK4 calcium/calmodulin-−2.13 −0.47 2.19 dependent protein kinase IV 5272 SERPINB9 serpinpeptidase −2.13 −0.34 0.40 inhibitor, clade B (ovalbumin), member 9 8428STK24 serine/threonine −2.13 −1.09 1.59 kinase 24 23048 FNBP1 forminbinding −2.14 1.36 0.52 protein 1 344558 SH3RF3 SH3 domain −2.14 −0.731.32 containing ring finger 3 79078 C1orf50 chromosome 1 −2.14 0.08 1.02open reading frame 50 81606 LBH limb bud and −2.14 0.57 2.63 heartdevelopment 64377 CHST8 carbohydrate −2.14 0.58 −0.51 (N-acetylgalactosamine 4-0) sulfotransferase 8 57501 KIAA1257 KIAA1257−2.14 −0.10 0.47 5991 RFX3 regulatory factor −2.14 1.47 1.11 X, 3(influences HLA class II expression) 90075 ZNF30 zinc finger −2.14 1.821.22 protein 30 375341 C3orf62 chromosome 3 −2.14 −0.26 0.66 openreading frame 62 100130548 LOC100130548 uncharacterized −2.15 −0.64 1.52LOC100130548 114786 XKR4 XK, Kell blood −2.15 0.58 −0.23 group complexsubunit-related family, member 4 150084 IGSF5 immunoglobulin −2.15 0.75−0.16 superfamily, member 5 55012 PPP2R3C protein −2.15 −0.91 0.93phosphatase 2, regulatory subunit B″, gamma 147525 LINC00526 longintergenic −2.15 −0.23 1.84 non-protein coding RNA 526 54557 SGTB smallglutamine- −2.15 −0.86 0.84 rich tetratricopeptide repeat (TPR)-containing, beta 56267 CCBL2 cysteine −2.15 0.21 1.69 conjugate-betalyase 2 51176 LEF1 lymphoid −2.15 −1.11 2.08 enhancer- binding factor 110468 FST follistatin −2.15 −0.19 2.02 23258 DENND5A DENN/MADD −2.15−0.31 0.08 domain containing 5A 90768 MGC45800 uncharacterized −2.15−0.26 1.01 LOC90768 134957 STXBP5 syntaxin binding −2.16 0.06 0.64protein 5 (tomosyn) 80342 TRAF3IP3 TRAF3 −2.16 −0.07 1.61 interactingprotein 3 91351 DDX60L DEAD (Asp- −2.16 −0.99 0.41 Glu-Ala-Asp) boxpolypeptide 60-like 29916 SNX11 sorting nexin 11 −2.16 −0.18 −0.11 8519IFITM1 interferon −2.16 −0.67 1.50 induced transmembrane protein 1 2113ETS1 v-ets avian −2.16 −0.80 1.75 erythroblastosis virus E26 oncogenehomolog 1 55770 EXOC2 exocyst complex −2.16 1.87 1.84 component 2 91833WDR20 WD repeat −2.16 −0.21 1.84 domain 20 117177 RAB3IP RAB3A −2.16−0.62 0.78 interacting protein 546 ATRX alpha −2.16 0.55 0.60thalassemia/mental retardation syndrome X- linked 4253 CTAGE5 CTAGEfamily, −2.17 0.57 0.77 member 5 23214 XPO6 exportin 6 −2.17 −1.37 1.0053347 UBASH3A ubiquitin −2.17 −1.35 2.45 associated and SH3 domaincontaining A 56888 KCMF1 potassium −2.17 0.00 0.23 channel modulatoryfactor 1 777 CACNA1E calcium channel, −2.17 −0.20 0.28 voltage-dependent, R type, alpha 1E subunit 100216545 KMT2E- KMT2E −2.17 0.712.04 AS1 antisense RNA1 (head to head) 8879 SGPL1 sphingosine-1- −2.171.73 −0.25 phosphate lyase 1 9759 HDAC4 histone −2.17 −2.02 1.08deacetylase 4 26578 OSTF1 osteoclast −2.18 −0.80 0.56 stimulating factor1 4050 LTB lymphotoxin −2.18 −1.06 1.52 beta (TNF superfamily, member 3)4236 MFAP1 microfibrillar- −2.18 0.60 0.85 associated protein 1 54491FAM105A family with −2.18 −0.93 1.49 sequence similarity 105, member A55847 CISD1 CDGSH iron −2.18 0.64 1.22 sulfur domain 1 100132707 PAXIP1-PAXIP1 −2.19 0.24 0.73 AS2 antisense RNA 2 55884 WSB2 WD repeat and−2.19 0.99 −0.17 SOCS box containing 2 83607 AMMECR1L AMMECR1-like −2.191.07 1.60 9252 RPS6KA5 ribosomal −2.19 −0.18 0.95 protein S6 kinase, 90kDa, polypeptide 5 55119 PRPF38B pre-mRNA −2.19 1.71 1.08 processingfactor 38B 57520 HECW2 HECT, C2 and −2.19 0.30 0.43 WW domain containingE3 ubiquitin protein ligase 2 79818 ZNF552 zinc finger −2.19 −1.20 1.23protein 552 8320 EOMES eomesodermin −2.19 0.15 1.44 2792 GNGT1 guanine−2.19 1.41 −0.14 nucleotide binding protein (G protein), gammatransducing activity polypeptide 1 54910 SEMA4C sema domain, −2.19 1.210.99 immunoglobulin domain (Ig), transmembrane domain (TM) and shortcytoplasmic domain, (semaphorin) 4C 55114 ARHGAP17 Rho GTPase −2.19 0.18−0.27 activating protein 17 56253 CRTAM cytotoxic and −2.19 0.83 1.31regulatory T cell molecule 65082 VPS33A vacuolar protein −2.19 −0.651.18 sorting 33 homolog A (S. cerevisiae) 84719 LINC00260 longintergenic −2.20 1.45 1.51 non-protein coding RNA 260 253558 LCLAT1lysocardiolipin −2.20 0.62 0.95 acyltransferase 1 6777 STAT5B signal−2.20 −0.54 1.15 transducer and activator of transcription 5B 80025PANK2 pantothenate −2.20 −0.45 0.85 kinase 2 84662 GLIS2 GLIS family−2.20 0.95 0.42 zinc finger 2 89890 KBTBD6 kelch repeat and −2.20 0.031.98 BTB (POZ) domain containing 6 10390 CEPT1 choline/ethanolamine−2.20 0.35 1.23 phosphotransferase 1 2841 GPR18 G protein- −2.20 1.152.42 coupled receptor 18 3904 LAIR2 leukocyte- −2.20 0.84 0.21associated immunoglobulin- like receptor 2 140460 ASB7 ankyrin repeat−2.20 0.07 1.03 and SOCS box containing 7 9605 VPS9D1 VPS9 domain −2.20−0.23 0.95 containing 1 283349 RASSF3 Ras association −2.21 −0.83 0.96(RalGDS/AF-6) domain family member 3 51246 SHISA5 shisa family −2.21−1.42 0.99 member 5 148268 ZNF570 zinc finger −2.21 1.26 2.25 protein570 26589 MRPL46 mitochondrial −2.21 1.15 1.68 ribosomal protein L467049 TGFBR3 transforming −2.21 1.01 2.02 growth factor, beta receptorIII 2791 GNG11 guanine −2.21 −0.39 −0.02 nucleotide binding protein (Gprotein), gamma 11 51455 REV1 REV1, −2.21 1.24 1.77 polymerase (DNAdirected) 1178 CLC Charcot-Leyden −2.22 0.06 0.48 crystal galectin 79153GDPD3 glycerophosphodiester −2.22 −0.34 0.91 phosphodiesterase domaincontaining 3 101928524 LOC101928524 uncharacterized −2.22 −0.67 0.78LOC101928524 11064 CNTRL centriolin −2.22 0.66 −0.56 23429 RYBP RING1and −2.22 1.35 0.64 YY1 binding protein 5170 PDPK1 3- −2.22 −0.83 0.31phosphoinositide dependent protein kinase-1 10677 AVIL advillin −2.23−0.85 0.84 3772 KCNJ15 potassium −2.23 −1.08 0.27 inwardly- rectifyingchannel, subfamily J, member 15 128061 C1orf131 chromosome 1 −2.23 0.811.10 open reading frame 131 50856 CLEC4A C-type lectin −2.23 −0.08 −0.28domain family 4, member A 6198 RPS6KB1 ribosomal −2.23 2.01 1.73 proteinS6 kinase, 70 kDa, polypeptide 1 101927588 LOC101927588 uncharacterized−2.24 −0.02 0.56 LOC101927588 2000 ELF4 E74-like factor 4 −2.24 0.130.14 (ets domain transcription factor) 493753 COA5 cytochrome c −2.240.79 1.30 oxidase assembly factor 5 23081 KDM4C lysine (K)- −2.24 1.090.42 specific demethylase 4C 4773 NFATC2 nuclear factor of −2.24 0.571.16 activated T- cells, cytoplasmic, calcineurin- dependent 2 10178TENM1 teneurin −2.25 −0.87 0.62 transmembrane protein 1 4974 OMGoligodendrocyte −2.25 −1.43 0.63 myelin glycoprotein 83860 TAF3 TAF3 RNA−2.25 0.03 1.69 polymerase II, TATA box binding protein (TBP)-associated factor, 140 kDa 91612 CHURC1 churchill −2.25 −1.11 1.06domain containing 1 2178 FANCE Fanconi anemia, −2.26 −0.72 0.82complementation group E 55303 GIMAP4 GTPase, IMAP −2.26 −0.40 1.33family member 4 221002 RASGEF1A RasGEF domain −2.26 −0.14 0.69 family,member 1A 3930 LBR lamin B receptor −2.26 0.12 0.71 55471 NDUFAF7 NADH−2.26 1.20 1.05 dehydrogenase (ubiquinone) complex I, assembly factor 79354 UBE4A ubiquitination −2.26 0.81 0.66 factor E4A 83700 JAM3junctional −2.26 −0.33 1.46 adhesion molecule 3 9140 ATG12 autophagy−2.26 1.06 0.85 related 12 23526 HMHA1 histocompatibility −2.27 0.141.43 (minor) HA-1 23590 PDSS1 prenyl −2.27 0.01 0.69 (decaprenyl)diphosphate synthase, subunit 1 9270 ITGB1BP1 integrin beta 1 −2.27 1.680.62 binding protein 1 10627 MYL12A myosin, light −2.27 −0.87 1.16 chain12A, regulatory, non- sarcomeric 26048 ZNF500 zinc finger −2.27 3.471.42 protein 500 917 CD3G CD3g molecule, −2.27 −0.29 2.30 gamma (CD3-TCR complex) 94039 ZNF101 zinc finger −2.27 −0.72 1.69 protein 101 4215MAP3K3 mitogen- −2.28 −0.81 1.06 activated protein kinase kinase kinase3 10663 CXCR6 chemokine −2.28 0.37 1.78 (C—X—C motif) receptor 6 10308ZNF267 zinc finger −2.28 0.38 0.74 protein 267 8527 DGKD diacylglycerol−2.28 0.75 1.41 kinase, delta 130 kDa 926 CD8B CD8b molecule −2.28 −0.832.69 9619 ABCG1 ATP-binding −2.28 0.94 1.01 cassette, sub- family G(WHITE), member 1 5998 RGS3 regulator of G- −2.29 −0.40 0.51 proteinsignaling 3 132625 ZFP42 ZFP42 zinc −2.29 0.10 1.45 finger protein 88455ANKRD13A ankyrin repeat −2.30 −0.39 0.13 domain 13A 3604 TNFRSF9 tumornecrosis −2.30 −0.59 0.42 factor receptor superfamily, member 9100507398 INTS6- INTS6 antisense −2.30 1.02 1.07 AS1 RNA 1 58517 RBM25RNA binding −2.30 2.48 1.59 motif protein 25 51192 CKLF chemokine-like−2.31 −0.45 0.59 factor 2177 FANCD2 Fanconi anemia, −2.31 1.14 1.23complementation group D2 57097 PARP11 poly (ADP- −2.31 −0.19 0.77ribose) polymerase family, member 11 11214 AKAP13 A kinase −2.31 0.370.68 (PRKA) anchor protein 13 4600 MX2 myxovirus −2.31 −1.58 0.05(influenza virus) resistance 2 (mouse) 84255 SLC37A3 solute carrier−2.31 −0.59 0.93 family 37, member 3 11216 AKAP10 A kinase −2.32 0.821.04 (PRKA) anchor protein 10 162417 NAGS N- −2.32 0.09 1.46acetylglutamate synthase 101928617 LOC101928617 uncharacterized −2.32−0.30 0.64 LOC101928617 10617 STAMBP STAM binding −2.32 1.84 −0.17protein 1326 MAP3K8 mitogen- −2.32 0.72 0.63 activated protein kinasekinase kinase 8 23315 SLC9A8 solute carrier −2.32 −1.35 0.88 family 9,subfamily A (NHE8, cation proton antiporter 8), member 8 10791 VAMP5vesicle- −2.32 −0.11 1.36 associated membrane protein 5 8718 TNFRSF25tumor necrosis −2.32 −0.24 3.91 factor receptor superfamily, member 2551571 FAM49B family with −2.33 −0.68 0.75 sequence similarity 49, memberB 283521 LINC00282 long intergenic −2.33 −2.30 1.78 non-protein codingRNA 282 51122 COMMD2 COMM domain −2.33 −0.09 1.53 containing 2 5372 PMM1phosphomanno −2.33 0.16 1.25 mutase 1 9830 TRIM14 tripartite motif −2.33−0.29 1.44 containing 14 314 AOC2 amine oxidase, −2.33 −0.52 0.23 coppercontaining 2 (retina-specific) 51761 ATP8A2 ATPase, −2.33 0.45 1.61aminophospholipid transporter, class I, type 8A, member 2 493861 EID3EP300 −2.34 0.84 1.87 interacting inhibitor of differentiation 3 6672SP100 SP100 nuclear −2.34 −0.15 0.33 antigen 55578 SUPT20H suppressor ofTy −2.34 −0.88 2.05 20 homolog (S. cerevisiae) 159 ADSS adenylosuccinate−2.34 1.28 1.03 synthase 9683 N4BP1 NEDD4 binding −2.34 −0.82 0.93protein 1 26287 ANKRD2 ankyrin repeat −2.35 0.96 −1.11 domain 2 (stretchresponsive muscle) 57147 SCYL3 SCY1-like 3 (S. cerevisiae) −2.35 0.411.20 1808 DPYSL2 dihydropyrimidinase- −2.35 0.81 −0.69 like 2 23355 VPS8vacuolar protein −2.35 −0.37 0.18 sorting 8 homolog (S. cerevisiae) 8115TCL1A T-cell −2.35 0.02 0.58 leukemia/lymphoma 1A 94120 SYTL3synaptotagmin- −2.35 0.66 1.11 like 3 22950 SLC4A1AP solute carrier−2.35 −0.93 1.36 family 4 (anion exchanger), member 1, adaptor protein27342 RABGEF1 RAB guanine −2.35 −0.93 1.58 nucleotide exchange factor(GEF)1 64926 RASAL3 RAS protein −2.35 0.01 0.96 activator like 3100507331 ZSWIM8- ZSWIM8 −2.36 0.57 1.26 AS1 antisense RNA 1 4068 SH2D1ASH2 domain −2.36 1.66 1.54 containing 1A 60481 ELOVL5 ELOVL fatty −2.361.02 0.79 acid elongase 5 2634 GBP2 guanylate −2.36 0.00 0.80 bindingprotein 2, interferon- inducible 55824 PAG1 phosphoprotein −2.36 −1.031.59 associated with glycosphingolipid microdomains 1 79074 C2orf49chromosome 2 −2.36 1.44 0.56 open reading frame 49 220930 ZEB1- ZEB1antisense −2.36 1.06 0.36 AS1 RNA 1 64421 DCLRE1C DNA cross-link −2.360.49 0.61 repair 1C 64121 RRAGC Ras-related GTP −2.37 0.32 0.40 bindingC 137835 TMEM71 transmembrane −2.37 −0.41 1.11 protein 71 57674 RNF213ring finger −2.37 −0.91 0.53 protein 213 728392 LOC728392uncharacterized −2.37 −0.94 0.78 LOC728392 329 BIRC2 baculoviral IAP−2.38 1.72 1.94 repeat containing 2 55279 ZNF654 zinc finger −2.38 0.071.10 protein 654 7107 GPR137B G protein- −2.38 0.57 0.21 coupledreceptor 137B 9416 DDX23 DEAD (Asp- −2.38 0.21 0.21 Glu-Ala-Asp) boxpolypeptide 23 137964 AGPAT6 1-acylglycerol- −2.38 1.36 0.99 3-phosphateO- acyltransferase 6 3431 SP110 SP110 nuclear −2.38 −0.53 0.24 bodyprotein 4140 MARK3 MAP/microtubule −2.38 1.19 0.52 affinity- regulatingkinase 3 59269 HIVEP3 human −2.38 0.24 0.53 immunodeficiency virus typeI enhancer binding protein 3 7846 TUBA1A tubulin, alpha 1a −2.38 0.540.04 100652740 C16orf98 chromosome 16 −2.38 0.57 1.13 open reading frame98 23398 PPWD1 peptidylprolyl −2.38 0.94 1.67 isomerase domain and WDrepeat containing 1 158747 MOSPD2 motile sperm −2.39 −0.04 0.20 domaincontaining 2 285512 FAM13A- FAM13A −2.39 0.05 0.98 AS1 antisense RNA 13937 LCP2 lymphocyte −2.39 0.47 1.08 cytosolic protein 2 (SH2 domaincontaining leukocyte protein of 76 kDa) 730051 ZNF814 zinc finger −2.390.33 1.83 protein 814 9320 TRIP12 thyroid hormone −2.39 1.30 0.94receptor interactor 12 6932 TCF7 transcription −2.39 −0.88 2.43 factor 7(T-cell specific, HMG- box) 79722 ANKRD55 ankyrin repeat −2.39 −0.591.57 domain 55 115362 GBP5 guanylate −2.39 −0.13 0.78 binding protein 529909 GPR171 G protein- −2.39 −0.05 2.07 coupled receptor 171 440503PLIN5 perilipin 5 −2.40 −0.13 −0.04 80183 KIAA0226L KIAA0226-like −2.40−0.11 −0.47 80709 AKNA AT-hook −2.40 −0.40 1.34 transcription factor10562 OLFM4 olfactomedin 4 −2.40 −0.72 1.37 64780 MICAL1 microtubule−2.41 0.90 −0.01 associated monooxygenase, calponin and LIM domaincontaining 1 155038 GIMAP8 GTPase, IMAP −2.41 −0.08 1.03 family member 81783 DYNC1L12 dynein, −2.41 0.29 0.55 cytoplasmic 1, light intermediatechain 2 100287569 LINC00173 long intergenic −2.42 0.79 0.50 non-proteincoding RNA 173 5696 PSMB8 proteasome −2.42 1.75 1.55 (prosome,macropain) subunit, beta type, 8 11066 SNRNP35 small nuclear −2.42 −0.970.66 ribonucleoprotein 35 kDa (U11/U12) 122553 TRAPPC6B trafficking−2.42 1.80 0.59 protein particle complex 6B 50484 RRM2B ribonucleotide−2.43 0.68 0.40 reductase M2 B (TP53 inducible) 9847 C2CD5 C2 calcium-−2.43 −0.31 1.91 dependent domain containing 5 129285 PPP1R21 protein−2.43 0.25 0.06 phosphatase 1, regulatory subunit 21 9794 MAML1mastermind-like −2.43 −0.49 1.65 1 (Drosophila) 84309 NUDT16L1 nudix−2.43 0.68 1.62 (nucleoside diphosphate linked moiety X)-type motif16-like 1 65258 MPPE1 metallophosphoesterase 1 −2.43 0.07 0.99 5562PRKAA1 protein kinase, −2.44 0.73 0.77 AMP-activated, alpha 1 catalyticsubunit 123036 TC2N tandem C2 −2.44 −0.21 2.02 domains, nuclear 84166NLRC5 NLR family, −2.45 −0.28 1.58 CARD domain containing 5 253143PRR14L proline rich 14- −2.45 0.27 −0.17 like 1236 CCR7 chemokine (C-C−2.45 0.54 2.19 motif) receptor 7 266747 RGL4 ral guanine −2.46 −1.201.65 nucleotide dissociation stimulator-like 4 25988 HINFP histone H4−2.46 1.72 0.72 transcription factor 6515 SLC2A3 solute carrier −2.46−0.20 0.92 family 2 (facilitated glucose transporter), member 3 90592ZNF700 zinc finger −2.46 −0.40 0.59 protein 700 6867 TACC1 transforming,−2.47 0.01 1.16 acidic coiled- coil containing protein 1 23041 MON2 MON2homolog −2.47 0.67 1.20 (S. cerevisiae) 100289230 LOC100289230uncharacterized −2.47 0.61 2.09 LOC100289230 57169 ZNFX1 zinc finger,−2.48 −0.54 0.80 NFX1-type containing 1 1105 CHD1 chromodomain −2.480.28 1.87 helicase DNA binding protein 1 943 TNFRSF8 tumor necrosis−2.48 1.74 −0.67 factor receptor superfamily, member 8 3275 PRMT2protein arginine −2.48 −0.49 1.32 methyltransferase 2 8851 CDK5R1cyclin- −2.49 −0.76 2.06 dependent kinase 5, regulatory subunit 1 (p35)168537 GIMAP7 GTPase, IMAP −2.49 0.04 1.78 family member 7 256236 NAPSBnapsin B −2.49 1.72 −0.85 aspartic peptidase, pseudogene 26235 FBXL4F-box and −2.50 1.20 −0.11 leucine-rich repeat protein 4 9363 RAB33ARAB33A, −2.50 0.55 2.57 member RAS oncogene family 729683 LOC729683uncharacterized −2.50 0.55 1.35 LOC729683 388969 C2orf68 chromosome 2−2.51 0.77 1.38 open reading frame 68 4818 NKG7 natural killer −2.510.44 1.69 cell group 7 sequence 93953 ACRC acidic repeat −2.51 0.38 1.86containing 28982 FLVCR1 feline leukemia −2.51 1.33 0.57 virus subgroup Ccellular receptor 1 84911 ZNF382 zinc finger −2.52 1.69 1.32 protein 38266036 MTMR9 myotubularin −2.52 −0.10 1.66 related protein 9 9750 FAM65Bfamily with −2.52 −0.37 1.14 sequence similarity 65, member B 9938ARHGAP25 Rho GTPase −2.52 0.29 0.14 activating protein 25 120425 AMICA1adhesion −2.52 −0.42 0.68 molecule, interacts with CXADR antigen 1 6840SVIL supervillin −2.53 −0.64 0.50 26268 FBXO9 F-box protein 9 −2.53 0.691.35 55206 SBNO1 strawberry notch −2.53 −0.54 1.57 homolog 1(Drosophila) 355 FAS Fas cell surface −2.54 0.43 0.39 death receptor50615 IL21R interleukin 21 −2.54 0.35 1.97 receptor 221178 SPATA13spermatogenesis −2.54 −2.61 1.22 associated 13 11104 KATNA1 katanin p60−2.54 0.20 2.21 (ATPase containing) subunit A1 1117 CHI3L2 chitinase3-like 2 −2.54 0.52 1.23 374969 CCDC23 coiled-coil −2.54 −1.26 1.25domain containing 23 6285 S100B S100 calcium −2.55 1.40 1.92 bindingprotein B 387357 THEMIS thymocyte −2.55 −0.15 1.81 selection associated2960 GTF2E1 general −2.56 0.13 0.92 transcription factor IIE,polypeptide 1, alpha 56 kDa 100129550 LOC100129550 uncharacterized −2.56−0.15 0.93 LOC100129550 54520 CCDC93 coiled-coil −2.56 −1.12 2.30 domaincontaining 93 10302 SNAPC5 small nuclear −2.56 0.07 1.15 RNA activatingcomplex, polypeptide 5, 19 kDa 50939 IMPG2 interphotoreceptor −2.56 1.121.76 matrix proteoglycan 2 8802 SUCLG1 succinate-CoA −2.56 2.64 1.54ligase, alpha subunit 23332 CLASP1 cytoplasmic −2.57 1.26 2.20 linkerassociated protein 1 203328 SUSD3 sushi domain −2.57 −0.72 2.46containing 3 126231 ZNF573 zinc finger −2.58 0.65 1.46 protein 573 6993DYNLT1 dynein, light −2.58 −0.49 1.03 chain, Tctex- type 1 58500 ZNF250zinc finger −2.59 −0.24 0.92 protein 250 10507 SEMA4D sema domain, −2.59−1.16 1.46 immunoglobulin domain (Ig), transmembrane domain (TM) andshort cytoplasmic domain, (semaphorin) 4D 170482 CLEC4C C-type lectin−2.59 −0.58 0.36 domain family 4, member C 3004 GZMM granzyme M −2.591.40 2.20 (lymphocyte met-ase 1) 64895 PAPOLG poly(A) −2.59 1.43 0.78polymerase gamma 7850 IL1R2 interleukin 1 −2.59 0.45 0.05 receptor, typeII 93594 TBC1D31 TBC1 domain −2.59 0.76 0.44 family, member 31 23215PRRC2C proline-rich −2.60 −0.05 1.60 coiled-coil 2C 80196 RNF34 ringfinger −2.60 0.73 1.11 protein 34, E3 ubiquitin protein ligase 284415VSTM1 V-set and −2.60 −0.29 0.72 transmembrane domain containing 1 56882CDC42SE1 CDC42 small −2.60 −0.64 1.52 effector 1 6508 SLC4A3 solutecarrier −2.60 0.54 0.57 family 4 (anion exchanger), member 3 79663HSPBAP1 HSPB (heat −2.61 −0.64 0.48 shock 27 kDa) associated protein 1474344 GIMAP6 GTPase, IMAP −2.61 0.08 1.31 family member 6 100505746ITGB2- ITGB2 antisense −2.62 0.00 0.48 AS1 RNA 1 1293 COL6A3 collagentype −2.62 1.08 0.33 VI, alpha 3 10294 DNAJA2 DnaJ (Hsp40) −2.62 −0.420.80 homolog, subfamily A, member 2 3091 HIF1A hypoxia −2.62 0.89 0.98inducible factor 1, alpha subunit (basic helix- loop-helix transcriptionfactor) 79573 TTC13 tetratricopeptide −2.63 −0.03 1.77 repeat domain 139208 LRRFIP1 leucine rich −2.63 1.90 0.55 repeat (in FLII) interactingprotein 1 29116 MYLIP myosin −2.63 0.05 1.36 regulatory light chaininteracting protein 92370 ACPL2 acid −2.63 0.23 1.78 phosphatase-like 29546 APBA3 amyloid beta −2.64 0.44 0.47 (A4) precursor protein-binding,family A, member 3 253018 HCG27 HLA complex −2.64 −0.10 1.10 group 27(non- protein coding) 10096 ACTR3 ARP3 actin- −2.65 1.04 −0.12 relatedprotein 3 homolog (yeast) 84138 SLC7A6OS solute carrier −2.65 0.77 0.59family 7, member 6 opposite strand 8440 NCK2 NCK adaptor −2.65 0.72 1.76protein 2 7277 TUBA4A tubulin, alpha 4a −2.65 −0.26 1.61 8269 TMEM187transmembrane −2.66 0.48 0.64 protein 187 8807 IL18RAP interleukin 18−2.66 −0.44 1.01 receptor accessory protein 1235 CCR6 chemokine (C-C−2.67 1.38 2.29 motif) receptor 6 7059 THBS3 thrombospondin 3 −2.67 0.990.61 54971 BANP BTG3 −2.67 −0.13 1.08 associated nuclear protein 57677ZFP14 ZFP14 zinc −2.68 1.28 1.43 finger protein 6890 TAP1 transporter 1,−2.68 0.01 1.23 ATP-binding cassette, sub- family B (MDR/TAP) 22944 KINKIN, antigenic −2.69 0.44 1.04 determinant of recA protein homolog(mouse) 26512 INTS6 integrator −2.69 0.30 0.91 complex subunit 6 92797HELB helicase (DNA) B −2.69 0.69 0.21 5481 PPID peptidylprolyl −2.700.46 0.93 isomerase D 22897 CEP164 centrosomal −2.71 −0.13 0.44 protein164 kDa 3620 IDO1 indoleamine 2,3- −2.71 0.37 0.85 dioxygenase 1 64766S100PBP S100P binding −2.71 1.02 0.38 protein 8809 IL18R1 interleukin 18−2.71 −0.63 1.28 receptor 1 116984 ARAP2 ArfGAP with −2.71 0.12 1.76RhoGAP domain, ankyrin repeat and PH domain 2 440823 MIAT myocardial−2.72 1.47 1.42 infarction associated transcript (non- protein coding)59340 HRH4 histamine −2.72 1.07 0.24 receptor H4 197259 MLKL mixedlineage −2.73 0.14 −0.03 kinase domain- like 23670 TMEM2 transmembrane−2.73 −0.89 1.36 protein 2 643314 KIAA0754 KIAA0754 −2.73 1.42 −0.2028526 TRDC T cell receptor −2.73 0.84 1.43 delta constant 55096 EBLN2endogenous −2.74 0.08 1.21 Bornavirus-like nucleoprotein 2 2796 GNRH1gonadotropin- −2.74 1.82 0.79 releasing hormone 1 (luteinizing-releasing hormone) 54509 RHOF ras homolog −2.74 2.02 1.91 family memberF (in filopodia) 11120 BTN2A1 butyrophilin, −2.75 0.47 1.81 subfamily 2,member A1 84869 CBR4 carbonyl −2.75 1.20 0.13 reductase 4 28991 COMMD5COMM domain −2.76 0.53 0.53 containing 5 154141 MBOAT1 membrane −2.790.40 0.42 bound O- acyltransferase domain containing 1 3659 IRF1interferon −2.79 0.33 1.23 regulatory factor 1 154007 SNRNP48 smallnuclear −2.80 0.64 0.71 ribonucleoprotein 48 kDa (U11/U12) 116835HSPA12B heat shock 70 kD −2.81 0.73 0.95 protein 12B 9488 PIGBphosphatidylinositol −2.82 −0.03 1.02 glycan anchor biosynthesis, classB 100293516 ZNF587B zinc finger −2.83 −0.05 0.73 protein 587B 9217 VAPBVAMP (vesicle- −2.84 0.11 1.97 associated membrane protein)- associatedprotein B and C 10538 BATF basic leucine −2.84 0.90 0.63 zippertranscription factor, ATF-like 6935 ZEB1 zinc finger E- −2.87 0.92 1.75box binding homeobox 1 10443 N4BP2L2 NEDD4 binding −2.88 0.79 1.38protein 2-like 2 3837 KPNB1 karyopherin −2.88 0.72 0.69 (importin) beta1 81698 LINC00597 long intergenic −2.88 0.51 0.98 non-protein coding RNA597 2643 GCH1 GTP −2.89 1.47 1.66 cyclohydrolase 1 57559 STAMBPL1 STAMbinding −2.89 1.12 1.44 protein-like 1 116842 LEAP2 liver expressed−2.89 1.23 1.24 antimicrobial peptide 2 202 AIM1 absent in −2.90 −0.391.31 melanoma 1 9934 P2RY14 purinergic −2.90 0.39 0.49 receptor P2Y,G-protein coupled, 14 100216546 LINC01004 long intergenic −2.90 1.200.90 non-protein coding RNA 1004 9692 KIAA0391 KIAA0391 −2.90 1.44 1.4589845 ABCC10 ATP-binding −2.92 1.26 0.32 cassette, sub- family C(CFTR/MRP), member 10 26034 IPCEF1 interaction −2.92 −0.35 1.30 proteinfor cytohesin exchange factors 1 10906 TRAFD1 TRAF-type zinc −2.93 0.59−0.14 finger domain containing 1 84811 BUD13 BUD13 −2.94 0.68 2.47homolog (S. cerevisiae) 100527964 LOC100527964 uncharacterized −2.962.19 0.20 LOC100527964 118426 LOH12CR1 loss of −2.97 0.48 1.63heterozygosity, 12, chromosomal region 1 54331 GNG2 guanine −2.98 −0.030.87 nucleotide binding protein (G protein), gamma 2 94081 SFXN1sideroflexin 1 −2.99 0.80 1.65 145474 LOC145474 uncharacterized −2.99−0.36 0.65 LOC145474 84969 TOX2 TOX high −3.00 0.40 2.29 mobility groupbox family member 2 4907 NT5E 5′-nucleotidase, −3.02 1.48 0.94 ecto(CD73) 51735 RAPGEF6 Rap guanine −3.03 0.23 2.17 nucleotide exchangefactor (GEF) 6 9953 HS3ST3B1 heparan sulfate −3.03 0.28 1.28(glucosamine) 3-O- sulfotransferase 3B1 23112 TNRC6B trinucleotide −3.04−0.25 1.32 repeat containing 6B 91526 ANKRD44 ankyrin repeat −3.05 0.021.28 domain 44 101928017 LOC101928017 uncharacterized −3.08 1.33 2.56LOC101928017 84859 LRCH3 leucine-rich −3.08 1.45 0.64 repeats andcalponin homology (CH) domain containing 3 159013 CXorf38 chromosome X−3.11 −0.05 0.79 open reading frame 38 23208 SYT11 synaptotagmin −3.192.10 0.96 XI 101928649 LOC101928649 uncharacterized −3.23 2.32 0.72LOC101928649 85459 KIAA1731 KIAA1731 −3.28 0.85 0.74 9617 MTRF1mitochondrial −3.31 0.72 1.67 translational release factor 1 56898 BDH23- −3.50 1.08 1.68 hydroxybutyrate dehydrogenase, type 2 387882 C12orf75chromosome12 −3.61 1.40 1.07 open reading frame 75 677769 SCARNA17 smallCajal −3.64 1.73 0.35 body-specific RNA17 gene 22 23 24 25 26 27 28 2930 31 32 33 56904 −1.28 −1.83 −1.21 −1.05 −0.66 −0.43 −1.78 −0.69 −1.580.44 1.01 −0.76 6464 −0.81 −1.13 −1.00 −1.03 −0.56 −1.20 −0.33 −0.28−1.31 0.34 0.51 −0.13 79087 −0.31 −2.90 −0.53 −0.29 −0.66 −0.35 −0.03−0.18 −1.81 −0.22 0.44 −0.73 101928190 −1.47 −0.25 −1.19 −1.22 −0.40−0.39 −1.16 −0.67 0.23 0.08 −0.21 −0.22 3416 −0.59 −0.45 −1.01 −1.58−0.51 −0.95 −1.91 −0.71 0.15 −0.62 0.07 0.00 8001 −1.71 −0.80 −0.48−1.40 −1.24 0.01 −1.10 −1.56 −0.51 0.69 −0.22 −0.24 3727 −0.07 −1.14−1.52 −0.73 −1.41 −1.82 −1.51 −0.20 −1.07 1.02 0.47 −0.41 10945 0.01−0.88 −1.24 −1.27 −1.42 −0.93 −1.21 −0.26 −1.24 0.72 0.71 −1.17 5025−0.87 −0.79 −1.00 −1.24 −0.59 −0.49 −1.65 −0.52 −1.23 −0.24 1.11 −0.7629920 −1.54 −2.73 −0.24 −0.34 0.17 −0.54 −1.47 −0.54 −0.92 −0.26 1.050.64 101929248 −0.47 −0.98 −0.65 −0.85 −0.61 −1.35 −0.22 −0.65 −2.54−0.18 −0.62 0.23 23646 0.25 −1.68 −1.32 −0.48 −0.76 −0.64 −1.76 −0.22−1.69 0.35 0.61 −0.46 10280 −0.02 −1.39 −2.09 −0.07 −0.19 −0.76 −1.03−0.53 −1.88 0.14 0.20 0.17 140699 −0.57 −1.14 −1.47 −0.35 0.30 −0.45−0.69 −0.25 −0.56 −0.93 −0.15 0.62 4669 −0.47 −1.76 −1.51 −0.69 −0.46−0.80 −0.95 −0.60 −1.13 0.61 −0.69 −1.08 8341 −1.79 −0.53 −0.66 −2.02−0.06 −0.55 −1.55 0.83 0.33 0.10 −1.31 −0.85 2519 −0.08 −0.83 −0.05−0.54 −0.22 −0.07 −0.77 −0.76 −0.44 −1.20 0.37 −0.76 8985 −0.65 −0.90−1.85 −0.41 −0.45 −1.61 −1.23 −1.48 0.02 1.31 −0.16 −0.18 1690 0.48−0.84 −0.58 −1.09 −0.97 −2.01 −0.69 −0.58 0.82 −0.57 −0.36 −0.26 5111−0.47 −0.20 −1.68 −0.68 −2.12 −1.33 −0.96 −0.36 −0.56 −0.61 0.86 0.0955907 −0.94 −2.31 −0.59 0.30 −0.38 −1.00 −0.93 −0.24 −0.94 −0.46 −0.09−0.01 144811 −0.27 −1.17 −0.87 −0.18 −1.12 −0.19 −0.07 −1.80 0.53 −1.35−0.94 0.83 92421 −0.42 −2.35 −0.64 −0.34 −1.10 0.72 −1.28 −1.34 −1.09−0.85 1.39 −0.10 23475 −0.22 −0.75 −1.34 −0.29 −0.98 −1.44 −1.67 −1.38−0.50 0.13 −0.15 −1.58 54913 0.21 −1.45 −0.52 −0.96 −0.73 0.41 −1.10−0.99 −0.08 −1.89 1.72 0.18 4645 0.39 −0.57 −1.59 −1.36 −0.92 0.78 −1.14−0.16 −0.26 0.48 −0.44 −0.56 9917 −0.91 −1.04 −0.90 −0.17 −2.40 −0.36−0.74 −0.39 −0.28 −0.24 0.79 0.49 57213 −0.11 −0.01 −1.02 −0.38 −1.40−1.66 −0.89 −0.57 −0.24 0.64 −0.12 −0.12 113829 −1.00 −0.66 −0.97 −0.50−0.62 −0.35 −1.90 −1.13 −1.82 0.44 0.07 0.00 100128164 −0.93 −1.50 −1.29−0.90 −0.90 −0.44 −2.12 −0.20 0.18 1.48 −0.25 0.99 26284 −0.65 −1.15−1.48 −0.12 −1.63 −1.48 −1.39 −1.07 −0.54 0.46 −0.15 −0.42 64847 −0.62−1.92 −1.96 −0.13 −0.02 −0.58 −0.71 −1.04 −0.62 −0.12 −1.53 −0.35 559740.39 −1.37 −1.53 −0.83 0.39 −0.73 −1.67 0.03 −1.45 −0.84 0.27 −0.7764405 −2.30 0.28 −1.42 0.70 −1.02 −0.86 −0.51 −0.35 −0.10 −0.82 −0.530.03 6510 −0.02 −0.23 −1.46 −1.54 0.84 −1.10 −1.53 −1.06 −1.39 0.33 0.39−0.85 196463 −1.29 −0.53 0.13 −0.08 −0.93 −0.44 0.11 −0.72 −0.89 −0.78−1.26 −0.54 741 −1.37 −3.02 0.00 0.07 −0.16 0.09 −0.92 −0.36 −0.79 −0.99−0.83 −0.17 23568 −1.77 −0.16 −1.18 −0.81 −2.57 −0.51 −1.35 −1.08 −0.440.18 0.40 −0.47 79144 −1.35 −0.47 −1.91 −0.40 −0.61 −1.14 −0.69 −1.720.25 0.75 0.04 −0.05 91319 −0.94 1.17 −0.93 −1.11 −0.59 −1.45 −1.01−0.61 −1.22 0.69 −0.01 −0.98 79654 −0.42 −1.14 −1.00 −0.09 −1.03 −1.33−1.32 −1.46 0.30 0.85 −0.15 0.17 115950 −1.94 −0.21 −0.26 0.09 −1.180.55 −0.81 −2.66 −0.81 −0.28 −0.64 0.54 1374 −0.66 −1.14 0.77 −1.00−0.91 −1.78 −0.13 −0.16 0.02 −0.29 −1.12 −0.12 81533 0.04 −1.03 0.34−0.28 −2.54 0.09 −0.12 −0.45 −1.29 −0.70 0.74 −0.35 201931 −0.12 −0.79−0.56 −0.56 −1.24 −0.23 −0.93 −0.61 −1.18 −0.14 1.05 1.26 7979 −0.54−1.85 −1.60 −0.34 −0.51 −0.74 −2.66 −0.05 −1.07 0.47 0.57 0.10 159296−0.29 −2.23 −1.09 −0.47 −1.19 −1.19 −0.70 −1.29 −0.45 −1.48 0.39 0.4451102 −0.55 −1.70 −2.25 −0.26 0.01 −0.88 −1.89 −1.05 −1.02 0.73 −0.27−0.01 8729 −1.04 −2.12 −0.75 −0.91 0.64 −0.47 −1.75 −0.60 −1.64 0.811.01 −0.03 118460 −0.27 −1.68 −0.53 −0.13 −0.67 −1.68 −0.83 −0.05 −2.451.05 0.82 0.02 79586 −1.32 −0.05 −0.27 0.04 −0.77 −0.24 −1.94 −0.42 0.140.47 0.85 −1.27 2052 0.57 −0.57 −1.45 −0.72 −1.12 −0.34 −1.22 −1.19−0.72 −0.45 1.06 −0.72 84893 0.16 −1.13 −1.60 −0.80 1.38 −1.32 −0.62−0.94 −0.82 −0.21 −0.18 −0.09 54726 −0.91 −1.46 −0.26 −0.32 −0.48 0.01−0.61 −1.37 −0.16 −2.12 0.27 0.69 813 −0.41 −0.68 −1.55 −0.84 −0.35−0.55 −1.41 −0.79 −0.81 0.15 0.89 −0.93 54431 −0.24 −0.94 −1.36 −0.25−1.86 −0.57 −0.40 −0.67 0.04 −0.18 −0.12 0.19 9612 −1.40 −0.81 −0.67−1.56 −0.53 −2.17 0.00 −0.71 −0.15 1.43 0.81 −0.51 9829 −0.84 −1.18 0.51−0.02 −0.51 0.15 −0.61 0.37 0.70 −2.38 −0.42 −0.55 79036 −0.91 −1.36−1.06 −0.27 −0.70 −0.22 −1.02 −0.22 −0.39 1.03 0.00 −0.92 284361 −0.93−0.39 −1.29 −0.05 −1.87 −0.60 −1.53 −0.98 −1.21 0.35 0.79 −0.74 131118−0.21 −1.71 −1.73 −0.31 0.25 0.06 −1.88 −0.71 −0.67 0.06 −0.02 0.91644809 0.03 −0.72 −0.54 −1.48 0.15 −0.39 −0.20 −0.50 −1.93 −0.92 0.890.93 2119 −0.40 −0.52 −1.29 −0.50 −1.03 −0.50 −0.28 −0.92 −2.05 0.970.94 −1.10 5833 0.60 −0.87 −1.39 −0.89 −0.33 −1.09 −2.70 −0.29 −0.551.50 −0.13 −0.64 922 1.04 −1.78 −1.65 −0.19 −0.25 −1.34 −0.88 0.64 −2.09−0.07 −0.15 −0.01 9261 −0.37 −0.46 −0.25 −1.13 −1.38 −0.95 −0.90 0.00−2.42 1.26 1.47 −1.44 57190 0.58 −1.54 −0.12 −1.04 −1.51 −0.51 0.19−1.52 0.70 −0.67 1.23 −0.29 79644 −0.27 −0.81 −1.01 −0.45 −2.99 −0.84−0.84 −0.75 −0.73 −0.14 0.74 −0.03 79058 −0.68 −2.55 −1.65 −1.17 1.07−1.90 −1.07 −0.50 −1.01 0.76 −0.18 −0.25 7832 −0.75 −0.80 1.75 −0.97−1.72 0.60 −0.34 −0.58 −1.79 −1.22 0.20 −0.75 11070 −0.31 −1.85 −0.85−0.67 −1.96 0.67 −0.29 −1.12 −1.17 −1.09 0.85 −0.04 10847 −1.00 −0.84−0.94 −0.74 −0.27 −0.99 −1.16 −0.22 −0.68 2.32 0.59 −0.72 4597 −1.30−0.64 0.43 −0.66 0.62 −0.59 −1.03 −1.00 −0.89 −0.32 −0.72 −1.64100506696 −0.46 −0.28 −1.50 −0.99 −1.11 −1.28 −1.19 −1.05 −0.97 0.690.83 −0.65 100507459 0.13 −0.44 −1.72 −1.06 0.52 0.04 −1.09 −0.21 −1.810.60 0.41 −0.41 100130613 −0.55 −0.91 −0.72 −0.29 −1.82 −1.75 −1.36−0.10 −0.54 0.44 1.21 0.32 5081 −0.05 −2.10 −1.71 −0.98 0.31 −0.49 −0.67−0.54 −2.58 0.31 0.21 0.68 100240728 −0.61 −1.48 −1.29 0.18 −0.53 −1.28−1.80 −0.35 −1.66 1.60 −1.14 −0.16 26229 −0.81 −2.19 −1.42 −0.62 −0.44−1.67 −1.24 −0.10 −1.09 1.04 −0.35 −0.10 950 −0.51 0.23 −1.23 −0.64−0.61 0.58 −1.21 −0.71 −1.21 −0.52 1.47 −0.41 161882 −0.40 −0.48 −1.15−1.45 −1.12 −0.53 −0.79 −1.05 −1.85 1.20 −0.43 −0.39 5034 0.03 −0.90−1.26 −0.72 −1.37 −1.06 −2.03 −0.52 −1.36 0.68 0.97 −0.45 123355 −0.11−1.46 −0.65 −1.18 0.74 −0.82 −0.18 −0.86 −0.79 0.71 0.54 0.02 6734 −0.46−1.37 −0.59 −0.55 −1.25 −0.25 −0.54 −0.25 −0.02 −0.30 0.10 0.54 9911−0.50 0.14 −0.95 −1.31 −0.60 −1.53 −1.37 −0.86 0.64 −0.61 −0.20 −0.91222642 −0.73 −0.25 0.39 −0.95 −1.52 −1.68 −0.71 −0.93 0.44 −1.02 −1.00−1.54 3643 −0.40 −0.21 −1.22 −0.76 −1.70 −1.17 0.68 −0.88 −0.92 1.24−0.15 −0.62 85462 −0.81 −0.67 0.75 0.12 −0.65 0.05 −1.41 −1.02 0.54−0.51 −0.90 −0.39 149175 −1.02 −0.86 −0.89 0.07 0.22 −1.72 −1.95 −0.40−1.95 0.41 −0.35 −0.10 1819 −0.59 −2.41 −0.72 −0.95 0.00 −0.78 −1.19−0.94 −1.34 −0.10 0.60 −0.48 10370 −0.62 −1.04 −0.27 0.09 −1.87 −0.74−0.30 −1.07 0.04 0.42 0.80 −0.26 25792 −0.05 −1.30 −0.78 −0.73 −1.09−1.18 −0.71 −0.53 −0.61 0.86 0.57 −0.14 4072 0.35 −1.47 −1.29 −0.52−0.06 −0.55 −1.07 −0.51 −1.51 0.54 −0.64 −0.97 84447 −0.62 −0.51 −0.82−0.07 −0.69 −1.53 −0.53 −0.87 −0.63 1.35 −0.03 −0.26 527 −1.10 −0.710.26 −1.08 −1.38 −1.11 −1.26 −0.47 −1.00 0.53 1.03 −0.13 10629 −0.44−0.46 −1.55 −1.87 0.86 −1.13 −2.13 −1.10 −0.15 0.89 0.86 −0.60 511500.08 −0.87 −0.86 −0.98 −2.08 −1.07 −0.97 −0.52 −1.61 0.18 0.65 0.0157143 −0.99 0.37 −2.09 0.44 0.53 −2.14 −0.98 −1.30 −0.25 1.34 −0.33−0.70 682 0.61 −1.96 −0.72 −1.18 −0.56 −0.79 −1.33 −0.03 −0.85 −0.050.29 −1.11 10139 −0.03 −1.44 −0.88 −1.19 0.15 −0.10 −1.03 −1.09 −2.200.12 0.61 0.24 203238 −0.07 −1.31 −2.56 0.15 −0.77 −1.35 −0.24 0.80−1.81 0.39 0.47 −1.01 54805 −0.71 −0.19 −0.69 −0.53 −1.14 −0.89 −2.27−0.46 −1.16 0.42 −0.95 −0.04 1200 −0.27 −1.56 −0.55 −0.04 −0.17 −1.95−1.26 −0.68 0.97 −0.16 0.11 0.49 2271 −0.51 −0.72 −0.29 0.39 −0.72 0.11−2.07 −1.33 −2.12 −0.19 0.26 −0.53 376412 −0.30 −0.59 −1.49 −0.81 0.10−1.53 −1.99 −0.59 −1.49 1.02 0.36 0.28 4924 1.30 −2.44 −0.35 −0.63 −1.12−0.38 −1.00 0.02 −0.94 0.15 0.09 −0.41 55132 −0.14 −0.36 −0.74 −0.76−1.46 −1.45 −1.07 −1.06 −0.86 0.31 −0.92 −0.11 9650 −0.47 −2.56 −0.84−0.51 −0.78 −0.38 −1.17 −0.77 −0.31 −0.27 −0.58 −0.60 29803 −0.66 −0.23−1.24 −0.42 −0.37 −1.50 −1.76 −0.78 −1.36 1.43 0.63 0.34 4507 −1.34−0.25 −1.03 −0.78 −0.51 −1.08 −0.71 −1.44 −0.62 0.31 1.21 1.00 816 −0.92−1.72 −0.50 −2.28 −0.06 −1.48 −1.37 0.91 0.17 0.67 0.44 −0.01 1203790.42 0.09 −0.74 −2.12 −2.85 0.20 −1.88 −0.51 −0.61 0.50 −0.07 0.03 91289−0.77 0.02 −1.30 −0.42 0.39 −1.30 −1.02 −0.83 −2.28 0.92 −0.22 −0.6310905 −0.47 −1.17 0.50 −1.56 −1.18 −0.65 0.10 −0.93 −0.18 −0.28 0.54−0.14 25930 −0.03 −1.18 −0.27 0.57 −2.29 −2.08 −0.50 −0.90 0.10 0.690.20 0.71 57648 −0.14 −0.35 −0.88 −0.42 −0.20 0.17 −1.18 0.01 0.41 0.190.45 −0.22 7249 0.01 −2.52 −0.50 −0.69 −1.10 −0.75 −0.32 −0.30 −1.750.18 0.74 −0.06 55151 −0.17 −0.96 −0.14 −0.33 −1.17 0.40 −1.88 −0.70−0.12 −1.22 −0.12 0.04 160728 −2.74 −0.89 0.44 0.81 −1.06 −1.07 −0.70−0.41 −0.74 0.19 0.24 −0.70 148418 −0.47 −1.41 −0.78 −1.09 −0.57 −1.40−1.27 −1.02 −0.98 1.80 1.04 −1.05 646762 −0.50 0.05 −1.42 −0.18 −0.11−1.67 −1.88 −1.42 0.23 1.52 0.15 −0.80 79109 0.05 −0.62 −0.40 −0.58−1.97 −0.53 −0.98 0.65 −2.58 −0.26 0.40 0.20 81037 −0.56 0.12 −1.47−0.44 −0.95 −1.21 −1.68 −0.82 −1.86 0.99 0.53 −0.60 51523 −0.86 0.69−0.77 −0.96 −1.13 −1.08 −1.31 −1.02 −0.68 −0.33 0.23 −0.98 55322 −1.19−1.92 −0.84 −0.43 0.08 −0.06 −1.94 −0.30 −0.46 0.04 0.66 1.47 1009966710.83 −2.37 −0.81 −2.13 −0.74 −1.37 −0.90 0.07 −0.24 0.59 −0.06 −0.8355222 −0.15 −0.38 −2.38 −1.07 0.40 −0.33 −1.72 −0.20 −1.69 −0.75 0.47−1.05 55624 0.05 −0.95 −2.00 −0.16 −1.30 −1.25 −1.45 −0.62 −1.24 0.380.43 0.58 100505983 −0.22 −1.36 −0.31 −0.14 0.80 −0.64 −0.81 −0.39 0.10−1.00 −0.77 −1.21 3069 0.20 −0.05 −1.09 −0.89 −0.54 −1.77 −1.65 −0.48−1.57 1.64 −0.17 −0.39 10959 −0.45 −1.37 −0.78 −0.66 −1.67 −0.30 −1.87−0.27 −1.19 0.35 1.51 0.14 6598 0.23 −1.33 −1.85 −0.82 −0.83 −1.68 −0.75−0.49 −0.64 1.09 0.22 −1.02 60412 0.09 −0.82 −1.06 −0.22 1.00 0.34 −2.64−0.77 −0.34 −0.03 0.34 −0.47 54982 −1.13 −0.14 −0.97 −0.85 −0.43 −0.81−1.53 0.19 −2.33 0.61 0.38 −0.88 91752 −0.74 −0.90 −0.06 −0.82 0.39−1.31 −1.41 −1.05 0.19 −0.79 0.26 −1.36 113178 0.58 −2.16 0.01 −0.48−1.48 −0.91 −0.98 0.52 −1.27 0.00 0.41 −0.64 10 −2.02 −1.50 −0.51 −0.820.00 1.29 0.07 −0.19 −0.94 −0.06 0.31 0.49 375 −0.04 −1.44 −0.75 −0.71−0.31 −0.59 −1.57 0.25 −1.27 0.54 1.30 −1.11 5589 0.51 −0.95 −1.22 −0.60−0.45 −1.20 −1.19 0.19 −1.22 1.45 0.22 −0.09 9136 −1.22 −1.47 0.45 0.16−0.13 −0.18 −1.11 −0.12 −2.21 −1.46 −0.45 0.16 23193 −0.10 −1.18 −0.78−0.57 −1.28 −1.20 −2.09 −0.13 −0.77 0.29 1.21 −0.14 1798 0.23 −0.18−2.01 −0.74 −0.59 −1.17 −1.80 −0.78 −0.66 0.56 0.23 −0.25 85440 0.08−0.45 −1.70 −0.49 −1.37 −0.71 −1.44 −0.34 −0.15 −0.53 −0.03 0.71100505794 −1.64 −0.18 0.84 0.07 −0.81 −1.09 0.79 −0.19 −0.74 −0.81 0.69−0.41 1173 0.19 −0.83 −0.58 0.01 −1.24 −0.72 −1.26 −0.17 −1.41 0.52 0.410.49 124540 0.21 −0.60 −1.31 −0.30 −1.63 −1.61 −1.18 −0.02 −1.23 0.490.32 0.17 8372 −0.55 −0.71 −2.60 −0.63 −0.10 −1.86 −0.78 0.12 1.45 −0.18−1.76 −0.41 64755 −0.56 −0.55 −1.42 −0.35 −0.24 −1.81 −1.76 −0.68 −1.660.41 0.59 −0.48 79102 0.30 −1.43 −0.70 −1.38 0.39 −1.46 −2.44 −0.21−1.16 1.19 0.28 −0.77 10963 0.04 −2.09 −0.40 −0.42 −0.73 −0.21 −1.470.49 −1.67 −0.12 1.24 −0.17 375387 −0.66 −0.87 −0.01 −0.17 −0.11 −1.28−0.50 −0.60 0.24 −1.54 −0.83 −0.65 972 −0.16 −0.28 −1.43 −0.11 −0.01−0.70 −1.47 −0.12 −0.90 0.20 0.38 −0.74 54676 −0.84 −2.43 −0.14 −0.940.04 −1.20 −1.73 −0.38 −1.14 −0.52 −0.67 0.09 192286 −1.21 −0.95 −1.64−0.10 −0.35 −0.96 −1.57 −0.62 −0.45 −0.12 −0.06 0.30 3295 0.23 −0.96−1.28 −0.07 −1.22 −0.35 −1.62 −0.12 −0.33 −0.44 0.74 0.28 80852 −2.480.46 −0.23 −1.00 −0.28 −0.56 −1.60 0.29 −0.25 0.99 −0.45 0.32 1298 −0.09−1.17 −1.30 0.06 −0.27 −1.24 0.45 0.11 −2.40 1.06 −0.53 −0.79 2004 −0.621.45 −0.81 −0.93 −0.98 −0.84 −1.47 −1.45 −0.39 −2.20 −0.39 0.73 10279−2.85 −1.22 −0.19 −0.43 0.00 0.14 −0.38 −1.05 −0.19 −0.73 −1.41 0.10151790 0.21 −0.42 −0.58 0.23 −0.53 −0.55 −0.87 −0.58 −1.29 −0.51 −0.23−0.55 399664 −2.20 0.21 −0.20 −1.11 0.19 −0.11 −0.84 −1.00 −2.02 0.710.86 −0.53 5664 −0.49 −0.06 −0.67 −0.95 −1.10 −0.55 −0.82 −1.52 −0.69−0.48 0.70 −1.26 51614 −0.81 −0.96 −1.69 −1.06 −0.57 −0.66 −1.27 −0.86−1.00 1.10 0.44 −0.68 79178 −0.20 −0.91 −0.99 −0.52 −0.45 −0.70 −1.550.06 −2.35 0.14 0.23 −0.52 51726 −0.46 −0.02 −1.07 −0.56 −1.29 −1.52−1.64 −0.24 −2.37 0.98 0.57 −0.65 3425 −0.59 −0.24 −1.67 0.48 −1.44−1.45 −1.37 −1.23 −1.32 0.23 0.19 0.15 1642 −1.11 −0.14 −1.68 −0.30 0.04−1.21 −1.77 −1.06 −1.05 0.65 −0.11 −0.13 101928770 0.07 −2.41 0.42 −0.74−0.38 −1.28 1.03 −1.00 −0.24 0.14 −0.97 0.15 11015 0.13 −0.90 −1.05−1.01 −0.66 0.40 −1.50 −1.03 −1.40 0.20 1.30 −0.43 35 −0.31 −0.92 −1.80−1.34 −0.11 −1.72 −0.57 −0.59 −1.68 1.63 −0.30 0.76 64798 −0.04 0.17−1.91 −0.69 −1.41 −1.48 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−1.79 −0.04 −1.010.14 −1.22 −0.85 −2.07 −0.84 0.81 −0.31 10972 −0.89 −0.25 −0.98 −0.40−1.46 −0.19 −1.53 −0.52 −0.83 −0.04 0.35 0.62 23061 −0.61 0.36 −2.05−0.57 0.68 −1.81 −2.03 −0.54 −0.50 1.07 0.38 −0.24 3792 0.95 −0.63 −1.580.55 −0.34 −0.72 −0.74 −1.03 0.51 −1.59 −0.61 −0.82 2063 −0.45 −1.95−0.34 −0.82 −0.42 −0.19 −0.82 −0.99 −1.05 1.04 −0.08 −1.50 55177 −0.89−0.07 −2.03 −0.04 0.26 −0.51 −1.87 −1.07 −0.42 −0.46 0.51 −0.67 111470.21 −1.73 −0.67 −0.17 0.33 0.02 −1.46 −0.63 −0.49 −1.48 −0.53 −0.1557486 0.41 0.16 −0.80 −1.04 −0.54 −1.81 0.10 0.08 −0.39 −0.68 −0.02−0.44 30814 −0.20 −1.11 −1.25 −1.55 −0.09 0.17 −1.32 1.17 −1.13 1.760.08 0.07 57414 −0.68 −0.87 −0.95 −0.83 −0.40 −0.34 −1.04 −0.51 −1.611.09 1.76 −0.93 84836 −0.77 0.14 −1.42 −0.30 −0.83 −1.04 −1.21 −1.88−1.02 0.71 0.55 0.04 8516 0.93 −1.32 0.38 −1.48 0.19 −0.48 0.22 −1.34−0.59 −0.80 −0.71 −0.91 89866 −0.52 −1.19 −2.47 −0.47 −1.09 −1.23 −1.28−0.86 1.00 0.80 0.49 −0.17 10491 −1.46 1.30 −0.37 −0.39 −1.44 −1.15−0.34 −1.17 −0.38 0.86 0.22 0.63 11047 −0.35 −1.14 −1.04 −0.78 1.01−1.44 −1.42 −0.65 −1.92 0.73 0.22 −0.91 28971 0.87 0.17 −2.19 −0.58 0.06−1.82 −1.72 −1.03 −1.00 1.01 0.39 −0.43 8078 −0.68 −0.66 −1.54 −0.640.06 −1.61 −0.79 −0.05 0.00 0.26 0.29 0.46 37 0.27 −0.90 −1.46 −0.37−0.18 −1.67 −1.00 −0.69 −2.44 0.71 0.40 −0.81 145508 −2.43 0.86 −0.27−0.22 −1.14 −0.22 −0.88 −1.73 0.49 −0.87 0.38 −0.08 49861 −1.79 −1.45−1.00 −0.62 −0.48 0.21 −0.66 −0.44 0.45 1.92 0.48 −0.68 5905 −0.26 −0.19−1.82 −0.41 −0.21 −1.01 −1.46 −0.07 −2.74 0.95 −0.20 −0.18 7542 0.40−1.75 0.16 −0.45 −0.49 −0.71 −0.43 −0.82 −2.69 −0.62 1.20 −0.85 9562−1.41 −1.06 −0.10 0.68 −1.68 0.34 −0.44 −0.28 −0.58 −1.52 −0.25 0.1879095 −0.54 −1.81 −1.41 −0.33 0.96 −0.80 −0.84 −0.51 −1.63 0.97 0.93−0.10 8815 0.62 −1.77 −0.92 −0.97 −0.73 −0.13 −1.25 0.19 −0.20 −0.050.57 0.37 54867 −0.26 −1.31 −1.25 −0.40 −2.00 −0.89 −0.75 −0.56 0.611.97 −0.05 0.68 6721 −0.41 −0.84 −1.28 −0.71 −0.20 −1.67 −0.98 0.44−1.03 1.08 1.63 −1.16 23133 −1.80 0.31 −0.51 −1.00 −0.42 −1.45 −0.75−0.02 −0.49 1.72 −0.57 0.70 113675 −0.08 −0.65 −0.86 −0.59 −0.23 0.05−1.80 −0.22 −1.55 −0.74 −0.31 −0.39 129303 0.63 −0.87 −1.14 −0.18 −1.12−2.01 −2.22 −1.38 0.92 −0.08 0.79 0.77 57658 −1.31 −0.60 −0.22 −0.57−0.06 −1.37 −1.12 −0.15 0.04 2.19 0.40 0.59 162 −0.01 −0.65 −1.04 −0.460.39 −1.24 −0.53 −0.45 −2.53 0.87 0.24 −1.00 2873 0.19 −0.64 −1.89 −0.460.03 −1.64 −1.37 −0.52 −1.98 −0.63 0.97 −0.55 64978 0.51 −2.16 −0.49−0.44 0.02 −0.43 −1.89 −0.71 −1.57 −0.49 1.44 0.29 220323 0.05 −0.21−1.96 −1.16 −1.10 −1.46 −0.88 −0.76 −0.15 0.57 −0.16 −0.45 6006 −0.210.44 −0.98 −0.96 0.11 −0.35 −0.32 −2.07 1.25 −0.63 −1.58 −0.47 389812−0.97 −1.86 −0.92 −0.47 0.18 −1.89 −1.46 0.51 −0.27 0.30 −0.11 0.54 2628−0.51 −0.24 −0.77 −0.41 −0.50 0.76 −1.29 −0.12 −0.63 −0.91 0.26 −0.806509 0.40 0.52 −0.81 −0.96 −0.62 −0.94 −1.58 −1.54 −0.58 0.41 0.35 −1.263888 −0.62 −0.26 −1.61 −1.47 −0.07 −2.05 −0.47 −0.53 −0.82 2.32 0.46−0.22 5211 −1.00 0.14 −1.54 −0.58 0.42 −1.76 −1.34 −0.31 −1.71 1.16 0.16−0.38 55080 −1.01 −0.64 0.06 −0.50 0.32 −0.05 −0.43 −1.30 −1.03 −0.220.34 1.22 2139 0.41 −1.52 −1.27 −0.08 0.94 0.72 −1.22 −1.55 −0.82 −0.31−0.73 −0.04 2030 0.08 −1.26 −1.36 −0.97 −0.26 −1.64 −0.75 −0.98 −0.28−0.02 0.19 −1.69 56005 −0.18 0.35 −1.40 −0.24 −0.71 −0.49 −1.30 −0.95−1.94 0.46 0.86 −0.87 6414 0.86 −1.04 −1.09 −0.68 −1.59 −0.49 −0.89−0.68 0.14 −1.32 0.19 −0.45 5184 −0.28 0.05 −0.97 −0.12 −0.53 −0.49−0.93 −0.41 −0.92 0.78 0.21 0.29 643783 −0.30 −0.73 −0.39 −1.05 −0.580.11 −0.85 −2.07 −0.01 −0.15 −0.59 −0.69 101928185 −0.15 −1.37 −0.63−0.59 −1.98 0.77 −0.44 −1.62 1.00 −0.18 2.19 −0.74 22883 −0.04 0.08−1.78 0.15 −0.12 −1.13 −1.16 −1.23 −0.93 1.48 0.62 0.54 25800 0.19 −1.18−1.06 −0.44 −2.67 −0.39 −0.57 −0.39 −1.73 0.50 0.69 −0.05 54681 −0.26−0.49 −2.25 −0.14 −0.71 −0.87 −1.45 −1.29 −1.09 0.79 0.73 0.36 644150−0.20 −1.36 −0.25 −1.42 −1.20 0.56 −1.50 0.02 −0.58 0.38 1.10 −0.66 9048−0.02 −0.51 −1.44 −0.70 −1.11 −1.39 −0.58 −0.96 0.03 1.54 −0.41 −0.203054 0.29 −0.46 −1.57 −0.46 −0.74 −1.34 −2.37 −1.10 −1.16 1.18 0.15−0.53 115098 −0.23 −1.33 −0.65 −0.49 −0.36 0.11 −0.91 −0.95 −1.73 0.73−0.10 −0.74 55558 −0.16 −0.98 −1.98 −0.76 −0.43 −1.30 −1.51 −0.78 −0.450.20 0.59 0.09 675 0.83 −0.67 −0.79 −0.77 −1.18 −1.71 −0.78 −1.13 −1.61−0.06 −0.15 −1.28 9777 −0.22 −0.71 −0.94 −0.60 −1.42 −1.36 −0.78 −0.99−1.21 −0.17 0.44 −0.12 83707 0.66 −0.32 −0.96 0.26 −1.13 −0.12 −1.86−1.51 −1.91 0.78 0.09 0.07 55334 0.10 −1.24 0.02 −0.97 0.16 −0.36 −2.120.21 −0.09 0.21 0.56 −0.75 9793 −0.58 −0.79 −2.20 −0.63 −0.99 −1.59−1.83 −1.05 −0.61 0.33 0.21 0.14 56834 −0.16 −1.80 −0.65 −0.91 1.33−1.08 −1.71 −0.58 −0.68 −0.32 1.03 −1.49 25921 0.18 −0.80 −1.37 −0.94−0.61 −1.61 −1.67 0.08 −2.40 0.82 1.06 −0.75 6520 −0.52 −1.00 −1.42−0.24 −0.20 −1.68 −1.78 −0.18 −0.41 0.14 0.70 −0.34 728591 −0.25 −2.19−1.03 −0.77 −0.31 −2.56 −0.93 0.44 −0.52 1.26 0.29 0.26 7415 0.52 −0.15−1.24 −0.38 −0.49 −1.55 −1.45 −0.43 −2.29 1.44 0.18 −1.31 130827 0.22−0.27 −1.98 0.13 −1.18 0.68 −2.05 −1.40 −0.24 −0.42 0.11 −0.11 9620−0.16 −1.36 −1.62 −0.97 −1.27 0.61 0.57 −0.53 −0.17 −0.14 0.46 −0.1955335 −1.05 −1.02 −0.39 −0.77 −0.14 −1.00 −0.52 −1.05 0.17 0.33 −0.47−0.28 84988 0.96 −0.89 −1.50 0.07 −0.98 −0.32 −1.33 0.34 −1.48 −2.091.44 −0.70 100192378 −0.08 −0.77 −0.53 −0.89 0.11 −1.09 −1.44 0.41 1.80−0.16 0.04 −0.76 442524 −1.03 −1.65 −0.06 0.00 −1.42 −0.34 −0.81 0.061.36 −0.63 −0.05 −0.84 51661 0.68 −0.53 −2.05 −0.71 0.13 −2.12 −1.11−0.33 −0.66 0.39 0.71 −0.07 84922 −0.63 −1.48 −0.47 0.27 −1.56 −0.92−1.93 −0.11 −1.40 0.08 1.24 0.55 84954 0.67 −0.29 −0.31 −1.39 −0.88−0.83 −0.64 −0.60 −1.29 0.77 0.85 −0.79 245972 −1.17 −0.90 −1.01 −0.541.67 0.72 −0.73 −1.14 −1.10 2.12 −0.40 −0.49 4316 −0.85 −0.80 −0.12−1.04 0.22 −0.85 −1.80 0.25 −0.51 1.17 −0.52 −1.12 55157 −0.11 −1.26−0.46 −1.05 −0.51 −1.34 −1.89 −0.78 0.46 −0.81 −1.38 0.79 7466 −1.00−0.86 −1.74 0.06 0.43 0.75 −0.51 −0.61 −0.56 0.08 0.30 −1.23 79365 −1.16−0.08 0.05 −0.90 −0.83 −0.38 −0.80 −0.68 0.48 −0.30 −0.18 −1.83 10066−0.95 −0.61 −1.47 −0.69 1.05 −1.45 −1.85 −0.43 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2.63 1.24 −1.14 0.73 0.72 −1.120.69 0.95 54557 0.17 0.59 2.07 0.35 −0.05 1.50 1.79 0.93 0.64 −0.54−0.02 0.72 56267 0.59 0.68 1.12 0.66 0.00 1.40 0.55 0.51 −1.04 −0.31−1.27 2.06 51176 −1.07 0.94 0.73 1.19 0.97 1.09 1.34 −0.10 1.68 −0.170.40 1.23 10468 0.77 0.69 0.48 0.50 0.02 0.92 0.94 1.12 −1.83 −0.50 1.95−1.06 23258 0.68 0.33 2.08 0.61 0.09 0.54 1.76 1.08 0.95 −0.33 0.11 0.4490768 0.45 0.94 0.64 0.78 1.61 1.01 0.49 0.60 1.84 −1.64 −1.32 −0.38134957 0.98 −0.56 2.12 0.46 −0.53 0.73 1.82 0.91 1.02 −0.17 −0.11 0.4480342 −0.81 1.33 0.34 0.89 0.53 0.13 0.34 0.28 1.29 0.80 −0.40 1.9391351 0.33 0.10 1.95 0.83 0.14 1.02 1.47 0.92 1.37 −0.12 0.11 0.83 299160.79 −0.08 1.78 0.79 0.64 0.74 1.63 1.25 −0.33 −0.90 −0.74 −0.48 8519−1.06 0.89 1.30 0.22 1.44 1.02 0.77 0.61 1.56 −0.27 0.36 0.81 2113 −0.932.02 0.13 0.53 1.00 0.61 0.39 0.46 1.48 0.16 0.65 1.32 55770 −0.31 0.600.06 0.36 0.01 0.40 1.04 −0.23 0.99 0.29 0.76 1.44 91833 0.30 0.45 2.250.37 −0.15 1.37 1.26 0.24 0.42 −0.54 0.23 0.99 117177 0.40 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0.42 1.64 0.341.17 1.26 2.19 1.17 1.24 −1.01 −0.53 0.44 51455 −0.17 0.25 1.09 1.24−0.48 0.99 0.97 0.45 1.46 −0.58 0.15 1.21 1178 0.09 0.20 1.78 0.51 −0.130.64 1.87 0.98 2.19 −0.60 0.32 −0.25 79153 0.18 −0.58 1.62 0.72 1.270.78 1.50 0.97 1.38 −0.35 −0.30 0.47 101928524 0.40 0.08 1.77 1.16 −0.460.73 0.94 1.31 1.31 −0.02 −0.31 0.93 11064 1.20 0.12 −0.51 1.36 1.590.01 −0.03 0.05 0.79 1.94 0.51 0.43 23429 0.34 0.90 1.15 0.20 −1.70 0.211.99 1.03 0.49 0.29 0.20 0.01 5170 0.56 0.68 1.76 0.38 0.14 0.81 2.130.73 1.11 0.69 −0.52 0.06 10677 −0.08 0.35 1.90 0.81 0.36 1.44 1.66 0.830.69 0.22 0.20 0.19 3772 0.28 0.14 2.03 0.52 0.51 1.10 1.60 0.82 1.35−0.24 0.07 −0.32 128061 −0.79 0.76 1.14 1.31 1.07 0.65 2.07 0.85 1.41−0.41 −0.93 1.16 50856 0.35 1.13 1.69 0.48 −0.23 1.62 1.62 1.15 1.23−1.44 −0.54 0.24 6198 0.04 1.34 0.64 0.55 −3.33 0.42 0.38 1.20 0.40 0.29−0.61 0.63 101927588 1.52 1.05 1.26 0.45 2.73 0.04 −0.27 −0.20 1.03−1.19 0.20 −0.19 2000 0.01 1.08 2.17 0.66 −0.34 0.03 1.33 0.91 1.07−0.17 −0.57 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1.17 −1.21 −0.51 0.45 7846 0.66 1.03 0.560.63 0.04 0.74 0.87 0.79 0.77 0.19 −0.39 −0.33 100652740 0.08 0.30 0.971.47 0.59 0.24 0.29 0.92 1.69 0.07 −0.62 −0.89 23398 0.73 0.21 0.44 1.35−1.17 0.10 0.47 0.70 0.67 0.97 −0.42 2.08 158747 0.26 −0.04 2.04 0.630.13 1.51 1.61 1.18 1.23 −0.74 0.10 0.42 285512 0.11 0.28 1.69 0.75 0.260.30 2.21 0.39 1.10 −0.19 −0.46 0.95 3937 −0.27 0.84 0.90 0.75 −0.130.47 0.49 0.50 1.43 −0.03 0.81 1.85 730051 0.68 1.09 1.57 0.62 −0.82−0.93 0.66 0.22 1.04 0.32 −0.14 1.42 9320 −0.17 1.55 1.08 0.07 −2.000.47 0.79 0.86 0.14 0.43 0.46 0.76 6932 −1.09 1.37 0.50 0.73 0.44 1.170.61 0.47 1.06 0.39 0.39 1.63 79722 −0.41 0.88 1.17 0.74 0.27 1.50 1.300.56 1.77 −0.89 0.27 0.12 115362 −0.29 1.49 −0.02 1.26 1.46 1.19 0.55−0.05 1.99 −0.51 0.69 1.24 29909 −0.56 0.88 1.28 0.65 0.90 1.66 0.880.47 1.80 −1.36 0.24 1.33 440503 0.83 0.33 2.05 0.14 0.45 0.59 0.93 1.690.32 1.11 −0.18 −0.34 80183 0.26 0.27 1.91 0.48 0.38 1.01 1.58 1.33 1.23−0.22 −0.40 −0.76 80709 −0.21 0.67 0.92 0.61 0.58 0.59 1.01 0.60 1.040.99 0.16 1.28 10562 0.89 −0.39 2.05 0.92 0.49 0.72 1.00 1.20 1.78 −1.100.02 −0.06 64780 1.48 0.26 0.63 1.04 −0.26 −0.09 2.00 1.38 0.06 1.250.02 −0.14 155038 −1.06 1.56 1.12 0.57 0.95 1.41 1.01 0.72 0.50 −0.210.33 1.28 1783 0.93 0.38 1.95 0.70 −1.11 1.71 1.64 0.68 −0.45 −0.12 0.680.07 100287569 0.39 0.32 1.40 0.59 0.71 −0.45 1.00 1.34 0.79 −0.50 −0.350.59 5696 0.44 1.12 0.03 1.78 0.93 0.89 −0.08 0.22 −2.47 −0.20 0.67 0.0311066 1.09 −0.04 1.16 0.44 1.21 0.14 0.91 1.70 1.01 0.41 0.62 −0.32122553 0.36 −0.63 1.39 0.56 −0.93 0.77 0.80 1.42 0.31 0.49 −0.09 1.3750484 0.71 0.41 2.16 0.69 −0.45 1.31 1.81 1.13 −0.29 −0.26 0.13 0.179847 0.18 0.82 1.07 1.59 0.11 1.41 0.76 0.81 0.31 −0.69 0.01 1.15 1292850.41 −0.58 1.41 0.55 0.54 0.61 0.82 0.98 0.85 0.04 0.54 2.65 9794 −0.210.86 2.10 0.43 0.18 0.45 1.39 1.23 0.21 0.26 −0.07 1.37 84309 1.06 1.080.92 1.33 −1.60 0.08 1.20 −0.35 −0.09 0.78 −0.73 0.06 65258 0.10 0.912.01 0.10 −1.04 1.16 2.05 0.81 0.84 −0.12 −0.49 0.44 5562 0.85 −0.312.07 0.30 −0.88 0.95 1.03 0.81 1.47 0.02 0.12 1.35 123036 −1.10 1.320.58 0.73 0.34 1.88 0.62 0.25 1.61 −1.02 0.44 1.77 84166 0.03 1.45 0.081.27 1.65 −0.26 0.73 0.73 1.25 0.76 0.07 0.89 253143 0.16 0.30 1.74 1.331.03 0.73 1.99 0.97 0.09 −0.11 0.01 −0.40 1236 −0.91 1.10 −0.17 0.591.24 0.65 0.70 0.96 1.18 −0.18 0.29 1.06 266747 0.35 0.48 1.77 0.88 0.420.75 1.35 0.73 1.32 −0.25 −0.07 0.66 25988 −0.63 0.89 0.80 1.02 −0.370.31 0.61 0.39 0.38 0.39 0.75 0.64 6515 0.47 0.65 1.85 0.11 −0.06 0.411.51 1.55 1.39 −0.40 −0.12 −0.35 90592 1.21 −0.05 1.09 1.02 0.46 0.731.68 1.49 −0.92 0.64 −0.39 1.35 6867 0.49 0.94 2.45 0.30 −0.47 0.69 1.840.32 0.56 −0.40 −1.37 −0.74 23041 0.77 −1.09 0.76 0.48 −0.39 0.74 1.890.63 1.64 −0.08 0.66 1.60 100289230 0.17 0.81 1.13 0.29 −1.19 1.80 1.950.86 0.19 −2.01 0.16 0.13 57169 0.09 0.55 1.50 0.33 0.83 1.63 1.61 0.131.45 −0.63 0.03 0.98 1105 0.72 0.97 1.24 0.49 −1.30 0.11 1.55 0.86 0.95−0.32 0.12 0.77 943 0.47 0.19 1.34 0.36 1.00 0.25 1.11 2.05 −0.21 −0.350.17 −1.44 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0.70 0.64 0.06 0.58 120425 0.50 0.771.52 0.76 0.58 1.25 1.31 1.33 0.85 −0.58 −0.15 0.79 6840 0.29 0.86 1.200.59 0.19 0.74 1.52 0.40 1.72 −0.21 0.39 0.62 26268 0.19 1.31 1.98 1.07−0.61 1.10 1.08 −0.30 1.30 −0.88 0.14 0.52 55206 0.30 0.70 2.42 0.60−0.30 0.70 2.19 0.42 0.46 0.47 −0.23 0.26 355 0.75 −0.19 1.88 0.04 0.152.14 1.10 0.82 1.07 −1.25 −0.22 0.34 50615 −0.81 1.49 1.00 0.22 0.901.16 0.94 0.97 0.88 −1.86 0.04 −0.03 221178 0.40 1.14 1.04 0.40 0.981.33 0.19 1.08 1.15 0.26 0.44 1.42 11104 0.15 −0.35 1.56 1.05 1.98 0.361.03 1.12 −0.19 0.52 −1.14 0.36 1117 −0.94 1.73 0.09 0.77 1.18 2.05−0.83 1.49 −0.09 0.11 0.27 0.61 374969 0.52 0.95 1.62 0.39 0.72 1.641.69 0.74 0.50 −0.87 −0.15 0.19 6285 0.66 1.66 0.22 −0.29 0.23 0.47 2.40−0.14 1.60 0.08 −0.53 0.23 387357 −0.25 0.42 0.58 0.88 0.38 1.49 1.050.38 1.75 −0.66 0.32 2.20 2960 0.46 0.05 1.75 0.60 0.45 1.98 1.10 0.630.93 −0.86 0.37 0.93 100129550 0.40 0.98 2.25 0.42 −0.51 0.93 1.92 0.540.95 0.15 −0.23 −0.07 54520 0.56 1.00 1.95 0.57 0.20 0.83 1.02 0.45 1.010.46 −0.36 0.04 10302 0.47 1.39 0.92 0.94 2.08 1.20 0.86 −0.13 0.27−0.68 −0.41 1.09 50939 0.25 0.88 1.11 1.52 0.97 −0.52 0.34 −0.48 0.700.57 −1.29 −0.37 8802 0.65 0.50 1.05 1.24 −2.63 1.10 0.94 0.44 −0.40−0.45 0.01 −0.50 23332 0.71 0.25 1.48 1.22 −0.75 0.32 1.97 0.41 −1.34−0.45 0.38 0.22 203328 −0.31 0.84 0.94 0.92 0.73 1.34 1.12 0.86 0.63−1.00 −0.47 0.74 126231 −0.25 2.14 0.29 1.06 0.34 0.75 1.21 −0.48 0.660.36 0.13 1.63 6993 0.82 0.55 1.52 −0.09 0.35 2.13 1.40 0.11 1.40 −0.550.33 0.40 58500 1.21 1.15 2.33 0.54 −0.27 0.72 0.78 0.11 −0.64 0.90−0.60 0.86 10507 −0.04 1.02 1.83 0.47 0.44 0.19 1.52 0.86 0.83 0.35 0.010.98 170482 0.78 1.64 0.77 0.99 −0.35 2.06 0.48 0.57 2.67 −0.61 −0.90−0.37 3004 −1.17 0.69 −0.20 1.10 1.03 1.29 −0.34 0.50 0.91 0.71 1.021.57 64895 −0.61 0.09 1.82 0.86 0.06 1.01 1.49 1.11 0.78 0.00 −0.08 0.877850 0.37 0.31 1.82 0.25 0.17 0.98 1.74 1.34 0.74 −0.71 −0.03 −0.5893594 −0.83 1.85 −0.23 1.06 0.91 0.06 1.25 0.46 1.95 0.16 −0.09 1.9623215 0.21 1.43 0.54 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−0.42 0.93 1.19 0.64 1.81 0.581.19 0.26 −1.08 0.38 0.71 0.90 253018 −0.40 0.37 1.54 0.33 0.70 1.542.03 0.29 1.51 0.00 −0.62 0.35 10096 −0.18 0.65 1.15 1.29 −0.25 0.380.69 1.65 1.38 −0.20 −0.45 0.82 84138 −0.11 1.94 0.71 0.61 0.92 1.420.62 0.53 −0.60 −0.02 −1.03 0.89 8440 −1.44 1.15 0.75 0.32 1.35 0.511.57 0.37 1.51 0.32 −0.17 1.03 7277 −0.14 0.59 1.42 0.67 1.32 0.97 0.980.59 1.01 −0.39 −0.49 0.50 8269 0.72 0.93 1.95 0.42 0.54 1.96 −0.12 0.60−0.65 −0.21 0.84 0.28 8807 −0.16 0.55 1.98 0.82 0.56 0.78 1.65 1.12 1.70−0.51 −0.05 0.59 1235 −0.68 1.67 1.50 0.33 0.37 1.55 0.12 −0.25 0.85−0.46 −0.84 0.85 7059 1.95 0.89 1.47 −0.02 1.14 −0.06 −0.22 0.71 −0.720.00 0.33 −0.07 54971 −0.42 1.75 2.08 0.38 0.58 0.76 1.60 0.63 0.70 0.64−0.99 −0.06 57677 1.02 0.18 0.05 0.35 −0.01 0.40 2.20 0.17 0.56 0.74−0.57 0.90 6890 0.39 0.26 0.79 0.72 0.98 1.34 1.71 0.64 0.63 −1.03 −0.170.66 22944 0.09 −0.32 1.94 0.73 0.00 1.44 1.28 1.19 1.12 −0.05 −0.181.23 26512 0.00 0.49 1.72 0.26 −0.96 1.66 1.82 1.78 0.92 0.02 −0.55 1.0692797 1.09 −0.03 1.19 1.08 −0.37 0.13 1.17 1.27 2.08 0.29 0.15 0.28 54810.38 −0.13 1.29 0.80 −0.54 1.49 0.89 1.07 −0.15 −0.44 −0.16 1.25 228970.20 1.63 −0.43 0.51 3.52 0.05 0.28 0.09 0.02 1.28 −0.28 1.15 3620 −0.360.77 1.28 0.63 0.56 1.92 1.06 0.66 1.37 −1.58 0.08 0.03 64766 0.93 0.830.37 1.77 0.42 −0.57 0.49 1.17 0.48 1.12 −0.57 1.49 8809 0.39 0.19 1.610.57 0.17 1.19 1.66 1.13 1.69 −0.60 0.21 0.52 116984 −0.12 1.32 0.971.27 1.02 0.99 1.41 1.06 1.03 −1.31 −0.37 1.42 440823 −0.05 0.90 0.560.24 0.70 0.92 −0.15 1.56 1.36 0.18 0.96 0.39 59340 −0.36 −0.17 1.400.32 1.80 0.61 1.00 1.12 1.55 0.73 0.56 0.03 197259 −0.41 0.04 2.12 0.831.57 1.26 0.65 0.65 1.09 −0.49 −0.28 1.28 23670 0.25 0.73 1.86 0.32 0.661.42 1.25 0.79 1.14 −0.51 0.44 0.65 643314 1.32 0.38 0.60 0.37 −0.320.79 1.39 1.01 0.50 0.14 0.09 0.93 28526 −0.85 1.74 0.35 1.07 0.55 0.930.70 −0.11 1.52 0.75 −0.26 1.46 55096 0.85 1.02 1.94 0.13 −0.08 1.221.64 0.56 0.61 −0.58 −0.16 0.11 2796 −0.16 0.76 0.78 0.24 1.70 0.70 0.460.48 −0.44 0.63 0.13 1.22 54509 −0.18 1.61 0.96 0.22 0.15 0.33 −0.361.34 0.29 −1.91 −0.14 −0.07 11120 −1.10 0.74 1.59 1.22 1.25 0.54 1.620.07 0.36 0.70 0.07 0.37 84869 0.50 0.27 0.41 1.51 0.07 1.46 1.79 1.910.17 0.75 −0.61 0.70 28991 0.04 0.57 2.23 0.61 0.06 1.64 1.49 0.50 −0.44−0.56 −0.06 0.31 154141 1.28 −0.32 1.71 0.48 0.68 0.97 1.43 0.93 0.110.16 0.55 −0.53 3659 0.46 0.85 1.63 0.44 0.41 0.87 2.23 −0.13 1.69 −0.78−0.51 0.22 154007 0.84 −0.19 1.65 0.32 0.02 0.39 1.85 1.53 1.44 −0.29−0.70 0.17 116835 0.79 0.78 −0.15 −0.17 2.37 0.99 0.77 0.54 1.12 0.120.26 −0.34 9488 0.43 0.80 1.28 0.77 1.28 −0.25 2.06 0.67 −0.14 0.41−0.12 0.82 100293516 1.59 0.62 0.76 1.92 0.19 0.23 1.07 0.75 0.57 1.62−0.80 1.85 9217 0.05 1.47 1.18 0.82 0.73 1.49 1.54 −0.05 0.49 0.58 −0.070.14 10538 1.05 −0.09 0.04 1.11 0.93 1.13 1.13 1.29 −0.07 0.25 −0.270.46 6935 0.62 0.40 0.57 0.10 −0.09 0.26 1.22 1.16 0.67 0.42 0.47 0.3810443 0.19 0.33 0.96 1.05 0.11 0.71 1.52 0.69 0.92 −0.06 0.56 1.76 3837−0.05 1.52 1.10 1.48 0.98 0.29 0.83 1.02 0.88 0.28 0.41 0.01 81698 0.580.50 1.27 −0.17 1.15 1.10 1.20 0.94 −0.19 −0.26 0.57 −0.32 2643 0.500.99 1.44 −0.26 0.30 0.89 0.61 −0.21 1.51 −2.32 −0.02 1.22 57559 −0.871.17 0.28 0.80 1.87 1.24 0.52 0.84 0.96 −0.53 −0.33 1.18 116842 −0.181.22 1.47 1.24 −0.34 1.56 0.50 0.64 1.46 −0.72 −0.53 1.59 202 0.01 1.521.00 0.75 0.90 0.73 0.66 0.40 1.37 0.03 −0.21 1.09 9934 0.14 0.61 1.540.87 0.14 1.44 2.04 0.82 0.82 −1.17 0.24 0.64 100216546 0.72 0.98 1.370.09 −0.33 1.60 1.27 1.30 1.61 −0.28 −0.58 0.24 9692 0.30 1.02 0.38−0.56 2.06 0.68 0.52 1.27 0.32 0.38 −0.74 0.68 89845 0.22 1.66 0.08 1.441.47 0.53 0.21 1.07 −0.51 0.40 −0.76 1.25 26034 −0.60 1.24 1.25 0.801.40 1.07 1.25 0.92 1.34 −0.11 −0.16 1.08 10906 0.29 0.91 1.62 0.23 1.861.01 1.12 1.38 0.13 0.05 0.27 −0.50 84811 0.33 0.74 1.40 1.66 0.12 −0.131.56 1.04 0.52 0.12 −0.11 0.46 100527964 0.70 0.47 0.30 1.34 0.37 −0.34−0.21 1.15 0.84 1.60 −0.37 1.50 118426 0.15 1.01 0.95 0.81 0.19 1.801.21 1.04 1.61 −0.72 0.09 0.21 54331 −0.04 0.27 1.33 0.71 0.62 0.50 1.621.42 1.14 0.13 0.26 0.49 94081 0.60 0.43 1.31 1.26 −0.58 1.19 0.68 1.330.42 −0.71 0.21 0.72 145474 0.87 1.04 1.28 0.06 0.15 1.37 2.52 1.11 1.12−0.57 −0.27 0.00 84969 0.74 0.73 0.71 0.64 0.33 1.83 1.20 0.92 0.57−0.79 −0.46 −0.03 4907 −0.61 2.13 0.02 0.50 −0.38 0.88 0.65 −0.17 1.471.62 0.16 0.74 51735 −0.04 1.08 1.90 0.65 −0.13 1.37 1.58 0.38 1.25−0.35 −0.08 0.48 9953 0.36 1.18 1.23 1.47 0.26 0.98 1.12 0.86 0.96 −0.190.40 1.56 23112 −0.24 1.51 1.77 0.55 0.67 1.02 1.48 0.19 0.40 1.01 0.230.65 91526 0.18 0.97 1.90 1.07 0.55 1.12 0.46 1.14 0.65 −0.09 −0.04 1.26101928017 −0.17 1.87 0.03 0.21 0.43 1.92 0.24 0.61 0.89 −0.88 −0.07−0.43 84859 −0.48 0.28 1.08 1.43 1.70 0.97 0.72 0.52 0.21 0.59 0.52 1.69159013 −0.09 0.87 2.04 1.26 0.08 0.73 1.49 1.14 0.74 −0.06 −0.34 1.0623208 0.61 1.08 1.11 1.25 0.52 0.54 0.41 1.02 0.94 −1.17 −0.67 1.05101928649 1.25 −0.40 1.41 1.37 0.14 −0.38 1.40 1.81 −0.35 −0.41 −1.010.57 85459 0.76 0.54 1.00 0.69 −0.64 0.10 2.21 1.43 0.35 0.59 −0.59−0.20 9617 0.54 −0.11 0.92 1.44 0.33 0.80 1.02 0.78 0.74 −0.78 −0.532.48 56898 1.59 0.83 0.88 0.66 0.29 0.73 −0.24 1.14 0.11 0.60 −1.18 0.62387882 1.33 1.38 1.03 0.70 0.51 0.55 0.32 0.55 1.23 −0.65 −0.91 1.27677769 0.50 2.09 0.27 0.72 0.83 1.44 0.65 1.55 0.36 0.16 −0.28 −0.25

TABLE 3 gene symbol name fisherz 34 35 36 56904 SH3GLB2 SH3-domain 3.670.86 0.03 0.37 GRB2-like endophilin B2 6464 SHC1 SHC (Src 3.56 −0.43−1.06 −1.09 homology 2 domain containing) transforming protein 1 79087ALG12 ALG12, 3.45 1.14 −0.24 0.59 alpha-1,6- mannosyltransferase101928190 LOC101928190 uncharacterized 3.43 1.24 0.71 0.74 LOC1019281903416 IDE insulin- 3.17 0.76 0.80 −1.08 degrading enzyme 8001 GLRA3glycine 3.16 −0.21 1.30 0.32 receptor, alpha 3 3727 JUND jun D proto-3.13 0.20 −0.25 0.01 oncogene 10945 KDELR1 KDEL (Lys- 3.12 0.44 −0.09−0.61 Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 15025 P2RX4 purinergic 3.09 0.96 −0.42 0.15 receptor P2X, ligand-gatedion channel, 4 29920 PYCR2 pyrroline-5- 3.07 −0.04 0.00 0.49 carboxylatereductase family, member 2 101929248 LOC101929248 uncharacterized 3.010.19 −0.17 −0.18 LOC101929248 23646 PLD3 phospholipase 2.98 0.65 −0.640.06 D family, member 3 10280 SIGMAR1 sigma non- 2.97 0.22 0.01 0.14opioid intracellular receptor 1 140699 MROH8 maestro heat- 2.96 0.321.56 −0.41 like repeat family member 8 4669 NAGLU N- 2.94 0.38 −0.30−0.61 acetylglucosaminidase, alpha 8341 HIST1H2BN histone cluster 2.910.70 −0.94 0.44 1, H2bn 2519 FUCA2 fucosidase, 2.90 0.53 −0.11 0.73alpha-L-2, plasma 8985 PLOD3 procollagen- 2.88 −0.01 −0.40 −0.24 lysine,2- oxoglutarate 5-dioxygenase 3 1690 COCH cochlin 2.87 1.54 0.02 0.1851114 ZDHHC9 zinc finger, 2.86 −0.02 0.17 0.23 DHHC-type containing 955907 CMAS cytidine 2.85 1.20 −0.01 0.04 monophosphate N-acetylneuraminic acid synthetase 144811 LACC1 laccase 2.84 0.36 −0.910.83 (multicopper oxidoreductase) domain containing 1 92421 CHMP4Ccharged 2.84 0.78 −0.20 −0.06 multivesicular body protein 4C 23475 QPRTquinolinate 2.83 0.37 0.89 −0.26 phosphoribosyltransferase 54913 RPP25ribonuclease 2.77 −0.43 0.75 −0.35 P/MRP 25 kDa subunit 4645 MYO5Bmyosin VB 2.76 −0.18 −0.49 −1.23 9917 FAM20B family with 2.74 0.12 −0.530.50 sequence similarity 20, member B 57213 SPRYD7 SPRY domain 2.73−1.19 −0.63 −0.47 containing 7 113829 SLC35A4 solute carrier 2.73 0.871.35 −0.10 family 35, member A4 100128164 LOC100128164 four and a half2.72 0.42 0.07 0.32 LIM domains 1 pseudogene 26284 ERAL1 Era-like 12S2.70 −0.05 0.90 0.35 mitochondrial rRNA chaperone 1 64847 SPATA20spermatogenesis 2.70 −0.42 0.01 0.46 associated 20 55974 SLC50A1 solutecarrier 2.69 0.40 0.27 0.44 family 50 (sugar efflux transporter), member1 64405 CDH22 cadherin 22, 2.68 −0.66 0.02 0.78 type 2 6510 SLC1A5solute carrier 2.68 0.25 1.07 0.13 family 1 (neutral amino acidtransporter), member 5 196463 PLBD2 phospholipase 2.67 −1.07 −0.43 0.96B domain containing 2 741 ZNHIT2 zinc finger, 2.67 0.67 0.08 0.56HIT-type containing 2 23568 ARL2BP ADP- 2.66 −0.14 0.26 −0.22ribosylation factor-like 2 binding protein 79144 PPDPF pancreatic 2.660.31 0.19 −0.47 progenitor cell differentiation and proliferation factor91319 DERL3 derlin 3 2.66 −0.62 0.03 −0.15 79654 HECTD3 HECT domain 2.640.18 −0.01 0.20 containing E3 ubiquitin protein ligase 3 115950 ZNF653zinc finger 2.63 0.27 0.87 0.00 protein 653 1374 CPT1A carnitine 2.630.10 −0.31 −0.13 palmitoyltransferase 1A (liver) 81533 ITFG1 integrinalpha 2.62 0.64 −0.23 0.72 FG-GAP repeat containing 1 201931 TMEM192transmembrane 2.60 0.09 0.73 −0.14 protein 192 7979 SHFM1 splithand/foot 2.60 1.12 −0.09 −0.10 malformation (ectrodactyly) type 1159296 NKX2-3 NK2 2.59 0.50 1.03 1.28 homeobox 3 51102 MECRmitochondrial 2.59 0.16 0.07 0.17 trans-2-enoyl- CoA reductase 8729 GBF1golgi 2.59 1.24 −0.79 0.52 brefeldin A resistant guanine nucleotideexchange factor 1 118460 EXOSC6 exosome 2.58 0.83 −0.62 0.09 component 679586 CHPF chondroitin 2.57 0.08 −0.01 −0.27 polymerizing factor 2052EPHX1 epoxide 2.54 0.28 −0.62 −0.70 hydrolase 1, microsomal (xenobiotic)84893 FBXO18 F-box protein, 2.53 0.06 −0.86 0.82 helicase, 18 54726OTUD4 OTU domain 2.53 −0.54 0.74 −0.10 containing 4 813 CALU calumenin2.53 0.77 −0.57 −0.59 54431 DNAJC10 DnaJ (Hsp40) 2.52 −0.14 −0.64 −0.26homolog, subfamily C, member 10 9612 NCOR2 nuclear 2.52 0.79 0.41 1.31receptor corepressor 2 9829 DNAJC6 DnaJ (Hsp40) 2.51 −1.46 −1.60 0.51homolog, subfamily C, member 6 79036 KXD1 KxDL motif 2.51 1.09 1.96 0.12containing 1 284361 EMC10 ER membrane 2.51 0.39 −0.02 −0.10 proteincomplex subunit 10 131118 DNAJC19 DnaJ (Hsp40) 2.50 −0.86 −0.69 −0.12homolog, subfamily C, member 19 644809 C15orf56 chromosome 2.50 1.270.33 −0.45 15 open reading frame 56 2119 ETV5 ets variant 5 2.50 −0.01−0.98 0.28 5833 PCYT2 phosphate 2.50 0.56 −0.12 −0.20cytidylyltransferase 2, ethanolamine 922 CD5L CD5 2.49 −0.83 −0.01 −0.54molecule-like 9261 MAPKAPK2 mitogen- 2.49 0.73 0.00 −0.02 activatedprotein kinase- activated protein kinase 2 57190 SEPN1 selenoprotein2.49 0.30 −2.37 −0.29 N, 1 79644 SRD5A3 steroid 5 2.48 0.19 −0.30 −1.11alpha- reductase 3 79058 ASPSCR1 alveolar soft 2.48 1.16 −0.14 −0.09part sarcoma chromosome region, candidate 1 7832 BTG2 BTG family, 2.470.09 −0.36 −0.33 member 2 11070 TMEM115 transmembrane 2.47 0.04 0.530.48 protein 115 10847 SRCAP Snf2-related 2.46 0.51 0.46 −1.01 CREBBPactivator protein 4597 MVD mevalonate 2.46 0.97 0.72 0.94 (diphospho)decarboxylase 100506696 PCAT6 prostate 2.45 0.60 0.46 −0.56 cancerassociated transcript 6 (non-protein coding) 100507459 LOC100507459uncharacterized 2.45 −0.40 0.61 0.49 LOC100507459 100130613 CXorf64chromosome 2.45 0.41 −0.67 −0.83 X open reading frame 64 5081 PAX7paired box 7 2.45 0.92 1.45 −0.72 100240728 LOC100240728 uncharacterized2.44 −0.30 0.84 −0.05 LOC100240728 26229 B3GAT3 beta-1,3- 2.44 0.41 0.51−0.10 glucuronyltransferase 3 (glucuronosyltransferase I) 950 SCARB2scavenger 2.44 0.02 −0.02 −0.25 receptor class B, member 2 161882 ZFPM1zinc finger 2.44 −0.12 0.46 0.89 protein, FOG family member 1 5034 P4HBprolyl 4- 2.43 0.81 0.23 −0.36 hydroxylase, beta polypeptide 123355LRRC28 leucine rich 2.43 0.93 0.57 0.85 repeat containing 28 6734 SRPRsignal 2.43 1.45 −0.69 0.11 recognition particle receptor (dockingprotein) 9911 TMCC2 transmembrane 2.43 −0.95 −0.25 0.73 and coiled- coildomain family 2 222642 TSPO2 translocator 2.42 −0.73 −0.46 0.66 protein2 3643 INSR insulin 2.42 0.82 0.91 −0.72 receptor 85462 FHDC1 FH2 domain2.41 −1.49 −0.58 0.18 containing 1 149175 MANEAL mannosidase, 2.40 −0.211.02 −0.57 endo-alpha- like 1819 DRG2 developmentally 2.40 0.10 −0.070.40 regulated GTP binding protein 2 10370 CITED2 Cbp/p300- 2.39 0.05−1.13 −0.29 interacting transactivator, with Glu/Asp- rich carboxy-terminal domain, 2 25792 CIZ1 CDKN1A 2.39 0.29 0.30 −0.16 interactingzinc finger protein 1 4072 EPCAM epithelial cell 2.39 −0.86 −0.35 0.43adhesion molecule 84447 SYVN1 synovial 2.39 0.55 −0.02 −1.26 apoptosisinhibitor 1, synoviolin 527 ATP6V0C ATPase, H+ 2.39 0.82 0.46 0.25transporting, lysosomal 16 kDa, V0 subunit c 10629 TAF6L TAF6-like 2.380.86 0.07 0.15 RNA polymerase II, p300/CBP- associated factor (PCAF)-associated factor, 65 kDa 51150 SDF4 stromal cell 2.38 0.64 −0.15 −0.38derived factor 4 57143 ADCK1 aarF domain 2.37 −0.13 −0.14 −0.63containing kinase 1 682 BSG basigin 2.37 1.54 −0.94 0.51 10139 ARFRP1ADP- 2.37 0.91 −0.06 −0.20 ribosylation factor related protein 1 203238CCDC171 coiled-coil 2.37 0.55 −0.41 −0.27 domain containing 171 54805CNNM2 cyclin M2 2.37 −0.82 0.70 0.73 1200 TPP1 tripeptidyl 2.37 0.44−1.00 0.97 peptidase I 2271 FH fumarate 2.37 1.67 1.85 −0.14 hydratase376412 RNF126P1 ring finger 2.37 0.37 −0.03 0.02 protein 126 pseudogene1 4924 NUCB1 nucleobindin 1 2.37 1.68 −0.36 0.75 55132 LARP1B La 2.370.33 −0.97 −0.07 ribonucleoprotein domain family, member 1B 9650 MTFR1mitochondrial 2.37 0.55 −1.00 0.41 fission regulator 1 29803 REPIN1replication 2.36 0.71 0.46 −1.02 initiator 1 4507 MTAPmethylthioadenosine 2.36 −0.31 −0.03 0.15 phosphorylase 816 CAMK2Bcalcium/calmodulin- 2.36 0.87 0.30 −0.16 dependent protein kinase IIbeta 120379 PIH1D2 PIH1 domain 2.36 −0.30 0.35 −0.39 containing 2 91289LMF2 lipase 2.36 0.26 0.57 −0.74 maturation factor 2 10905 MAN1A2mannosidase, 2.35 −0.51 0.22 0.09 alpha, class 1A, member 2 25930 PTPN23protein 2.35 0.19 −0.75 0.81 tyrosine phosphatase, non-receptor type 2357648 KIAA1522 KIAA1522 2.35 −0.40 0.20 −0.30 7249 TSC2 tuberous 2.351.12 0.34 −0.58 sclerosis 2 55151 TMEM38B transmembrane 2.34 −0.35 −1.27−0.84 protein 38B 160728 SLC5A8 solute carrier 2.33 0.23 1.90 0.52family 5 (sodium/mono carboxylate cotransporter), member 8 148418 SAMD13sterile alpha 2.33 −0.47 −1.02 0.15 motif domain containing 13 646762LOC646762 uncharacterized 2.32 −0.74 0.22 0.58 LOC646762 79109 MAPKAP1mitogen- 2.32 1.94 1.42 −0.40 activated protein kinase associatedprotein 1 81037 CLPTM1L CLPTM1-like 2.31 −0.21 0.34 −0.22 51523 CXXC5CXXC finger 2.29 −0.06 0.22 −0.21 protein 5 55322 C5orf22 chromosome2.29 0.39 0.87 −0.82 5 open reading frame 22 100996671 LOC100996671uncharacterized 2.29 0.80 −0.60 0.34 LOC100996671 55222 LRRC20 leucinerich 2.29 0.23 −0.12 0.22 repeat containing 20 55624 POMGNT1 protein O-2.29 −0.06 0.70 −0.71 linked mannose N- acetylglucosaminyltransferase 1(beta 1,2-) 100505983 LOC100505983 uncharacterized 2.28 −1.93 −0.81 0.07LOC100505983 3069 HDLBP high density 2.28 −0.16 0.12 −0.65 lipoproteinbinding protein 10959 TMED2 transmembrane 2.28 0.83 0.00 −0.50 emp24domain trafficking protein 2 6598 SMARCB1 SWI/SNF 2.28 1.36 0.07 −0.79related, matrix associated, actin dependent regulator of chromatin,subfamily b, member 1 60412 EXOC4 exocyst 2.27 1.43 −0.21 0.74 complexcomponent 4 54982 CLN6 ceroid- 2.27 −0.12 1.03 −0.50 lipofuscinosis,neuronal 6, late infantile, variant 91752 ZNF804A zinc finger 2.27 1.42−0.14 0.19 protein 804A 113178 SCAMP4 secretory 2.26 1.06 −0.85 0.25carrier membrane protein 4 10 NAT2 N- 2.26 0.44 −0.98 1.14acetyltransferase 2 (arylamine N- acetyltransferase) 375 ARF1 ADP- 2.261.14 0.27 0.39 ribosylation factor 1 5589 PRKCSH protein kinase 2.260.76 −0.28 −0.42 C substrate 80K-H 9136 RRP9 ribosomal 2.26 0.58 1.040.45 RNA processing 9, small subunit (SSU) processome component, homolog(yeast) 23193 GANAB glucosidase, 2.26 0.68 −0.80 −0.03 alpha; neutral AB1798 DPAGT1 dolichyl- 2.25 0.11 0.64 −1.27 phosphate (UDP-N-acetylglucosamine) N- acetylglucosaminephosphotransferase 1 (GlcNAc-1-Ptransferase) 85440 DOCK7 dedicator of 2.25 0.22 −0.02 −0.61 cytokinesis7 100505794 LOC100505794 uncharacterized 2.24 −0.85 −1.84 −0.01LOC100505794 1173 AP2M1 adaptor- 2.24 0.69 0.34 0.20 related proteincomplex 2, mu 1 subunit 124540 MSI2 musashi 2.24 0.42 0.40 0.33RNA-binding protein 2 8372 HYAL3 hyaluronoglucosaminidase 3 2.24 −0.170.81 −0.39 64755 C16orf58 chromosome 2.24 0.26 −0.77 −0.46 16 openreading frame 58 79102 RNF26 ring finger 2.24 0.59 0.25 −0.41 protein 2610963 STIP1 stress- 2.24 1.54 0.24 0.38 induced- phosphoprotein 1 375387NRROS negative 2.24 0.14 −0.62 0.52 regulator of reactive oxygen species972 CD74 CD74 2.23 1.35 0.06 −0.03 molecule, major histocompatibilitycomplex, class II invariant chain 54676 GTPBP2 GTP binding 2.23 1.230.20 1.63 protein 2 192286 HIGD2A HIG1 hypoxia 2.23 0.13 −0.59 0.61inducible domain family, member 2A 3295 HSD17B4 hydroxysteroid 2.23 0.58.25 −0.54 (17-beta) dehydrogenase 4 80852 GRIP2 glutamate 2.23 −1.750.47 0.38 receptor interacting protein 2 1298 COL9A2 collagen, type 2.220.82 0.86 0.11 IX, alpha 2 2004 ELK3 ELK3, ETS- 2.22 −0.85 0.96 −0.24domain protein (SRF accessory protein 2) 10279 PRSS16 protease, 2.220.07 0.07 −0.15 serine, 16 (thymus) 151790 WDR49 WD repeat 2.22 0.390.65 −0.20 domain 49 399664 MEX3D mex-3 RNA 2.21 −0.89 0.64 −0.40binding family member D 5664 PSEN2 presenilin 2 2.21 0.07 −0.24 0.53(Alzheimer disease 4) 51614 ERGIC3 ERGIC and 2.21 0.14 −0.32 −0.36 golgi3 79178 THTPA thiamine 2.21 0.18 1.08 0.08 triphosphatase 51726 DNAJB11DnaJ (Hsp40) 2.20 0.26 0.41 −0.49 homolog, subfamily B, member 11 3425IDUA iduronidase, 2.20 −0.08 −0.06 −0.61 alpha-L- 1642 DDB1 damage- 2.20−0.46 0.93 −0.32 specific DNA binding protein 1, 127 kDa 101928770LOC101928770 uncharacterized 2.19 0.42 −0.39 1.97 LOC101928770 11015KDELR3 KDEL (Lys- 2.19 0.54 −0.29 −1.29 Asp-Glu-Leu) endoplasmicreticulum protein retention receptor 3 35 ACADS acyl-CoA 2.19 1.08 −0.330.02 dehydrogenase, C-2 to C-3 short chain 64798 DEPTOR DEP domain 2.19−0.97 −0.54 −0.53 containing MTOR- interacting protein 23457 ABCB9ATP-binding 2.19 −0.12 1.07 −0.70 cassette, sub- family B (MDR/TAP),member 9 56132 PCDHB3 protocadherin 2.19 0.22 −0.59 1.11 beta 3 23400ATP13A2 ATPase type 2.19 −0.18 −0.61 0.41 13A2 3980 LIG3 ligase III,2.19 −0.46 0.56 0.18 DNA, ATP- dependent 5690 PSMB2 proteasome 2.19 0.250.78 −0.61 (prosome, macropain) subunit, beta type, 2 7917 BAG6 BCL2-2.19 0.11 0.58 −0.49 associated athanogene 6 1739 DLG1 discs, large 2.180.29 −0.28 0.06 homolog 1 (Drosophila) 2837 UTS2R urotensin 2 2.18 1.12−0.79 −1.10 receptor 83746 L3MBTL2 l(3)mbt-like 2 2.18 0.03 0.30 −0.18(Drosophila) 5962 RDX radixin 2.18 0.90 −0.78 −0.53 9956 HS3ST2 heparan2.18 0.67 0.26 −0.67 sulfate (glucosamine) 3-O- sulfotransferase 2162968 ZNF497 zinc finger 2.18 0.06 0.30 −0.31 protein 497 4192 MDKmidkine 2.18 −0.74 −0.74 0.03 (neurite growth- promoting factor 2) 54919HEATR2 HEAT repeat 2.18 0.58 0.20 −1.69 containing 2 10972 TMED10transmembrane 2.17 0.24 0.15 −0.92 emp24-like trafficking protein 10(yeast) 23061 TBC1D9B TBC1 domain 2.17 −0.48 0.44 −0.23 family, member9B (with GRAM domain) 3792 KEL Kell blood 2.17 −0.27 −1.35 1.11 group,metallo- endopeptidase 2063 NR2F6 nuclear 2.17 −0.44 0.57 0.74 receptorsubfamily 2, group F, member 6 55177 RMDN3 regulator of 2.17 −0.50 −0.29−0.19 microtubule dynamics 3 11147 HHLA3 HERV-H 2.17 0.24 −0.04 0.74LTR- associating 3 57486 NLN neurolysin 2.17 1.46 1.23 −0.04(metallopeptidase M3 family) 30814 PLA2G2E phospholipase 2.16 0.03 −0.890.15 A2, group IIE 57414 RHBDD2 rhomboid 2.16 −0.01 −0.77 −0.70 domaincontaining 2 84836 ABHD14B abhydrolase 2.16 −0.24 0.04 −0.02 domaincontaining 14B 8516 ITGA8 integrin, alpha 8 2.16 −0.45 −0.84 −0.31 89866SEC16B SEC16 2.16 −0.12 0.36 1.15 homolog B (S. cerevisiae) 10491 CRTAPcartilage 2.16 −0.69 0.36 0.47 associated protein 11047 ADRM1 adhesion2.16 −0.45 1.09 0.59 regulating molecule 1 28971 AAMDC adipogenesis 2.160.19 0.18 0.52 associated, Mth938 domain containing 8078 USP5 ubiquitin2.16 0.09 0.52 −0.61 specific peptidase 5 (isopeptidase T) 37 ACADVLacyl-CoA 2.16 0.58 −0.03 −0.12 dehydrogenase, very long chain 145508CEP128 centrosomal 2.15 −0.23 0.18 −0.41 protein 128 kDa 49861 CLDN20claudin 20 2.15 0.38 0.63 −0.14 5905 RANGAP1 Ran GTPase 2.15 0.08 0.440.11 activating protein 1 7542 ZFPL1 zinc finger 2.15 1.34 0.05 1.09protein-like 1 9562 MINPP1 multiple 2.15 −0.37 −0.97 −0.14 inositol-polyphosphate phosphatase 1 79095 C9orf16 chromosome 2.15 0.05 0.44 0.569 open reading frame 16 8815 BANF1 barrier to 2.15 1.25 0.40 0.35autointegration factor 1 54867 TMEM214 transmembrane 2.15 1.05 0.54−0.11 protein 214 6721 SREBF2 sterol 2.15 1.52 −1.11 0.63 regulatoryelement binding transcription factor 2 23133 PHF8 PHD finger 2.15 −0.140.85 −1.47 protein 8 113675 SDSL serine 2.14 0.18 0.46 0.40 dehydratase-like 129303 TMEM150A transmembrane 2.14 0.67 −0.67 0.33 protein 150A57658 CALCOCO1 calcium 2.14 −0.17 −0.13 −0.05 binding and coiled-coildomain 1 162 AP1B1 adaptor- 2.14 0.94 1.04 −0.67 related protein complex1, beta 1 subunit 2873 GPS1 G protein 2.14 0.97 0.03 −0.43 pathwaysuppressor 1 64978 MRPL38 mitochondrial 2.14 0.70 −0.93 −0.17 ribosomalprotein L38 220323 OAF OAF homolog 2.14 −0.95 −0.74 0.44 (Drosophila)6006 RHCE Rh blood 2.14 −1.22 −1.53 1.05 group, CcEe antigens 389812LCN15 lipocalin 15 2.14 −0.38 0.83 0.01 2628 GATM glycine 2.13 1.24 0.66−0.73 amidinotransferase (L- arginine:glycine amidinotransferase) 6509SLC1A4 solute carrier 2.13 −0.32 −0.44 −1.07 family 1 (glutamate/neutralamino acid transporter), member 4 3888 KRT82 keratin 82 2.13 −0.02 0.75−0.44 5211 PFKL phosphofructo 2.13 0.63 1.37 −0.29 kinase, liver 55080TAPBPL TAP binding 2.13 0.69 0.59 0.34 protein-like 2139 EYA2 eyesabsent 2.13 −0.64 −0.46 −0.24 homolog 2 (Drosophila) 2030 SLC29A1 solutecarrier 2.12 0.37 0.86 −0.34 family 29 (equilibrative nucleosidetransporter), member 1 56005 C19orf10 chromosome 2.12 0.10 0.03 −0.14 19open reading frame 10 6414 SEPP1 selenoprotein 2.12 −0.17 −1.23 −0.28 P,plasma, 1 5184 PEPD peptidase D 2.12 0.58 1.17 −0.10 643783 USP46- USP462.12 0.11 −0.67 0.36 AS1 antisense RNA 1 101928185 LOC101928185uncharacterized 2.12 0.62 1.07 −0.29 LOC101928185 22883 CLSTN1calsyntenin 1 2.12 −0.88 0.33 −1.64 25800 SLC39A6 solute carrier 2.121.32 −0.10 −0.45 family 39 (zinc transporter), member 6 54681 P4HTMprolyl 4- 2.12 −0.37 −0.25 −0.91 hydroxylase, transmembrane (endoplasmicreticulum) 644150 WIPF3 WAS/WASL 2.12 0.18 −1.20 −0.10 interactingprotein family, member 3 9048 ARTN artemin 2.12 1.14 0.34 −0.47 3054HCFC1 host cell 2.11 −0.38 0.24 0.51 factor C1 (VP16- accessory protein)115098 CCDC124 coiled-coil 2.11 −0.46 0.69 1.79 domain containing 12455558 PLXNA3 plexin A3 2.11 0.55 −0.45 −0.92 675 BRCA2 breast cancer2.11 0.23 0.24 0.06 2, early onset 9777 TM9SF4 transmembrane 9 2.11 0.690.39 −0.54 superfamily protein member 4 83707 TRPT1 tRNA 2.11 0.84 0.89−0.54 phosphotransferase 1 55334 SLC39A9 solute carrier 2.10 1.31 1.47−0.86 family 39, member 9 9793 CKAP5 cytoskeleton 2.10 0.83 0.75 0.01associated protein 5 56834 GPR137 G protein- 2.10 0.97 −1.57 1.00coupled receptor 137 25921 ZDHHC5 zinc finger, 2.10 1.06 1.03 −0.01DHHC-type containing 5 6520 SLC3A2 solute carrier 2.10 0.59 0.18 −0.52family 3 (amino acid transporter heavy chain), member 2 728591 CCDC169coiled-coil 2.10 −0.73 0.49 0.38 domain containing 169 7415 VCP valosin2.10 0.38 0.37 −0.38 containing protein 130827 TMEM182 transmembrane2.09 −0.70 0.39 −0.81 protein 182 9620 CELSR1 cadherin, EGF 2.09 0.64−1.29 0.72 LAG seven- pass G-type receptor 1 55335 NIPSNAP3B nipsnap2.09 0.24 −0.35 0.20 homolog 3B (C. elegans) 84988 PPP1R16A protein 2.080.17 0.65 −0.18 phosphatase 1, regulatory subunit 16A 100192378 ZFHX4-ZFHX4 2.08 −0.02 −0.09 0.21 AS1 antisense RNA 1 442524 DPY19L2P3 DPY19L22.08 −0.04 0.55 −0.86 pseudogene 3 51661 FKBP7 FK506 2.08 0.48 −0.500.03 binding protein 7 84922 FIZ1 FLT3- 2.08 0.63 −0.74 0.21 interactingzinc finger 1 84954 MPND MPN domain 2.08 0.62 1.05 −0.42 containing245972 ATP6V0D2 ATPase, H+ 2.08 0.45 0.17 −0.66 transporting, lysosomal38 kDa, V0 subunit d2 4316 MMP7 matrix 2.08 0.46 0.54 −1.74metallopeptidase 7 (matrilysin, uterine) 55157 DARS2 aspartyl- 2.08 0.581.19 0.48 tRNA synthetase 2, mitochondrial 7466 WFS1 Wolfram 2.08 0.26−0.65 0.19 syndrome 1 (wolframin) 79365 BHLHE41 basic helix- 2.08 0.26−0.23 −0.71 loop-helix family, member e41 10066 SCAMP2 secretory 2.080.03 0.23 0.02 carrier membrane protein 2 203068 TUBB tubulin, beta 2.080.67 0.41 −0.39 class I 5780 PTPN9 protein 2.07 1.31 0.61 −1.20 tyrosinephosphatase, non-receptor type 9 285627 LOC285627 uncharacterized 2.070.41 0.40 0.33 LOC285627 2058 EPRS glutamyl- 2.07 0.11 1.90 −0.12prolyl-tRNA synthetase 1737 DLAT dihydrolipoamide 2.06 0.30 0.31 −1.50S- acetyltransferase 22924 MAPRE3 microtubule- 2.06 1.73 −0.26 −0.87associated protein, RP/EB family, member 3 6005 RHAG Rh-associated 2.06−0.62 −0.69 0.67 glycoprotein 5286 PIK3C2A phosphatidylinositol- 2.060.79 −0.57 0.10 4- phosphate 3- kinase, catalytic subunit type 2 alpha11226 GALNT6 UDP-N- 2.06 0.02 0.84 −0.35 acetyl-alpha- D- galactosamine:polypeptide N- acetylgalactosaminyltransferase 6 (GalNAc-T6) 2762 GMDSGDP- 2.06 0.22 0.98 −0.90 mannose 4,6- dehydratase 8908 GYG2 glycogenin2 2.06 −0.24 −0.32 −0.68 10693 CCT6B chaperonin 2.06 0.21 0.55 0.00containing TCP1, subunit 6B (zeta 2) 199953 TMEM201 transmembrane 2.060.09 0.13 0.12 protein 201 2760 GM2A GM2 2.06 2.00 0.33 0.39 gangliosideactivator 8295 TRRAP transformation/ 2.06 0.95 0.39 −1.52 transcriptiondomain- associated protein 1822 ATN1 atrophin 1 2.06 0.48 −0.10 −0.7755328 RNLS renalase, 2.06 −0.14 0.34 1.00 FAD- dependent amine oxidase2069 EREG epiregulin 2.05 −0.72 −0.16 −0.15 4329 ALDH6A1 aldehyde 2.05−0.31 0.26 −1.79 dehydrogenase 6 family, member A1 537 ATP6AP1 ATPase,H+ 2.05 0.66 −0.23 −0.66 transporting, lysosomal accessory protein 164764 CREB3L2 cAMP 2.05 −0.55 0.39 −0.70 responsive element bindingprotein 3-like 2 811 CALR calreticulin 2.05 −0.06 0.62 −0.98 9779 TBC1D5TBC1 domain 2.05 0.62 1.10 0.35 family, member 5 114815 SORCS1 sortilin-2.05 −1.22 −0.43 −0.11 related VPS10 domain containing receptor 1 29927SEC61A1 Sec61 alpha 1 2.05 0.72 0.17 −0.26 subunit (S. cerevisiae) 6007RHD Rh blood 2.05 0.25 −0.06 0.38 group, D antigen 5192 PEX10peroxisomal 2.05 0.52 0.47 −0.95 biogenesis factor 10 125875 CLDND2claudin 2.04 −0.13 0.77 −0.29 domain containing 2 10882 C1QL1 complement2.04 0.92 0.57 0.80 component 1, q subcomponent- like 1 192683 SCAMP5secretory 2.04 −0.03 −0.60 −0.44 carrier membrane protein 5 8028 MLLT10myeloid/lymphoid 2.04 0.60 0.73 0.59 or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10 150368 FAM109Bfamily with 2.04 −0.82 0.11 0.24 sequence similarity 109, member B 84206MEX3B mex-3 RNA 2.04 −0.09 0.73 0.38 binding family member B 101929288LOC101929288 uncharacterized 2.04 −0.50 −0.12 −0.51 LOC101929288 826CAPNS1 calpain, small 2.04 0.93 0.42 0.36 subunit 1 83440 ADPGK ADP-2.04 0.83 0.18 −0.39 dependent glucokinase 1128 CHRM1 cholinergic 2.030.85 0.38 −0.13 receptor, muscarinic 1 160287 LDHAL6A lactate 2.03 −0.04−1.64 0.41 dehydrogenase A-like 6A 412 STS steroid 2.03 1.18 0.39 0.83sulfatase (microsomal), isozyme S 64215 DNAJC1 DnaJ (Hsp40) 2.03 −0.78−0.10 0.34 homolog, subfamily C, member 1 7343 UBTF upstream 2.03 0.610.51 −0.33 binding transcription factor, RNA polymerase I 25840 METTL7Amethyltransferase 2.03 −0.80 −0.40 0.64 like 7A 55315 SLC29A3 solutecarrier 2.03 −0.65 −1.04 0.67 family 29 (equilibrative nucleosidetransporter), member 3 100507513 LOC100507513 uncharacterized 2.03 −1.150.05 0.97 LOC100507513 55704 CCDC88A coiled-coil 2.03 1.88 0.22 0.49domain containing 88A 57604 KIAA1456 KIAA1456 2.03 −0.16 −0.62 0.4910449 ACAA2 acetyl-CoA 2.03 1.55 0.62 1.05 acyltransferase 2 1727 CYB5R3cytochrome 2.03 0.58 0.39 0.45 b5 reductase 3 9569 GTF2IRD1 GTF2I repeat2.03 0.08 0.45 −0.51 domain containing 1 10009 ZBTB33 zinc finger 2.020.68 0.25 −0.42 and BTB domain containing 33 5188 PET112 PET112 2.020.76 −0.91 −0.05 homolog (yeast) 2132 EXT2 exostosin 2.02 −1.04 −0.770.03 glycosyltransferase 2 2239 GPC4 glypican 4 2.02 0.42 0.29 −0.6656927 GPR108 G protein- 2.02 1.42 −0.90 0.43 coupled receptor 108 2950GSTP1 glutathione S- 2.02 0.83 0.88 0.20 transferase pi 1 342538 NACA2nascent 2.02 −0.55 0.84 −0.30 polypeptide- associated complex alphasubunit 2 55218 EXD2 exonuclease 2.02 −1.15 0.39 −0.59 3′-5′ domaincontaining 2 151827 LRRC34 leucine rich 2.01 0.27 −0.27 −0.19 repeatcontaining 34 64689 GORASP1 golgi 2.01 0.93 −0.18 0.50 reassemblystacking protein 1, 65 kDa 10324 KLHL41 kelch-like 2.01 0.59 −0.19 −0.04family member 41 1314 COPA coatomer 2.01 0.99 0.14 0.28 protein complex,subunit alpha 54928 IMPAD1 inositol 2.01 0.18 −0.91 0.38 monophosphatasedomain containing 1 8971 H1FX H1 histone 2.01 −0.07 0.18 0.12 family,member X 79832 QSER1 glutamine and 2.01 −0.02 −0.81 0.24 serine rich 110150 MBNL2 muscleblind- 2.00 0.03 −0.91 0.81 like splicing regulator 28744 TNFSF9 tumor 2.00 1.07 1.23 −0.89 necrosis factor (ligand)superfamily, member 9 23287 AGTPBP1 ATP/GTP −2.00 0.35 −0.29 −0.37binding protein 1 606553 C8orf49 chromosome −2.00 0.29 0.31 −1.93 8 openreading frame 49 103 ADAR adenosine −2.01 0.26 0.29 0.17 deaminase,RNA-specific 55509 BATF3 basic leucine −2.01 0.59 0.32 0.49 zippertranscription factor, ATF- like 3 729614 FLJ37453 uncharacterized −2.010.28 −0.34 0.59 LOC729614 9241 NOG noggin −2.01 −0.80 0.41 −1.06 26118WSB1 WD repeat −2.01 1.16 −0.20 0.02 and SOCS box containing 1 64400AKTIP AKT −2.01 0.09 −0.33 −0.94 interacting protein 283237 TTC9Ctetratricopeptide −2.01 0.08 0.60 −0.31 repeat domain 9C 51155 HN1hematological −2.01 0.74 1.29 0.20 and neurological expressed 1 18 ABAT4- −2.01 0.33 0.20 0.86 aminobutyrate aminotransferase 22990 PCNXpecanex −2.01 0.31 −0.50 −0.92 homolog (Drosophila) 23347 SMCHD1structural −2.01 0.42 0.17 −0.12 maintenance of chromosomes flexiblehinge domain containing 1 83988 NCALD neurocalcin −2.01 0.18 1.54 −1.04delta 3428 IFI16 interferon, −2.02 0.40 0.91 −0.30 gamma- inducibleprotein 16 3700 ITIH4 inter-alpha- −2.02 0.45 −0.47 1.50 trypsininhibitor heavy chain family, member 4 64859 NABP1 nucleic acid −2.020.54 −0.50 −0.09 binding protein 1 55192 DNAJC17 DnaJ (Hsp40) −2.02 0.39−0.28 0.68 homolog, subfamily C, member 17 101928869 LOC101928869uncharacterized −2.02 0.74 1.59 −0.82 LOC101928869 10513 APPBP2 amyloidbeta −2.02 −0.07 −0.32 −0.95 precursor protein (cytoplasmic tail)binding protein 2 11009 IL24 interleukin 24 −2.02 −0.42 1.84 −1.37169355 IDO2 indoleamine −2.02 −1.28 0.08 0.42 2,3- dioxygenase 2 10109ARPC2 actin related −2.02 0.60 0.53 −0.23 protein 2/3 complex, subunit2, 34 kDa 9903 KLHL21 kelch-like −2.02 0.11 0.37 −0.40 family member 2123150 FRMD4B FERM −2.03 0.52 −1.03 −0.23 domain containing 4B 10865ARID5A AT rich −2.03 1.11 −0.22 −0.06 interactive domain 5A (MRF1-like)5165 PDK3 pyruvate −2.03 0.23 −0.04 0.48 dehydrogenase kinase, isozyme 357403 RAB22A RAB22A, −2.03 0.07 −0.46 −0.43 member RAS oncogene family22900 CARD8 caspase −2.03 0.12 −0.63 0.28 recruitment domain family,member 8 80345 ZSCAN16 zinc finger −2.03 0.25 0.38 −0.29 and SCAN domaincontaining 16 10964 IFI44L interferon- −2.03 0.51 0.65 1.14 inducedprotein 44- like 27040 LAT linker for −2.03 −1.26 0.22 0.00 activationof T cells 91010 FMNL3 formin-like 3 −2.03 −0.46 0.53 −1.06 29065 ASAP1-ASAP1 −2.04 −0.05 −0.37 0.50 IT1 intronic transcript 1 (non-proteincoding) 84078 KBTBD7 kelch repeat −2.04 0.25 0.37 −0.64 and BTB (POZ)domain containing 7 101927910 LOC101927910 keratin- −2.04 −0.79 0.910.09 associated protein 5-5- like 51380 CSAD cysteine −2.04 0.77 −0.680.23 sulfinic acid decarboxylase 10289 EIF1B eukaryotic −2.04 −0.15−0.05 0.65 translation initiation factor 1B 10296 MAEA macrophage −2.040.53 0.45 −0.22 erythroblast attacher 114224 PRO2852 uncharacterized−2.04 −0.57 −0.16 0.15 protein PRO2852 2153 F5 coagulation −2.04 −0.02−0.21 0.56 factor V (proaccelerin, labile factor) 55825 PECR peroxisomal−2.04 0.44 −0.03 0.40 trans-2-enoyl- CoA reductase 6503 SLA Src-like-−2.04 −1.37 −0.53 −0.03 adaptor 7913 DEK DEK −2.04 0.66 0.32 −0.64oncogene 30834 ZNRD1 zinc ribbon −2.04 0.24 2.03 −1.06 domain containing1 26999 CYFIP2 cytoplasmic −2.05 −0.51 0.45 −0.46 FMR1 interactingprotein 2 286437 LOC286437 uncharacterized −2.05 −0.30 −0.30 0.06LOC286437 4277 MICB MHC class I −2.05 −0.08 0.21 −0.19 polypeptide-related sequence B 5698 PSMB9 proteasome −2.05 −0.12 1.18 0.14 (prosome,macropain) subunit, beta type, 9 4318 MMP9 matrix −2.05 0.33 −1.02 −0.43metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IVcollagenase) 10616 RBCK1 RanBP-type −2.06 1.08 0.35 0.94 and C3HC4- typezinc finger containing 1 23012 STK38L serine/threonine −2.06 0.24 −0.560.06 kinase 38 like 100129361 LOC100129361 chromosome −2.06 −0.72 −1.531.08 X open reading frame 69-like 10742 RAI2 retinoic acid −2.06 −0.160.32 −1.10 induced 2 196264 MPZL3 myelin protein −2.06 0.06 −0.05 −0.10zero-like 3 27197 GPR82 G protein- −2.06 −0.33 0.39 0.98 coupledreceptor 82 7529 YWHAB tyrosine 3- −2.06 −0.33 0.35 −0.87 monooxygenase/tryptophan 5- monooxygenase activation protein, beta polypeptide 94235GNG8 guanine −2.06 0.07 0.57 1.14 nucleotide binding protein (Gprotein), gamma 8 352961 HCG26 HLA complex −2.06 −0.34 0.92 −0.34 group26 (non-protein coding) 49856 WRAP73 WD repeat −2.06 0.36 0.65 −0.16containing, antisense to TP73 9448 MAP4K4 mitogen- −2.06 −0.11 −0.96−0.07 activated protein kinase kinase kinase kinase 4 9525 VPS4Bvacuolar −2.06 −0.15 −0.27 −1.47 protein sorting 4 homolog B (S.cerevisiae) 100505576 LINC00672 long −2.06 −0.65 −1.38 0.24 intergenicnon-protein coding RNA 672 151556 GPR155 G protein- −2.06 0.09 0.08−0.13 coupled receptor 155 284613 CYB561D1 cytochrome −2.06 −0.63 0.38−0.70 b561 family, member D1 286223 C9orf47 chromosome −2.06 −0.58 1.330.81 9 open reading frame 47 57061 HYMAI hydatidiform −2.06 0.13 1.06−0.57 mole associated and imprinted (non-protein coding) 9520 NPEPPSaminopeptidase −2.07 0.62 0.08 0.22 puromycin sensitive 202299 C5orf27chromosome −2.07 −0.25 0.66 1.19 5 open reading frame 27 2015 EMR1egf-like −2.07 0.55 0.65 0.29 module containing, mucin-like, hormonereceptor-like 1 57763 ANKRA2 ankyrin −2.07 −0.20 −1.67 −0.42 repeat,family A (RFXANK- like), 2 54778 RNF111 ring finger −2.07 0.23 −0.89−1.05 protein 111 762 CA4 carbonic −2.07 0.62 −0.41 0.08 anhydrase IV192668 CYS1 cystin 1 −2.08 −0.24 0.82 0.06 24146 CLDN15 claudin 15 −2.08−1.46 0.60 0.44 54843 SYTL2 synaptotagmin- −2.08 −2.09 −0.12 −0.38 like2 55374 TMCO6 transmembrane −2.08 −0.03 0.41 −0.36 and coiled- coildomains 6 79603 CERS4 ceramide −2.08 −0.47 1.17 0.72 synthase 4 3577CXCR1 chemokine −2.08 0.24 0.01 −0.45 (C—X—C motif) receptor 1 10385BTN2A2 butyrophilin, −2.08 −0.42 0.63 −0.30 subfamily 2, member A2 79792GSDMD gasdermin D −2.08 0.07 0.24 0.78 84674 CARD6 caspase −2.09 −0.13−0.05 0.28 recruitment domain family, member 6 51131 PHF11 PHD finger−2.09 −0.45 0.25 −2.32 protein 11 5966 REL v-rel avian −2.09 0.51 −0.200.66 reticuloendotheliosis viral oncogene homolog 9733 SART3 squamouscell −2.09 −0.26 0.49 0.20 carcinoma antigen recognized by T cells 310328 EMC8 ER membrane −2.09 0.24 0.80 0.87 protein complex subunit 8255231 MCOLN2 mucolipin 2 −2.09 0.64 1.81 −0.22 25801 GCA grancalcin,−2.09 −0.11 0.32 −0.21 EF-hand calcium binding protein 6352 CCL5chemokine −2.09 −1.08 0.65 0.03 (C-C motif) ligand 5 54811 ZNF562 zincfinger −2.09 −1.12 0.98 −0.04 protein 562 59348 ZNF350 zinc finger −2.090.46 −0.12 −0.32 protein 350 9967 THRAP3 thyroid −2.09 0.95 0.42 0.34hormone receptor associated protein 3 2533 FYB FYN binding −2.10 −0.23−0.56 0.49 protein 28985 MCTS1 malignant T −2.10 −0.66 −0.50 −1.27 cellamplified sequence 1 55234 SMU1 smu-1 −2.10 0.13 −0.04 −0.20 suppressorof mec-8 and unc-52 homolog (C. elegans) 1301 COL11A1 collagen, type−2.10 0.31 0.13 1.14 XI, alpha 1 84803 AGPAT9 1- −2.10 0.07 −0.17 0.02acylglycerol- 3-phosphate O- acyltransferase 9 100506779 BZRAP1- BZRAP1−2.10 −0.43 0.34 0.18 AS1 antisense RNA 1 197135 PATL2 protein −2.10−0.08 0.66 0.09 associated with topoisomerase II homolog 2 (yeast) 3614IMPDH1 IMP (inosine −2.10 0.10 1.24 0.26 5′- monophosphate)dehydrogenase 1 80781 COL18A1 collagen, type −2.10 −1.15 −0.88 −0.81XVIII, alpha 1 5586 PKN2 protein kinase −2.11 −0.01 −1.33 −1.12 N2 79415C17orf62 chromosome −2.11 0.36 0.69 −0.55 17 open reading frame 62 8893EIF2B5 eukaryotic −2.11 −0.42 0.14 0.02 translation initiation factor2B, subunit 5 epsilon, 82 kDa 79736 TEFM transcription −2.11 0.10 −0.380.03 elongation factor, mitochondrial 5770 PTPN1 protein −2.11 −0.21−0.09 0.43 tyrosine phosphatase, non-receptor type 1 9360 PPIGpeptidylprolyl −2.11 0.14 −1.09 −0.02 isomerase G (cyclophilin G) 29940DSE dermatan −2.11 0.22 0.11 0.18 sulfate epimerase 7150 TOP1topoisomerase −2.11 0.15 0.58 1.17 (DNA) I 84964 ALKBH6 alkB, −2.11 0.050.45 0.79 alkylation repair homolog 6 (E. coli) 10614 HEXIM1hexamethylene −2.11 −0.43 −0.78 1.49 bis- acetamide inducible 1 147923ZNF420 zinc finger −2.12 −1.30 −0.74 −0.71 protein 420 284029 LINC00324long −2.12 −0.70 −0.55 0.21 intergenic non-protein coding RNA 324 54952TRNAU1AP tRNA −2.12 0.49 0.10 0.73 selenocysteine 1 associated protein 157476 GRAMD1B GRAM −2.12 −0.35 1.18 0.80 domain containing 1B 8745ADAM23 ADAM −2.12 0.14 −0.79 0.23 metallopeptidase domain 23 22928SEPHS2 selenophosphate −2.12 0.48 −0.36 −0.41 synthetase 2 25880 TMEM186transmembrane −2.12 −0.84 0.69 −0.26 protein 186 28638 TRBC2 T cellreceptor −2.12 −0.74 0.65 0.15 beta constant 2 29933 GPR132 G protein-−2.12 1.64 −0.07 −0.04 coupled receptor 132 30009 TBX21 T-box 21 −2.12−1.00 1.25 0.12 3554 IL1R1 interleukin 1 −2.12 0.17 −0.48 −0.46receptor, type I 8821 INPP4B inositol −2.12 −1.19 −0.83 0.02polyphosphate- 4- phosphatase, type II, 105 kDa 10943 MSL3 male-specific−2.12 0.46 0.07 0.11 lethal 3 homolog (Drosophila) 57724 EPG5 ectopic P-−2.12 −0.33 −0.06 0.11 granules autophagy protein 5 homolog (C. elegans)100506282 LOC100506282 uncharacterized −2.13 0.16 0.83 1.50 LOC100506282147699 PPM1N protein −2.13 −1.19 −0.54 0.79 phosphatase, Mg2+/Mn2+dependent, 1N (putative) 3002 GZMB granzyme B −2.13 −1.41 0.38 0.70(granzyme 2, cytotoxic T- lymphocyte- associated serine esterase 1)389320 C5orf48 chromosome −2.13 0.36 0.46 −0.93 5 open reading frame 489914 ATP2C2 ATPase, −2.13 −0.05 −0.48 −0.11 Ca++ transporting, type 2C,member 2 10804 GJB6 gap junction −2.13 0.05 −0.09 −0.70 protein, beta 6,30 kDa 51439 FAM8A1 family with −2.13 −0.42 −1.15 −0.36 sequencesimilarity 8, member A1 814 CAMK4 calcium/calmodulin- −2.13 0.28 0.240.04 dependent protein kinase IV 5272 SERPINB9 serpin −2.13 0.11 1.700.00 peptidase inhibitor, clade B (ovalbumin), member 9 8428 STK24serine/threonine −2.13 −0.94 0.54 0.28 kinase 24 23048 FNBP1 formin−2.14 −0.45 1.48 0.04 binding protein 1 344558 SH3RF3 SH3 domain −2.140.78 −0.14 −0.92 containing ring finger 3 79078 C1orf50 chromosome −2.14−0.55 1.96 1.42 1 open reading frame 50 81606 LBH limb bud and −2.14−1.45 0.75 −0.43 heart development 64377 CHST8 carbohydrate −2.14 −0.270.39 −0.34 (N- acetylgalactosamine 4-0) sulfotransferase 8 57501KIAA1257 KIAA1257 −2.14 −0.35 −0.74 0.39 5991 RFX3 regulatory −2.14 0.67−0.98 0.29 factor X, 3 (influences HLA class II expression) 90075 ZNF30zinc finger −2.14 −0.45 0.73 −0.98 protein 30 375341 C3orf62 chromosome−2.14 0.54 0.27 0.16 3 open reading frame 62 100130548 LOC100130548uncharacterized −2.15 −0.60 0.80 0.14 LOC100130548 114786 XKR4 XK, Kell−2.15 −0.80 −0.51 −0.43 blood group complex subunit- related family,member 4 150084 IGSF5 immunoglobulin −2.15 0.53 0.83 −0.22 superfamily,member 5 55012 PPP2R3C protein −2.15 0.50 −0.18 0.28 phosphatase 2,regulatory subunit B”, gamma 147525 LINC00526 long −2.15 0.01 −0.55 0.90intergenic non-protein coding RNA 526 54557 SGTB small −2.15 0.23 −0.780.10 glutamine- rich tetratricopeptide repeat (TPR)- containing, beta56267 CCBL2 cysteine −2.15 0.68 0.94 −1.30 conjugate- beta lyase 2 51176LEF1 lymphoid −2.15 −0.06 −0.04 0.50 enhancer- binding factor 1 10468FST follistatin −2.15 −0.20 0.87 0.11 23258 DENND5A DENN/MADD −2.15 0.120.07 −0.02 domain containing 5A 90768 MGC45800 uncharacterized −2.15−1.02 1.59 0.00 LOC90768 134957 STXBP5 syntaxin −2.16 0.01 −0.56 −0.01binding protein 5 (tomosyn) 80342 TRAF3IP3 TRAF3 −2.16 −0.22 1.35 −0.63interacting protein 3 91351 DDX60L DEAD (Asp- −2.16 0.33 −0.81 −0.18Glu-Ala-Asp) box polypeptide 60-like 29916 SNX11 sorting nexin −2.160.44 0.38 0.62 11 8519 IFITM1 interferon −2.16 0.04 0.54 0.00 inducedtransmembrane protein 1 2113 ETS1 v-ets avian −2.16 −0.22 1.20 −0.30erythroblastosis virus E26 oncogene homolog 1 55770 EXOC2 exocyst −2.160.23 −0.28 −2.07 complex component 2 91833 WDR20 WD repeat −2.16 0.26−0.47 −0.62 domain 20 117177 RAB3IP RAB3A −2.16 −0.84 −0.71 0.52interacting protein 546 ATRX alpha −2.16 0.61 0.17 0.22thalassemia/mental retardation syndrome X- linked 4253 CTAGE5 CTAGE−2.17 −0.29 −0.89 −0.52 family, member 5 23214 XPO6 exportin 6 −2.170.22 0.51 −0.08 53347 UBASH3A ubiquitin −2.17 −0.77 0.40 0.23 associatedand SH3 domain containing A 56888 KCMF1 potassium −2.17 −1.33 −0.12−0.16 channel modulatory factor 1 777 CACNA1E calcium −2.17 0.75 −0.590.85 channel, voltage- dependent, R type, alpha 1E subunit 100216545KMT2E- KMT2E −2.17 −0.69 −0.17 0.88 AS1 antisense RNA 1 (head to head)8879 SGPL1 sphingosine- −2.17 0.23 −0.11 −1.18 1-phosphate lyase 1 9759HDAC4 histone −2.17 −0.04 0.01 −0.28 deacetylase 4 26578 OSTF1osteoclast −2.18 0.31 −0.12 0.48 stimulating factor 1 4050 LTBlymphotoxin −2.18 −0.37 0.26 0.38 beta (TNF superfamily, member 3) 4236MFAP1 microfibrillar- −2.18 0.04 2.06 −1.26 associated protein 1 54491FAM105A family with −2.18 −0.90 −0.58 −0.19 sequence similarity 105,member A 55847 CISD1 CDGSH iron −2.18 −0.27 −0.72 −0.14 sulfur domain 1100132707 PAXIP1- PAXIP1 −2.19 0.30 0.46 −0.02 AS2 antisense RNA 2 55884WSB2 WD repeat −2.19 0.26 0.47 −0.19 and SOCS box containing 2 83607AMMECR1L AMMECR1- −2.19 −1.27 −0.33 −0.57 like 9252 RPS6KA5 ribosomal−2.19 −0.65 −0.33 −0.72 protein S6 kinase, 90 kDa, polypeptide 5 55119PRPF38B pre-mRNA −2.19 0.01 −0.47 −2.06 processing factor 38B 57520HECW2 HECT, C2 −2.19 0.49 0.23 0.37 and WW domain containing E3ubiquitin protein ligase 2 79818 ZNF552 zinc finger −2.19 0.12 −0.32−0.44 protein 552 8320 EOMES eomesodermin −2.19 −1.37 0.09 0.09 2792GNGT1 guanine −2.19 −1.06 1.52 −0.42 nucleotide binding protein (Gprotein), gamma transducing activity polypeptide 1 54910 SEMA4C semadomain, −2.19 0.12 1.29 −0.78 immunoglobulin domain (Ig), transmembranedomain (TM) and short cytoplasmic domain, (semaphorin) 4C 55114 ARHGAP17Rho GTPase −2.19 1.40 1.57 0.35 activating protein 17 56253 CRTAMcytotoxic and −2.19 −1.83 −1.11 −0.04 regulatory T cell molecule 65082VPS33A vacuolar −2.19 −0.53 0.02 −0.62 protein sorting 33 homolog A (S.cerevisiae) 84719 LINC00260 long −2.20 −0.34 −0.71 −0.06 intergenicnon-protein coding RNA 260 253558 LCLAT1 lysocardiolipin −2.20 −0.69−1.32 −1.73 acyltransferase 1 6777 STAT5B signal −2.20 0.44 0.37 0.15transducer and activator of transcription 5B 80025 PANK2 pantothenate−2.20 −0.25 1.01 0.64 kinase 2 84662 GLIS2 GLIS family −2.20 0.50 0.170.54 zinc finger 2 89890 KBTBD6 kelch repeat −2.20 0.15 −0.79 −1.41 andBTB (POZ) domain containing 6 10390 CEPT1 choline/ethanolamine −2.200.37 −0.08 −0.71 phosphotransferase 1 2841 GPR18 G protein- −2.20 −0.650.95 −0.34 coupled receptor 18 3904 LAIR2 leukocyte- −2.20 −1.10 1.230.37 associated immunoglobulin- like receptor 2 140460 ASB7 ankyrinrepeat −2.20 −0.05 −0.77 0.23 and SOCS box containing 7 9605 VPS9D1 VPS9domain −2.20 0.25 −0.40 0.11 containing 1 283349 RASSF3 Ras −2.21 0.55−0.19 −0.38 association (RalGDS/AF- 6) domain family member 3 51246SHISA5 shisa family −2.21 −0.38 −0.02 −0.61 member 5 148268 ZNF570 zincfinger −2.21 0.02 −1.49 −0.35 protein 570 26589 MRPL46 mitochondrial−2.21 −0.39 0.36 0.93 ribosomal protein L46 7049 TGFBR3 transforming−2.21 −0.97 −0.32 0.21 growth factor, beta receptor III 2791 GNG11guanine −2.21 −0.32 −1.05 0.18 nucleotide binding protein (G protein),gamma 11 51455 REV1 REV1, −2.21 −0.30 −1.28 −1.13 polymerase (DNAdirected) 1178 CLC Charcot- −2.22 −0.06 −0.39 −0.16 Leyden crystalgalectin 79153 GDPD3 glycerophosphodiester −2.22 0.49 −0.68 −0.16phosphodiesterase domain containing 3 101928524 LOC101928524uncharacterized −2.22 0.14 −0.26 −0.07 LOC101928524 11064 CNTRLcentriolin −2.22 0.51 0.62 −0.38 23429 RYBP RING1 and −2.22 −1.24 0.301.60 YY1 binding protein 5170 PDPK1 3- −2.22 0.00 −0.60 0.45phosphoinositide dependent protein kinase-1 10677 AVIL advillin −2.230.30 −0.08 −0.01 3772 KCNJ15 potassium −2.23 0.23 0.26 −0.02 inwardly-rectifying channel, subfamily J, member 15 128061 C1orf131 chromosome−2.23 −0.47 −0.90 −0.33 1 open reading frame 131 50856 CLEC4A C-typelectin −2.23 0.15 0.14 0.43 domain family 4, member A 6198 RPS6KB1ribosomal −2.23 −0.21 −0.73 −0.35 protein S6 kinase, 70 kDa, polypeptide1 101927588 LOC101927588 uncharacterized −2.24 0.09 0.17 −0.36LOC101927588 2000 ELF4 E74-like −2.24 0.39 0.72 −0.14 factor 4 (etsdomain transcription factor) 493753 COA5 cytochrome c −2.24 −0.80 −0.63−1.24 oxidase assembly factor 5 23081 KDM4C lysine (K)- −2.24 −0.52−0.13 −1.00 specific demethylase 4C 4773 NFATC2 nuclear factor −2.24−1.02 0.77 −0.22 of activated T-cells, cytoplasmic, calcineurin-dependent 2 10178 TENM1 teneurin −2.25 −0.12 −0.96 0.43 transmembraneprotein 1 4974 OMG oligodendrocyte −2.25 0.29 −0.19 0.31 myelinglycoprotein 83860 TAF3 TAF3 RNA −2.25 0.12 0.93 0.61 polymerase II,TATA box binding protein (TBP)- associated factor, 140 kDa 91612 CHURC1churchill −2.25 −0.24 0.27 −0.30 domain containing 1 2178 FANCE Fanconi−2.26 −0.56 0.71 −0.52 anemia, complementation group E 55303 GIMAP4GTPase, −2.26 −0.37 0.14 −0.44 IMAP family member 4 221002 RASGEF1ARasGEF −2.26 −0.30 −0.94 −0.21 domain family, member 1A 3930 LBR lamin B−2.26 0.09 0.14 −0.49 receptor 55471 NDUFAF7 NADH −2.26 0.97 −0.55 −0.62dehydrogenase (ubiquinone) complex I, assembly factor 7 9354 UBE4Aubiquitination −2.26 −0.27 −0.43 −2.87 factor E4A 83700 JAM3 junctional−2.26 0.00 −0.65 0.67 adhesion molecule 3 9140 ATG12 autophagy −2.26−0.12 −1.78 1.02 related 12 23526 HMHA1 histocompatibility −2.27 −0.290.34 0.54 (minor) HA-1 23590 PDSS1 prenyl −2.27 1.23 0.14 −1.07(decaprenyl) diphosphate synthase, subunit 1 9270 ITGB1BP1 integrin beta1 −2.27 −0.53 0.25 −0.72 binding protein 1 10627 MYL12A myosin, light−2.27 0.89 0.00 0.29 chain 12A, regulatory, non- sarcomeric 26048 ZNF500zinc finger −2.27 −1.18 0.18 0.15 protein 500 917 CD3G CD3g −2.27 −1.580.01 −0.12 molecule, gamma (CD3- TCR complex) 94039 ZNF101 zinc finger−2.27 0.06 −0.61 −0.07 protein 101 4215 MAP3K3 mitogen- −2.28 0.26 −0.02−0.10 activated protein kinase kinase kinase 3 10663 CXCR6 chemokine−2.28 −1.52 0.47 −0.52 (C—X—C motif) receptor 6 10308 ZNF267 zinc finger−2.28 0.84 −0.65 0.10 protein 267 8527 DGKD diacylglycerol −2.28 0.470.01 0.03 kinase, delta 130 kDa 926 CD8B CD8b −2.28 −0.59 −0.11 −0.36molecule 9619 ABCG1 ATP-binding −2.28 −0.04 −0.78 −0.92 cassette, sub-family G (WHITE), member 1 5998 RGS3 regulator of −2.29 0.44 0.97 1.13G-protein signaling 3 132625 ZFP42 ZFP42 zinc −2.29 0.20 −1.36 0.61finger protein 88455 ANKRD13A ankyrin repeat −2.30 −0.11 −0.08 −0.02domain 13A 3604 TNFRSF9 tumor −2.30 0.91 0.58 −0.73 necrosis factorreceptor superfamily, member 9 100507398 INTS6- INTS6 −2.30 −0.45 −0.550.49 AS1 antisense RNA1 58517 RBM25 RNA binding −2.30 −0.20 0.40 −0.90motif protein 25 51192 CKLF chemokine- −2.31 −0.14 −0.30 −0.10 likefactor 2177 FANCD2 Fanconi −2.31 0.35 −0.30 −0.42 anemia,complementation group D2 57097 PARP11 poly (ADP- −2.31 −0.33 0.54 −0.09ribose) polymerase family, member 11 11214 AKAP13 A kinase −2.31 0.03−0.10 0.38 (PRKA) anchor protein 13 4600 MX2 myxovirus −2.31 0.55 0.950.27 (influenza virus) resistance 2 (mouse) 84255 SLC37A3 solute carrier−2.31 0.14 −0.49 0.05 family 37, member 3 11216 AKAP10 A kinase −2.320.60 0.72 −0.32 (PRKA) anchor protein 10 162417 NAGS N- −2.32 0.51 0.99−0.07 acetylglutamate synthase 101928617 LOC101928617 uncharacterized−2.32 −0.16 −0.52 0.77 LOC101928617 10617 STAMBP STAM −2.32 −0.46 1.22−0.28 binding protein 1326 MAP3K8 mitogen- −2.32 0.35 −0.48 −0.27activated protein kinase kinase kinase 8 23315 SLC9A8 solute carrier−2.32 0.18 0.29 0.24 family 9, subfamily A (NHE8, cation protonantiporter 8), member 8 10791 VAMP5 vesicle- −2.32 0.11 0.52 0.99associated membrane protein 5 8718 TNFRSF25 tumor −2.32 −0.41 −0.63−0.05 necrosis factor receptor superfamily, member 25 51571 FAM49Bfamily with −2.33 −0.21 −0.09 −0.32 sequence similarity 49, member B283521 LINC00282 long −2.33 0.15 −0.37 −0.21 intergenic non-proteincoding RNA 282 51122 COMMD2 COMM −2.33 0.10 −0.79 −0.17 domaincontaining 2 5372 PMM1 phosphomannomutase 1 −2.33 0.90 −0.91 −0.37 9830TRIM14 tripartite motif −2.33 −1.08 0.02 −0.05 containing 14 314 AOC2amine −2.33 −0.51 −0.06 −1.03 oxidase, copper containing 2 (retina-specific) 51761 ATP8A2 ATPase, −2.33 −0.45 0.23 −1.08 aminophospholipidtransporter, class I, type 8A, member 2 493861 EID3 EP300 −2.34 −0.28−0.02 0.74 interacting inhibitor of differentiation 3 6672 SP100 SP100nuclear −2.34 0.20 0.18 0.29 antigen 55578 SUPT20H suppressor of −2.340.36 0.25 −1.31 Ty 20 homolog (S. cerevisiae) 159 ADSS adenylosuccinate−2.34 −0.25 0.57 −1.73 synthase 9683 N4BP1 NEDD4 −2.34 −0.14 −0.22 −0.13binding protein 1 26287 ANKRD2 ankyrin repeat −2.35 0.50 1.19 −0.57domain 2 (stretch responsive muscle) 57147 SCYL3 SCY1-like 3 −2.35 0.42−0.45 −1.01 (S. cerevisiae) 1808 DPYSL2 dihydropyrimidinase- −2.35 1.250.58 0.09 like 2 23355 VPS8 vacuolar −2.35 0.05 −0.51 0.89 proteinsorting 8 homolog (S. cerevisiae) 8115 TCL1A T-cell −2.35 0.74 1.27 0.86leukemia/lymphoma 1A 94120 SYTL3 synaptotagmin- −2.35 −0.12 0.30 −0.73like 3 22950 SLC4A1AP solute carrier −2.35 0.00 0.35 0.02 family 4(anion exchanger), member 1, adaptor protein 27342 RABGEF1 RAB guanine−2.35 0.57 −0.34 −0.05 nucleotide exchange factor (GEF) 1 64926 RASAL3RAS protein −2.35 −0.38 1.18 −0.59 activator like 3 100507331 ZSWIM8-ZSWIM8 −2.36 0.19 0.03 −0.24 AS1 antisense RNA 1 4068 SH2D1A SH2 domain−2.36 −0.89 −0.83 0.04 containing 1A 60481 ELOVL5 ELOVL fatty −2.36 0.400.75 −0.39 acid elongase 5 2634 GBP2 guanylate −2.36 −0.33 −0.07 −0.24binding protein 2, interferon- inducible 55824 PAG1 phosphoprotein −2.36−0.30 −0.42 −0.20 associated with glycosphingolipid microdomains 1 79074C2orf49 chromosome −2.36 0.81 0.03 0.36 2 open reading frame 49 220930ZEB1- ZEB1 −2.36 0.53 −1.05 −1.07 AS1 antisense RNA 1 64421 DCLRE1C DNAcross- −2.36 0.02 −1.42 0.49 link repair 1C 64121 RRAGC Ras-related−2.37 −0.29 0.24 1.00 GTP binding C 137835 TMEM71 transmembrane −2.37−0.30 −0.26 −0.04 protein 71 57674 RNF213 ring finger −2.37 0.30 0.220.34 protein 213 728392 LOC728392 uncharacterized −2.37 0.26 −0.69 −0.19LOC728392 329 BIRC2 baculoviral −2.38 −0.70 −2.00 0.48 IAP repeatcontaining 2 55279 ZNF654 zinc finger −2.38 0.07 −1.37 −0.19 protein 6547107 GPR137B G protein- −2.38 0.31 −0.09 0.76 coupled receptor 137B 9416DDX23 DEAD (Asp- −2.38 0.38 0.91 −0.29 Glu-Ala-Asp) box polypeptide 23137964 AGPAT6 1- −2.38 −0.25 0.41 0.24 acylglycerol- 3-phosphate O-acyltransferase 6 3431 SP110 SP110 nuclear −2.38 0.04 0.94 0.17 bodyprotein 4140 MARK3 MAP/microtubule −2.38 −0.45 −0.24 0.14 affinity-regulating kinase 3 59269 HIVEP3 human −2.38 0.03 −0.99 −0.81immunodeficiency virus type I enhancer binding protein 3 7846 TUBA1Atubulin, alpha −2.38 0.29 −0.02 0.07 1a 100652740 C16orf98 chromosome−2.38 0.39 −1.72 0.89 16 open reading frame 98 23398 PPWD1peptidylprolyl −2.38 0.12 −0.31 −0.95 isomerase domain and WD repeatcontaining 1 158747 MOSPD2 motile sperm −2.39 0.20 −0.33 −0.87 domaincontaining 2 285512 FAM13A- FAM13A −2.39 −0.02 −0.56 0.34 AS1 antisenseRNA1 3937 LCP2 lymphocyte −2.39 −0.40 −0.18 −0.43 cytosolic protein 2(SH2 domain containing leukocyte protein of 76 kDa) 730051 ZNF814 zincfinger −2.39 0.06 0.80 1.10 protein 814 9320 TRIP12 thyroid −2.39 0.320.77 −0.44 hormone receptor interactor 12 6932 TCF7 transcription −2.39−0.20 0.72 −0.19 factor 7 (T- cell specific, HMG-box) 79722 ANKRD55ankyrin repeat −2.39 −0.17 −0.26 0.25 domain 55 115362 GBP5 guanylate−2.39 −0.84 −0.21 0.15 binding protein 5 29909 GPR171 G protein- −2.39−0.45 −0.41 −0.68 coupled receptor 171 440503 PLIN5 perilipin 5 −2.400.00 −0.42 −0.55 80183 KIAA0226L KIAA0226- −2.40 1.05 0.47 0.24 like80709 AKNA AT-hook −2.40 0.01 0.62 −0.58 transcription factor 10562OLFM4 olfactomedin 4 −2.40 −0.05 −0.92 −0.43 64780 MICAL1 microtubule−2.41 0.42 −1.67 −0.46 associated monooxygenase, calponin and LIM domaincontaining 1 155038 GIMAP8 GTPase, −2.41 −0.10 0.79 −0.31 IMAP familymember 8 1783 DYNC1LI2 dynein, −2.41 0.19 −0.77 −0.07 cytoplasmic 1,light intermediate chain 2 100287569 LINC00173 long −2.42 0.45 0.86 0.65intergenic non-protein coding RNA 173 5696 PSMB8 proteasome −2.42 0.360.79 0.06 (prosome, macropain) subunit, beta type, 8 11066 SNRNP35 smallnuclear −2.42 0.50 0.48 0.36 ribonucleoprotein 35 kDa (U11/U12) 122553TRAPPC6B trafficking −2.42 0.43 −0.02 −0.27 protein particle complex 6B50484 RRM2B ribonucleotide −2.43 0.65 −0.60 −0.74 reductase M2B (TP53inducible) 9847 C2CD5 C2 calcium- −2.43 −0.11 −0.34 −0.35 dependentdomain containing 5 129285 PPP1R21 protein −2.43 0.74 0.78 −0.73phosphatase 1, regulatory subunit 21 9794 MAML1 mastermind- −2.43 −0.380.25 −1.74 like 1 (Drosophila) 84309 NUDT16L1 nudix −2.43 −0.63 0.850.02 (nucleoside diphosphate linked moiety X)-type motif 16-like 1 65258MPPE1 metallophosphoesterase 1 −2.43 0.16 0.09 −0.45 5562 PRKAA1 protein−2.44 −0.34 −0.85 0.48 kinase, AMP- activated, alpha 1 catalytic subunit123036 TC2N tandem C2 −2.44 0.01 −0.08 −0.30 domains, nuclear 84166NLRC5 NLR family, −2.45 −0.28 −0.25 −0.33 CARD domain containing 5253143 PRR14L proline rich −2.45 −0.36 −0.38 −0.61 14-like 1236 CCR7chemokine −2.45 0.05 0.49 −0.12 (C-C motif) receptor 7 266747 RGL4 ralguanine −2.46 −0.19 0.00 −0.25 nucleotide dissociation stimulator- like4 25988 HINFP histone H4 −2.46 −0.11 2.05 −0.48 transcription factor6515 SLC2A3 solute carrier −2.46 0.39 0.08 0.20 family 2 (facilitatedglucose transporter), member 3 90592 ZNF700 zinc finger −2.46 0.71 −1.32−0.79 protein 700 6867 TACC1 transforming, −2.47 1.05 −0.07 0.50 acidiccoiled- coil containing protein 1 23041 MON2 MON2 −2.47 0.02 −1.18 −0.17homolog (S. cerevisiae) 100289230 LOC100289230 uncharacterized −2.47−0.65 0.54 −0.02 LOC100289230 57169 ZNFX1 zinc finger, −2.48 0.01 −0.280.54 NFX1-type containing 1 1105 CHD1 chromodomain −2.48 0.32 −1.07 0.09helicase DNA binding protein 1 943 TNFRSF8 tumor −2.48 1.03 1.09 0.96necrosis factor receptor superfamily, member 8 3275 PRMT2 protein −2.480.64 −0.31 0.34 arginine methyltransferase 2 8851 CDK5R1 cyclin- −2.490.52 0.25 −0.10 dependent kinase 5, regulatory subunit 1 (p35) 168537GIMAP7 GTPase, −2.49 −0.53 −0.08 −0.09 IMAP family member 7 256236 NAPSBnapsin B −2.49 0.84 0.02 0.41 aspartic peptidase, pseudogene 26235 FBXL4F-box and −2.50 −0.08 −0.17 0.44 leucine-rich repeat protein 4 9363RAB33A RAB33A, −2.50 −0.30 0.49 0.73 member RAS oncogene family 729683LOC729683 uncharacterized −2.50 0.17 0.43 0.05 LOC729683 388969 C2orf68chromosome −2.51 −0.79 0.31 0.01 2 open reading frame 68 4818 NKG7natural killer −2.51 −0.88 −0.05 0.13 cell group 7 sequence 93953 ACRCacidic repeat −2.51 0.21 −0.99 0.29 containing 28982 FLVCR1 feline −2.510.14 0.27 −2.04 leukemia virus subgroup C cellular receptor 1 84911ZNF382 zinc finger −2.52 −0.59 0.61 −0.52 protein 382 66036 MTMR9myotubularin −2.52 −0.62 −1.12 0.10 related protein 9 9750 FAM65B familywith −2.52 −0.02 0.69 −0.35 sequence similarity 65, member B 9938ARHGAP25 Rho GTPase −2.52 −0.43 −0.14 −0.46 activating protein 25 120425AMICA1 adhesion −2.52 0.03 −0.08 0.09 molecule, interacts with CXADRantigen 1 6840 SVIL supervillin −2.53 −0.28 −0.45 0.12 26268 FBXO9 F-boxprotein 9 −2.53 −1.93 −1.19 0.51 55206 SBNO1 strawberry −2.53 −0.52−1.01 −0.74 notch homolog 1 (Drosophila) 355 FAS Fas cell −2.54 0.710.41 0.30 surface death receptor 50615 IL21R interleukin 21 −2.54 −0.270.71 0.03 receptor 221178 SPATA13 spermatogenesis −2.54 −0.05 0.34 −0.29associated 13 11104 KATNA1 katanin p60 −2.54 0.66 −0.03 −1.98 (ATPasecontaining) subunit A1 1117 CHI3L2 chitinase 3- −2.54 0.43 1.36 −0.47like2 374969 CCDC23 coiled-coil −2.54 0.15 −0.06 0.88 domain containing23 6285 S100B S100 calcium −2.55 −0.38 −1.44 −0.44 binding protein B387357 THEMIS thymocyte −2.55 −0.69 −0.77 −0.13 selection associated2960 GTF2E1 general −2.56 −0.21 0.05 −1.50 transcription factor IIE,polypeptide 1, alpha 56 kDa 100129550 LOC100129550 uncharacterized −2.56−0.35 −0.66 −0.15 LOC100129550 54520 CCDC93 coiled-coil −2.56 0.13 −0.47−0.50 domain containing 93 10302 SNAPC5 small nuclear −2.56 −0.81 0.120.51 RNA activating complex, polypeptide 5, 19 kDa 50939 IMPG2interphotoreceptor −2.56 0.15 0.32 −1.16 matrix proteoglycan 2 8802SUCLG1 succinate- −2.56 −0.31 0.44 −0.77 CoA ligase, alpha subunit 23332CLASP1 cytoplasmic −2.57 0.16 −1.50 −0.09 linker associated protein 1203328 SUSD3 sushi domain −2.57 0.78 −0.01 0.01 containing 3 126231ZNF573 zinc linger −2.58 −0.54 0.54 −1.59 protein 573 6993 DYNLT1dynein, light −2.58 −0.22 0.12 0.22 chain, Tctex- type 1 58500 ZNF250zinc finger −2.59 0.73 0.63 −0.05 protein 250 10507 SEMA4D sema domain,−2.59 0.09 0.59 0.54 immunoglobulin domain (Ig), transmembrane domain(TM) and short cytoplasmic domain, (semaphorin) 4D 170482 CLEC4C C-typelectin −2.59 0.33 1.01 0.08 domain family 4, member C 3004 GZMM granzymeM −2.59 −0.20 −0.15 0.23 (lymphocyte met-ase 1) 64895 PAPOLG poly(A)−2.59 −0.46 −0.57 −0.15 polymerase gamma 7850 IL1R2 interleukin 1 −2.590.24 −0.03 0.07 receptor, type II 93594 TBC1D31 TBC1 domain −2.59 −0.350.31 −1.26 family, member 31 23215 PRRC2C proline-rich −2.60 0.23 0.470.90 coiled-coil 2C 80196 RNF34 ring finger −2.60 −0.06 0.49 −0.53protein 34, E3 ubiquitin protein ligase 284415 VSTM1 V-set and −2.60−0.60 0.30 0.84 transmembrane domain containing 1 56882 CDC42SE1 CDC42small −2.60 −0.19 0.12 −0.34 effector 1 6508 SLC4A3 solute carrier −2.60−0.21 −0.74 0.20 family 4 (anion exchanger), member 3 79663 HSPBAP1 HSPB(heat −2.61 −0.19 0.15 −0.38 shock 27 kDa) associated protein 1 474344GIMAP6 GTPase, −2.61 −0.31 0.86 −0.14 IMAP family member 6 100505746ITGB2- ITGB2 −2.62 0.34 −0.47 0.12 AS1 antisense RNA 1 1293 COL6A3collagen, type −2.62 −0.52 −1.29 −0.64 VI, alpha 3 10294 DNAJA2 DnaJ(Hsp40) −2.62 0.13 0.40 −0.18 homolog, subfamily A, member 2 3091 HIF1Ahypoxia −2.62 0.83 −0.75 −0.17 inducible factor 1, alpha subunit (basichelix-loop- helix transcription factor) 79573 TTC13 tetratricopeptide−2.63 −0.32 −0.92 −0.75 repeat domain 13 9208 LRRFIP1 leucine rich −2.630.81 0.12 −0.23 repeat (in FLII) interacting protein 1 29116 MYLIPmyosin −2.63 −0.28 −0.62 0.05 regulatory light chain interacting protein92370 ACPL2 acid −2.63 −1.54 −0.45 −0.71 phosphatase- like 2 9546 APBA3amyloid beta −2.64 0.21 1.01 −0.23 (A4) precursor protein- binding,family A, member 3 253018 HCG27 HLA complex −2.64 −0.05 0.09 0.27 group27 (non-protein coding) 10096 ACTR3 ARP3 actin- −2.65 0.49 −0.28 0.34related protein 3 homolog (yeast) 84138 SLC7A6OS solute carrier −2.65−0.42 1.70 −0.20 family 7, member 6 opposite strand 8440 NCK2 NCKadaptor −2.65 −1.07 0.79 0.13 protein 2 7277 TUBA4A tubulin, alpha −2.650.48 0.19 0.19 4a 8269 TMEM187 transmembrane −2.66 −0.27 0.56 −1.62protein 187 8807 IL18RAP interleukin 18 −2.66 −0.04 −0.09 0.08 receptoraccessory protein 1235 CCR6 chemokine −2.67 −0.28 1.66 −0.57 (C-C motif)receptor 6 7059 THBS3 thrombospondin 3 −2.67 −0.20 −0.07 −0.91 54971BANP BTG3 −2.67 −0.34 0.29 −0.19 associated nuclear protein 57677 ZFP14ZFP14 zinc −2.68 0.38 −1.14 −0.27 finger protein 6890 TAP1 transporter1, −2.68 0.05 0.37 0.20 ATP-binding cassette, sub- family B (MDR/TAP)22944 KIN KIN, −2.69 0.36 −1.20 −0.67 antigenic determinant of recAprotein homolog (mouse) 26512 INTS6 integrator −2.69 −0.14 0.22 −0.75complex subunit 6 92797 HELB helicase −2.69 0.17 −0.33 0.01 (DNA) B 5481PPID peptidylprolyl −2.70 0.38 1.67 −0.63 isomerase D 22897 CEP164centrosomal −2.71 −0.53 1.08 −0.97 protein 164 kDa 3620 IDO1 indoleamine−2.71 −0.70 0.25 0.59 2,3- dioxygenase 1 64766 S100PBP S100P −2.71 −0.270.58 −1.38 binding protein 8809 IL18R1 interleukin 18 −2.71 0.21 0.39−0.32 receptor 1 116984 ARAP2 ArfGAP with −2.71 −0.28 −0.80 −0.35 RhoGAPdomain, ankyrin repeat and PH domain 2 440823 MIAT myocardial −2.72−0.95 −0.55 −0.22 infarction associated transcript (non-protein coding)59340 HRH4 histamine −2.72 0.21 −0.90 −0.79 receptor H4 197259 MLKLmixed lineage −2.73 0.03 0.50 −0.43 kinase domain-like 23670 TMEM2transmembrane −2.73 0.16 0.22 −0.71 protein 2 643314 KIAA0754 KIAA0754−2.73 0.87 0.06 0.11 28526 TRDC T cell receptor −2.73 −1.25 0.37 0.10delta constant 55096 EBLN2 endogenous −2.74 −0.05 −0.03 0.57 Bornavirus-like nucleoprotein 2 2796 GNRH1 gonadotropin- −2.74 −0.88 0.11 −0.38releasing hormone 1 (luteinizing- releasing hormone) 54509 RHOF rashomolog −2.74 0.31 0.83 1.43 family member F (in filopodia) 11120 BTN2A1butyrophilin, −2.75 0.52 −0.22 −1.12 subfamily 2, member A1 84869 CBR4carbonyl −2.75 0.31 −0.35 −0.28 reductase 4 28991 COMMD5 COMM −2.76 0.410.45 −0.17 domain containing 5 154141 MBOAT1 membrane −2.79 0.06 0.080.22 bound O- acyltransferase domain containing 1 3659 IRF1 interferon−2.79 −0.54 −0.36 −0.28 regulatory factor 1 154007 SNRNP48 small nuclear−2.80 0.44 −0.26 −0.32 ribonucleoprotein 48 kDa (U11/U12) 116835 HSPA12Bheat shock −2.81 0.14 −0.16 0.30 70 kD protein 12B 9488 PIGBphosphatidylinositol −2.82 0.68 0.08 −0.07 glycan anchor biosynthesis,class B 100293516 ZNF587B zinc finger −2.83 −0.09 0.21 −1.06 protein587B 9217 VAPB VAMP −2.84 −1.12 −1.05 −0.01 (vesicle- associatedmembrane protein)- associated protein B and C 10538 BATF basic leucine−2.84 0.51 0.53 0.52 zipper transcription factor, ATF- like 6935 ZEB1zinc finger E- −2.87 0.56 −0.27 −0.22 box binding homeobox 1 10443N4BP2L2 NEDD4 −2.88 −0.84 −1.29 −0.96 binding protein 2-like 2 3837KPNB1 karyopherin −2.88 −1.28 0.25 −0.60 (importin) beta 1 81698LINC00597 long −2.88 −0.07 0.72 −0.14 intergenic non-protein coding RNA597 2643 GCH1 GTP −2.89 0.40 −0.06 0.56 cyclohydrolase 1 57559 STAMBPL1STAM −2.89 0.00 0.60 −0.53 binding protein-like 1 116842 LEAP2 liver−2.89 −0.25 −1.30 −0.48 expressed antimicrobial peptide 2 202 AIM1absent in −2.90 0.49 0.63 −1.01 melanoma 1 9934 P2RY14 purinergic −2.900.11 0.00 0.08 receptor P2Y, G-protein coupled, 14 100216546 LINC01004long −2.90 0.05 −1.36 −0.34 intergenic non-protein coding RNA 1004 9692KIAA0391 KIAA0391 −2.90 0.17 0.26 −1.79 89845 ABCC10 ATP-binding −2.92−0.33 0.85 −1.06 cassette, sub- family C (CFTR/MRP), member 10 26034IPCEF1 interaction −2.92 −0.27 0.37 −0.66 protein for cytohesin exchangefactors 1 10906 TRAFD1 TRAF-type −2.93 0.40 0.36 0.88 zinc finger domaincontaining 1 84811 BUD13 BUD13 −2.94 −0.56 −0.52 −0.18 homolog (S.cerevisiae) 100527964 LOC100527964 uncharacterized −2.96 −0.38 −0.49−1.17 LOC100527964 118426 LOH12CR1 loss of −2.97 0.02 −0.17 −0.21heterozygosity, 12, chromosomal region 1 54331 GNG2 guanine −2.98 0.370.07 −0.18 nucleotide binding protein (G protein), gamma 2 94081 SFXN1sideroflexin 1 −2.99 0.15 −0.22 −0.48 145474 LOC145474 uncharacterized−2.99 0.22 −0.36 0.36 LOC145474 84969 TOX2 TOX high −3.00 0.02 −0.66−0.27 mobility group box family member 2 4907 NT5E 5′- −3.02 0.12 1.19−0.48 nucleotidase, ecto (CD73) 51735 RAPGEF6 Rap guanine −3.03 −0.09−0.81 −0.46 nucleotide exchange factor (GEF) 6 9953 HS3ST3B1 heparan−3.03 −0.12 −1.70 −1.64 sulfate (glucosamine) 3-O- sulfotransferase 3B123112 TNRC6B trinucleotide −3.04 −0.93 0.39 −0.92 repeat containing 6B91526 ANKRD44 ankyrin repeat −3.05 0.24 0.25 −0.51 domain 44 101928017LOC101928017 uncharacterized −3.08 −0.04 −0.52 −0.33 LOC101928017 84859LRCH3 leucine-rich −3.08 −0.37 −0.52 −0.57 repeats and calponin homology(CH) domain containing 3 159013 CXorf38 chromosome −3.11 0.44 0.69 −0.68X open reading frame 38 23208 SYT11 synaptotagmin −3.19 0.00 0.62 −0.55XI 101928649 LOC101928649 uncharacterized −3.23 −0.33 −0.10 1.08LOC101928649 85459 KIAA1731 KIAA1731 −3.28 0.57 0.67 0.61 9617 MTRF1mitochondrial −3.31 0.69 0.22 −0.22 translational release factor 1 56898BDH2 3- −3.50 0.36 0.59 −0.70 hydroxybutyrate dehydrogenase, type 2387882 C12orf75 chromosome −3.61 −0.75 0.39 0.39 12 open reading frame75 677769 SCARNA17 small Cajal −3.64 −1.27 −0.31 0.25 body-specificRNA17 gene 37 38 39 40 41 42 43 44 45 46 47 48 49 56904 0.71 0.24 −0.28−0.23 −0.13 0.98 1.54 1.43 0.73 1.10 1.44 0.98 0.90 6464 −0.27 0.99 1.19−0.30 0.90 1.11 0.57 2.34 1.40 0.45 1.58 0.72 0.74 79087 0.10 −1.45 0.111.19 0.28 −0.15 1.43 1.19 0.41 0.95 1.63 0.72 1.15 101928190 0.31 0.91−1.41 0.23 0.13 1.68 0.42 0.86 0.70 0.39 1.90 −0.10 1.52 3416 −0.57−0.36 1.61 0.57 −0.39 1.73 0.21 1.68 −0.09 1.19 1.50 0.54 1.52 8001 0.981.09 0.47 0.48 1.52 −0.17 1.03 −0.17 0.38 0.08 0.91 2.51 −0.03 3727 1.09−0.01 1.40 −0.11 0.06 1.11 1.34 1.26 0.72 −0.14 2.08 0.75 0.33 109450.81 −0.57 0.88 0.08 0.06 1.39 1.53 1.53 0.60 1.11 1.64 −0.08 1.05 50250.62 −1.94 0.26 −0.16 0.05 1.94 0.87 1.26 1.11 1.26 1.57 0.26 1.03 29920−0.15 −2.15 0.68 0.75 0.48 1.18 1.28 1.23 0.34 1.12 0.99 0.24 0.75101929248 0.01 1.61 0.18 0.53 −0.20 2.59 0.99 1.20 0.97 −0.79 1.22 1.060.49 23646 0.24 −1.13 0.96 0.34 0.11 1.35 1.31 1.68 0.05 1.50 1.28 0.511.07 10280 −0.50 0.10 0.93 0.34 −0.69 1.01 0.31 2.78 0.98 0.78 1.56−0.44 1.14 140699 −0.07 0.94 0.59 −0.16 −0.42 1.76 −0.96 0.53 2.62 0.530.98 0.67 0.42 4669 0.46 −0.07 0.27 −0.03 −0.46 1.51 0.78 2.04 1.01 1.381.43 0.27 1.47 8341 −0.67 0.97 0.77 0.30 −0.01 2.01 1.24 0.65 1.12 0.861.20 0.48 0.38 2519 −0.27 −1.09 0.71 0.23 0.25 1.18 1.07 1.39 −0.27 2.250.60 0.35 1.70 8985 1.02 −1.43 0.95 −0.02 −0.03 1.07 0.69 1.71 0.83 0.141.52 0.71 1.59 1690 0.15 −0.68 1.61 0.98 0.17 −0.16 0.42 1.49 0.75 −0.390.43 1.26 1.76 51114 0.73 −1.38 0.85 −0.58 0.03 1.59 0.00 1.31 1.14 0.511.71 0.63 1.78 55907 0.81 −2.74 0.89 0.74 0.54 0.58 0.73 −0.47 0.55 1.491.08 1.05 1.41 144811 0.37 −0.37 −0.14 0.49 0.06 1.38 0.64 0.73 1.511.22 0.69 0.76 1.00 92421 0.22 1.10 −0.83 1.09 0.01 0.80 −0.05 1.13 0.481.25 1.21 0.87 0.92 23475 1.13 0.03 1.45 0.18 −1.05 2.00 0.68 0.81 0.870.86 0.95 0.15 1.62 54913 −0.37 −0.10 0.09 0.93 −0.40 0.59 1.07 0.840.03 2.18 1.76 0.04 1.03 4645 0.10 1.08 0.83 1.07 −0.70 2.24 −0.22 0.090.28 1.06 1.74 1.21 1.03 9917 0.28 −2.09 1.80 0.57 −0.51 0.78 1.31 0.411.53 1.01 1.80 0.01 0.21 57213 −0.17 −0.47 1.72 0.94 −0.10 0.64 0.210.64 1.98 1.98 0.86 0.23 1.56 113829 −0.15 −1.18 0.18 0.72 −0.67 1.020.55 1.40 0.75 1.65 1.90 −0.25 1.33 100128164 0.00 0.66 0.24 0.79 −0.331.45 0.81 −0.54 2.29 0.34 −0.05 1.56 −0.04 26284 0.49 −0.61 1.23 0.18−1.13 0.39 1.23 1.88 0.52 1.45 1.48 0.12 1.12 64847 0.25 0.15 1.21 0.86−0.40 1.35 0.50 1.60 0.61 0.38 0.91 0.46 1.37 55974 0.44 −1.19 0.22−0.25 −0.17 1.56 1.31 1.64 0.74 0.76 1.89 −0.13 1.52 64405 0.79 2.121.83 −0.24 0.12 0.77 0.44 −0.42 0.71 0.71 1.44 1.18 −0.31 6510 0.83−0.44 0.26 −0.15 −0.18 1.32 1.39 1.65 0.26 0.81 1.40 −0.12 1.32 196463−0.66 0.81 1.69 0.38 −0.60 0.20 0.29 2.42 1.83 −0.31 1.22 0.44 1.67 7411.43 0.01 1.55 0.14 0.43 −0.19 0.73 0.61 0.99 0.83 0.88 0.39 0.75 235681.22 −0.32 0.30 −0.88 −0.15 1.16 0.99 1.12 0.79 0.98 1.69 1.16 0.9879144 0.46 0.47 0.81 −0.24 0.16 0.77 1.88 1.68 1.18 1.54 1.28 −0.38−0.60 91319 0.15 1.29 0.46 −0.42 −0.44 0.92 0.20 2.64 −0.29 1.45 1.910.19 0.85 79654 0.36 −1.15 1.05 0.58 0.20 1.06 1.44 1.00 0.38 0.57 2.48−0.53 0.64 115950 0.98 −2.01 0.67 0.83 −0.26 0.33 1.07 0.48 1.16 1.110.89 0.15 1.50 1374 1.44 −1.60 1.16 0.66 0.87 0.43 1.77 0.21 −0.73 0.372.11 1.09 1.00 81533 0.46 −0.86 0.92 0.52 0.43 1.00 −0.07 0.63 0.37 1.910.63 0.03 1.80 201931 −0.82 −2.06 −0.53 0.31 −0.18 2.23 1.04 1.20 0.531.56 1.34 0.23 0.69 7979 0.73 −1.07 0.61 0.16 −0.93 0.91 0.91 1.92 0.991.14 0.74 0.36 0.72 159296 −0.20 0.57 1.82 −0.28 −0.20 0.96 1.31 −0.111.55 0.42 −0.02 0.07 1.47 51102 0.04 −0.44 0.71 −0.09 −0.58 1.10 0.341.23 1.17 0.60 2.12 0.26 1.67 8729 −1.28 0.35 0.14 0.64 0.31 1.47 0.101.60 0.65 0.89 1.14 0.80 0.37 118460 −0.58 −0.27 −0.35 0.30 −0.12 1.271.31 0.60 1.80 0.06 2.06 0.33 0.56 79586 0.24 −0.60 −1.04 0.71 −0.820.39 0.20 2.85 1.40 1.12 0.23 0.71 1.54 2052 1.11 −0.86 2.09 0.72 0.281.09 0.47 1.12 0.36 1.57 0.82 0.19 0.90 84893 −0.01 −0.98 2.23 0.80−0.29 0.24 0.32 1.65 0.78 0.83 0.44 0.61 1.43 54726 0.36 −2.67 1.55 0.711.09 1.10 0.96 1.20 0.32 −0.03 0.73 0.08 1.29 813 0.26 −1.77 0.48 −0.37−0.09 2.63 0.58 1.67 0.30 1.18 1.13 0.50 1.34 54431 −0.41 −1.83 1.240.87 −0.15 1.57 −0.13 1.61 0.61 0.78 1.91 −0.13 1.95 9612 −0.10 0.090.14 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51380 −0.27 −0.09 −0.14 0.061.55 −1.54 −0.38 −1.37 −1.24 −1.69 −1.78 0.90 −1.71 10289 0.70 0.21 0.460.08 0.41 −0.51 −0.02 −0.29 −1.10 −1.16 −0.63 −0.81 −0.43 10296 0.57−2.49 −0.23 0.10 1.41 −1.69 0.09 −0.72 −1.92 −1.38 −0.70 −0.29 −1.12114224 1.01 −2.13 0.84 −0.01 1.21 −0.48 −1.25 −1.88 −1.10 −0.21 −1.290.11 −2.10 2153 −1.29 0.22 −0.50 −0.01 1.46 −1.68 −0.34 −1.54 −0.84−0.80 −1.89 0.71 −1.23 55825 −1.39 1.16 −1.50 0.14 0.50 −1.38 −0.96−1.34 −0.69 −0.12 −1.71 −0.01 −0.95 6503 −0.44 −0.09 −0.92 0.16 1.22−2.09 0.47 −1.85 0.18 −0.46 −1.63 0.31 −1.76 7913 0.15 −1.37 1.58 0.400.13 −1.63 0.91 −0.68 −0.60 −1.29 −0.28 −1.34 −1.48 30834 1.04 −1.30−0.83 −0.48 0.06 −1.36 −0.55 0.30 −2.11 −0.36 −0.68 −1.02 −0.18 26999−1.11 0.10 −0.79 −0.07 −0.13 −2.15 −0.90 −0.81 −0.06 −1.87 0.74 −0.38−0.59 286437 −1.27 −0.01 −1.52 0.19 0.46 −1.54 −1.44 −0.75 −0.03 −0.47−1.27 0.36 −0.61 4277 −1.44 0.62 −1.13 0.56 0.54 −1.42 −0.74 −0.78 −1.71−0.92 −0.51 −0.43 0.06 5698 −0.74 −0.24 −2.61 −0.38 −0.29 −1.17 −0.56−0.36 −0.77 0.95 −0.86 −0.57 −0.11 4318 −0.23 1.00 0.27 −0.31 1.28 −1.31−0.21 −1.42 −0.85 −0.67 −2.52 0.23 −0.94 10616 0.00 −0.64 −0.41 0.261.27 −2.22 0.34 −1.99 −1.68 −1.40 −1.02 −0.42 −0.76 23012 −1.49 0.02−1.09 0.19 0.86 −1.70 −0.05 −1.23 −1.13 −1.30 −0.69 0.13 −0.95 100129361−0.01 0.92 0.17 −0.23 −0.04 −1.34 0.07 −2.27 −0.84 −1.20 −1.04 −0.25−0.24 10742 −0.44 1.06 −0.25 −0.59 0.49 −1.56 −1.22 −1.14 −0.12 −1.02−1.37 −0.42 −0.51 196264 −0.69 −0.50 −1.07 0.00 1.02 −1.32 −0.48 −1.80−0.41 −0.64 −1.82 0.63 −0.78 27197 −1.16 −0.23 −1.77 0.46 0.82 −1.730.57 −1.82 −0.67 −0.18 −1.45 −0.35 −0.68 7529 −0.63 −0.57 −0.75 −0.060.72 −0.99 0.33 −1.52 −0.06 0.35 −1.67 −0.38 −1.73 94235 −0.82 −0.23−0.73 0.29 0.22 −0.97 −0.62 −0.56 −0.99 −0.15 −1.35 0.41 −1.24 352961−1.67 0.70 −1.42 −0.25 −0.11 −1.35 −2.01 −0.19 −0.28 0.23 −0.23 −0.65−1.23 49856 −0.78 −0.95 −1.29 0.12 1.13 −1.50 0.37 −0.93 −0.90 −1.08−2.01 0.19 −0.77 9448 −0.59 −0.35 0.04 0.68 1.15 −2.04 −0.12 −1.91 −0.40−1.10 −1.66 0.12 −1.12 9525 −1.02 −0.95 −1.20 0.70 0.48 −1.00 −0.15−0.43 −0.62 −1.54 −0.17 −1.44 −0.08 100505576 −0.20 1.06 −0.59 0.47 1.10−1.72 −0.75 −0.39 −0.39 −2.04 −1.16 −0.01 −1.34 151556 −1.59 −0.55 −1.770.02 0.50 −1.78 −0.89 −0.59 −0.56 −0.09 −1.22 0.53 −0.98 284613 0.910.39 −0.85 −0.12 0.97 −2.62 −0.18 −0.51 −0.35 −0.17 −2.08 −0.40 −1.31286223 −0.48 0.97 −0.62 0.21 0.71 −0.77 −0.45 −1.48 −1.30 0.34 −2.48−0.60 −0.58 57061 1.15 0.29 0.43 −0.06 0.34 −1.58 −1.46 −0.71 −0.12−0.65 −1.03 −0.97 −1.63 9520 −0.82 −1.10 −0.44 0.24 1.34 −0.81 0.12−2.17 −1.52 −0.54 −1.61 0.38 −0.92 202299 0.02 1.74 −0.68 −0.85 −0.39−0.23 −1.28 −0.44 −0.75 0.44 −1.28 −1.92 0.19 2015 −0.20 −0.94 0.30−0.01 1.19 −2.03 0.02 −2.16 −0.53 −1.57 −1.09 0.30 −0.51 57763 −1.70−1.43 −0.82 0.78 −0.05 −0.21 −0.99 0.70 −1.42 −0.84 0.16 −0.67 −0.4054778 −1.92 −0.72 −0.97 0.80 1.12 −0.70 0.23 −0.85 −1.81 −0.24 −1.06−0.22 −0.91 762 0.07 0.13 −0.68 −0.21 1.50 −0.79 −0.07 −1.15 −1.51 −0.94−2.12 0.33 −1.40 192668 0.07 0.31 −0.07 0.20 −0.21 −1.54 −0.90 −1.060.13 −0.71 −2.03 0.03 −0.05 24146 0.57 −0.18 1.72 0.41 0.85 −1.60 −0.24−1.45 −0.07 −0.51 −2.01 −1.50 −1.37 54843 −1.38 −1.01 −1.25 0.18 −0.75−0.04 −1.66 −0.28 −0.58 1.24 0.13 −0.37 −0.93 55374 −0.83 0.19 −1.370.42 0.91 −1.48 −0.88 −0.97 −0.16 0.36 −1.93 −0.18 −1.23 79603 −0.73−0.21 −0.90 0.12 −0.61 −1.48 −0.26 −0.66 −0.63 −0.38 −1.90 −0.01 −0.323577 −0.04 0.43 −0.27 0.43 1.29 −1.93 −0.32 −1.75 −1.66 −0.23 −1.89−0.08 −1.31 10385 −1.49 0.56 −1.86 −0.62 −0.12 −0.69 −1.36 −1.25 0.440.16 −0.50 −0.48 −0.10 79792 1.85 0.17 1.00 −0.35 −0.52 −2.17 0.45 −0.87−1.13 −0.69 −1.75 −0.79 −0.88 84674 −0.39 0.05 −0.19 0.34 1.37 −1.700.42 −2.50 −1.07 −0.34 −2.10 −0.21 −1.12 51131 −0.38 0.81 −0.74 −0.55−0.13 −0.73 −0.79 −0.86 −0.73 0.52 0.05 −1.42 −0.95 5966 −1.03 −0.680.41 −0.67 0.93 −0.94 0.69 −1.60 −0.40 −0.69 0.27 −0.70 −1.64 9733 −1.84−2.27 −1.93 0.44 −0.36 −0.14 0.08 −0.14 −0.95 0.00 −0.16 −0.46 −0.1210328 −0.84 −0.29 0.70 −1.49 −0.78 −0.56 −0.38 −0.75 −2.76 0.90 −1.61−0.76 0.54 255231 −1.14 1.95 −1.46 −0.26 −0.20 −0.85 −1.39 −0.57 0.18−0.52 −1.59 −0.56 −1.02 25801 −0.06 0.10 −0.23 0.59 1.47 −1.92 0.28−1.92 −1.40 −0.67 −1.50 −0.35 −1.36 6352 −1.13 −0.16 −1.00 0.05 −0.07−1.25 −0.09 −1.39 −0.26 0.33 0.52 −0.51 −1.62 54811 1.20 2.25 −1.15−0.23 −0.50 −0.68 −0.11 −1.60 −1.46 −0.18 −1.10 −0.54 −0.62 59348 0.55−0.83 −0.28 −0.22 1.63 −1.49 −0.35 −0.93 −0.55 −2.61 −1.32 0.26 −0.619967 −0.31 −0.87 −0.25 0.01 0.70 −0.70 0.62 −2.98 −1.66 −0.15 −1.91 0.73−1.22 2533 −0.40 −0.87 −0.40 0.06 1.06 −2.02 0.17 −1.55 −0.84 −0.88−1.34 0.27 −1.79 28985 −1.57 −0.57 −0.96 −0.69 0.21 −0.17 −0.96 0.87−1.37 0.61 −0.33 −1.51 −0.31 55234 −1.39 −2.16 −1.95 0.25 0.29 −0.42−0.78 −0.59 −0.55 −1.61 −0.87 0.97 −0.28 1301 −0.13 1.76 −1.45 −0.27−0.05 −1.79 −1.32 −0.94 0.75 −0.96 −1.31 −0.01 −0.94 84803 −0.92 −0.99−1.14 −0.01 1.86 −0.86 0.07 −1.55 −0.99 −0.15 −1.58 0.12 −1.23 1005067790.11 −0.93 0.03 −0.08 −0.09 −1.76 −0.13 −0.93 −0.30 −2.04 0.68 −1.88−1.36 197135 −0.71 −1.13 −0.76 0.19 0.09 −0.76 −1.29 −1.80 0.64 −0.31−0.37 −0.89 −1.55 3614 0.41 −0.03 −0.14 0.07 1.18 −2.13 0.07 −1.98 −0.72−0.93 −1.80 −0.74 −1.13 80781 −0.36 1.09 0.29 0.23 0.48 −2.93 −0.38−1.04 −0.37 −0.56 −1.58 0.24 −0.97 5586 −0.31 −0.29 0.73 1.12 0.96 −0.76−0.58 −0.99 −1.76 −0.22 −1.49 −0.10 −1.25 79415 −0.20 1.48 −1.49 0.250.88 −1.73 −0.49 −1.76 −0.33 −0.83 −2.30 0.17 −1.22 8893 −0.65 −0.390.08 0.31 0.39 −1.42 −0.96 −0.56 0.04 −1.19 −0.43 −1.52 0.22 79736 −1.143.19 −1.06 0.01 −0.12 −0.70 −0.69 0.46 −1.94 0.18 −1.26 −0.34 −0.43 5770−1.06 2.10 −1.28 −1.53 0.49 0.56 −1.06 −0.82 −1.28 −0.47 −2.00 0.18−0.38 9360 −0.68 −2.03 −0.70 0.86 0.70 −0.97 −0.23 −0.08 −0.90 −2.21−1.17 1.25 −1.04 29940 −0.62 −0.15 −1.11 −0.67 1.04 −1.20 0.40 −2.00−0.83 −0.01 −1.81 −0.31 −0.37 7150 1.30 −0.27 1.04 −0.87 0.47 −0.47−1.72 −0.75 −0.91 0.28 −1.96 −0.92 −1.33 84964 −1.20 −1.09 −0.79 0.00−0.12 −1.18 −1.16 −0.27 −0.20 −1.63 −0.65 −0.37 −0.76 10614 0.54 −0.15−0.65 0.38 0.47 −0.81 0.27 −1.58 −1.76 −0.81 −1.05 −0.18 −0.73 147923−1.74 −0.94 −1.51 0.60 −0.09 −1.63 −0.55 0.36 −0.63 −0.38 0.39 −1.120.25 284029 −1.11 −0.39 −1.60 0.16 0.48 −1.30 −0.09 −0.50 −0.76 −1.67−1.15 0.35 −0.48 54952 −1.46 1.17 −0.06 −0.13 0.17 −1.51 −0.47 −1.76−0.16 −1.05 −1.15 −0.21 −0.62 57476 0.02 −0.31 0.34 −0.79 0.02 −0.670.11 −1.52 0.28 −1.39 −3.16 −0.48 −0.86 8745 −1.00 2.21 −1.70 0.15 −0.53−1.38 −0.67 0.52 −0.98 −0.15 −0.31 −1.72 −0.57 22928 −1.01 1.46 −1.280.09 1.20 −1.64 0.24 −1.43 −0.05 −1.22 −1.37 −0.81 −0.45 25880 −1.50−0.80 −2.08 −0.40 −1.10 0.01 0.03 −0.25 −1.55 −0.01 −0.60 −0.71 0.0928638 −0.81 −0.39 −0.41 0.46 −0.02 −2.19 −0.98 −0.89 −0.47 −0.37 −0.06−1.20 −1.32 29933 −2.06 −0.25 −0.38 −0.49 0.42 −0.91 0.62 −0.86 −0.39−1.87 −1.08 1.13 −1.16 30009 −0.97 −1.71 −0.78 0.60 −0.43 −1.69 0.15−0.49 −1.41 −0.50 −0.50 0.12 −0.86 3554 −0.65 0.83 −0.21 −0.33 1.37−0.71 −0.41 −1.50 −0.30 −0.57 −2.20 0.41 −0.67 8821 −0.97 −1.09 −1.490.05 −0.07 −1.31 −1.14 −0.75 0.07 −0.20 0.56 −0.75 −0.39 10943 −1.31−1.19 −1.00 −0.44 1.30 −1.21 −0.83 −0.87 −0.80 −1.68 −1.18 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0.98−1.06 −0.27 −1.99 −1.22 −0.61 −1.13 0.19 −1.96 50615 −1.20 1.61 −1.16−0.50 −0.32 −1.31 −0.43 −0.83 0.10 −0.72 −1.50 −0.50 −0.95 221178 −0.17−0.98 −1.13 −0.24 0.81 −1.02 −0.12 −1.30 −0.70 −1.05 −0.99 −0.18 −1.3911104 −1.00 −1.29 0.07 −0.20 0.39 −0.45 −0.69 −0.95 −1.39 −0.74 −0.44−0.90 0.07 1117 −0.37 −0.35 −0.97 0.81 −0.79 −0.82 −1.19 −0.97 −0.89−1.52 −1.55 −0.62 −0.26 374969 0.47 −1.69 −0.62 −0.62 0.37 −1.67 0.07−1.58 −0.60 −0.27 −1.79 −0.36 −0.59 6285 −0.37 −0.57 −0.75 −1.27 −0.47−0.98 −0.60 −1.02 −0.51 0.51 0.26 −1.69 −0.19 387357 −1.81 −0.37 −1.070.36 0.17 −1.84 −0.85 −0.59 0.09 −0.85 −0.32 −0.57 −0.95 2960 −2.33−0.14 −1.93 −0.30 0.30 −0.34 −0.32 0.37 −1.63 0.30 −1.06 −0.21 −0.49100129550 −0.56 −0.87 −0.55 0.51 1.52 −1.52 −0.52 −1.34 −0.69 −0.99−1.72 0.73 −1.33 54520 −0.61 −0.60 −1.14 −0.17 0.93 0.13 −1.33 −0.77−0.86 −1.40 −2.10 0.55 −0.69 10302 −2.51 0.24 −1.32 −0.11 −0.67 −1.51−0.84 −0.30 −1.00 0.64 −1.00 −0.62 −0.01 50939 0.55 1.26 0.53 0.01 −0.91−2.42 −1.58 −1.16 −0.05 −0.93 −0.40 0.13 −0.90 8802 −0.26 −0.40 0.15−0.86 0.56 −0.18 −0.38 −0.80 −0.66 −0.41 −1.01 −1.39 0.16 23332 −0.73−0.60 0.25 0.40 0.05 −1.67 0.15 −0.75 −1.95 −0.31 −0.74 −0.40 −0.16203328 −1.37 0.50 −1.02 −0.79 0.35 −1.87 0.00 −0.97 −0.06 −0.86 −1.48−0.06 −1.23 126231 0.39 −2.26 −1.23 0.00 −0.56 −0.68 −1.32 −1.10 −0.610.39 −0.15 −0.50 −0.74 6993 −0.51 0.41 −1.39 −0.72 1.05 −1.49 −0.91−1.51 −1.17 −0.20 −1.94 0.11 −0.78 58500 −0.54 −0.79 −1.35 0.42 0.53−1.82 −0.65 −0.18 −1.35 −0.15 −2.17 0.21 −1.24 10507 −0.38 −1.18 −1.000.33 0.36 −2.64 −0.26 −0.57 −0.68 −1.26 −1.14 −0.30 −1.26 170482 −0.980.02 −0.07 −0.63 −0.22 −1.15 −0.35 −1.45 −0.35 −0.72 −0.99 −1.52 −0.543004 −0.95 −0.97 −0.91 −0.77 −0.18 −1.88 −0.71 −1.09 −0.30 −1.04 −0.53−0.22 −1.04 64895 −1.67 −0.42 −1.03 0.44 0.98 −1.73 −0.15 −0.71 −0.87−1.84 −0.75 0.61 −1.30 7850 −0.67 1.29 −0.64 0.00 1.32 −1.10 −0.32 −1.90−1.20 −0.47 −2.35 0.09 −1.24 93594 −0.52 −0.18 −1.15 1.02 −0.26 −1.63−0.65 −0.63 −0.60 −0.77 −1.58 −0.53 −0.92 23215 −0.02 −0.02 −1.17 −0.270.75 −0.74 −0.41 −1.26 −0.24 −1.50 −1.71 0.38 −2.86 80196 −1.40 −1.60−1.67 0.19 0.54 −1.47 −0.38 −0.43 −1.78 −0.28 −1.10 −0.15 −0.36 284415−0.02 −0.90 0.30 −0.09 0.39 −1.80 −0.45 −1.49 −1.23 −0.58 −1.27 −0.30−0.93 56882 −0.02 −0.23 −0.45 0.56 1.08 −1.26 0.00 −1.70 −1.27 −0.51−2.48 −0.24 −1.13 6508 −0.25 −1.12 −0.36 −0.53 0.56 −2.53 −0.17 −0.62−0.30 −1.95 −1.06 1.04 −1.00 79663 −0.27 −1.40 −0.24 0.30 1.15 −1.04−0.50 −1.65 −0.67 −0.77 −1.79 −0.15 −1.43 474344 −0.72 −1.37 −2.10 0.050.03 −1.97 −0.13 −1.39 −0.03 −0.36 −0.19 −0.44 −1.05 100505746 −1.28−0.13 −0.74 −0.08 0.88 −1.59 −0.13 −1.86 0.40 −1.70 −1.08 −0.35 −1.671293 −1.17 1.62 −0.54 −0.45 0.44 −1.67 −0.99 −1.27 0.38 −1.26 −1.50−0.17 −0.57 10294 −0.59 −1.32 −0.43 0.01 0.45 −0.06 −0.97 −0.98 −1.82−0.63 −0.48 −0.63 −1.05 3091 −0.70 0.99 0.89 −0.76 0.21 −1.25 0.00 −2.32−0.13 −0.97 −1.08 −0.59 −0.88 79573 −1.41 −0.10 −0.94 0.62 0.43 −0.44−1.60 −0.96 −0.73 −1.13 −0.97 −0.08 −0.50 9208 0.56 −0.76 −0.82 0.460.85 −1.06 0.13 −1.92 −1.27 −1.78 −0.81 0.08 −1.97 29116 −0.27 −2.581.19 0.46 0.32 −0.74 −0.61 −0.90 −0.53 −0.89 −1.47 −0.42 −1.07 92370−1.62 −0.80 −0.74 0.67 0.91 −1.12 −0.78 −0.24 −0.84 −1.53 −1.46 0.25−0.82 9546 0.00 0.07 −0.75 −0.16 0.97 −0.85 −1.10 −2.63 −1.00 −0.08−2.03 −0.36 −1.09 253018 −0.64 −0.72 −0.47 −0.28 1.22 −1.80 −0.80 −1.19−0.64 −0.53 −2.19 0.31 −1.22 10096 −0.79 −0.13 0.15 0.42 1.60 −1.46−0.39 −1.67 −0.94 −2.34 −1.00 −0.52 −1.31 84138 0.84 −1.16 −0.64 0.400.22 −2.19 −0.53 −0.75 −1.75 0.11 −1.27 −1.19 −0.40 8440 −0.60 −0.88−1.96 −0.14 −0.16 −0.66 −0.67 −0.59 −0.68 −0.08 −0.17 −1.75 −1.26 7277−1.39 0.66 −1.25 −0.13 0.96 −1.88 −0.51 −0.40 −0.36 −1.78 −2.08 −0.03−1.07 8269 0.26 −2.71 −2.09 0.21 −0.25 −0.22 −0.46 0.48 −0.52 −0.13−1.15 −0.51 0.06 8807 −0.75 0.15 −1.18 0.04 0.86 −1.98 −0.68 −1.33 −0.87−1.01 −1.47 −0.05 −1.30 1235 −1.09 −0.52 −1.19 −0.47 −0.71 −0.95 −0.92−1.19 −0.36 −0.29 −0.45 −0.48 −0.84 7059 1.44 0.21 0.44 −0.70 0.17 −0.780.31 −2.87 −0.05 −0.46 −0.82 −0.56 −2.14 54971 −0.04 0.35 −1.94 0.120.56 −0.90 −0.97 −1.54 −0.70 −0.60 −2.09 0.10 −0.72 57677 −0.82 1.21−1.02 0.25 1.22 −1.04 −1.24 −0.91 −1.59 −1.39 −1.38 0.08 −1.02 6890−1.12 1.35 −2.35 −0.28 0.60 −1.63 −1.24 −1.25 −0.70 −0.27 −1.54 −0.02−0.33 22944 −0.59 −0.67 −0.86 0.25 1.10 −1.47 −0.52 −0.53 −1.37 −2.18−0.74 −0.02 −0.84 26512 −0.86 −0.50 −0.82 0.25 0.70 −1.38 −0.56 −0.29−0.82 −1.28 −1.37 −0.09 −1.73 92797 −1.34 −0.36 −0.87 0.98 1.14 −1.920.04 −1.62 −1.14 −1.06 −1.18 −0.46 −1.27 5481 0.41 −0.37 −0.66 −0.080.36 −0.38 −0.04 −1.15 −3.10 −0.34 −0.76 −1.56 −0.92 22897 −0.12 −0.91−0.53 −0.46 −0.49 −0.66 −0.50 −1.20 −0.15 −0.12 −0.78 −0.17 −1.82 3620−0.02 0.84 −1.89 −0.16 0.34 −0.54 −0.76 −1.61 −0.41 0.02 −2.38 −0.88−0.33 64766 −0.78 0.05 −0.24 1.04 0.31 −1.50 −0.70 −1.26 −1.77 −1.720.08 −0.33 −1.45 8809 −1.30 −0.28 −1.05 0.20 1.05 −1.61 −0.70 −1.51−0.97 −1.04 −1.44 0.04 −1.06 116984 −1.14 −0.26 −1.85 −0.25 0.54 −1.26−0.93 −0.94 −0.72 −0.79 −0.48 −0.15 −0.90 440823 −1.34 1.31 −1.31 −0.750.29 −1.84 −1.26 −0.78 −0.53 −0.71 −0.46 0.38 −1.74 59340 −0.83 −0.38−2.29 0.82 0.85 −0.82 −0.18 −0.27 −0.82 −1.15 −0.41 −1.10 −1.82 197259−0.21 0.32 −0.72 0.01 1.28 −1.69 −0.61 −2.04 −0.74 −0.70 −1.19 −0.54−1.66 23670 −0.67 −1.12 −0.96 0.44 0.99 −1.40 −0.20 −1.98 −0.94 −1.09−1.23 0.23 −1.20 643314 −0.32 0.34 −0.53 0.57 0.62 −2.15 −1.32 −1.91−0.16 −1.25 −1.16 −0.01 −2.19 28526 −0.33 0.10 −1.60 0.78 −0.68 −2.09−0.85 −0.73 −0.60 −1.17 −0.48 −0.75 −0.92 55096 0.28 −0.35 0.33 −0.780.63 −2.07 −1.96 −1.31 −0.66 −0.55 −1.70 0.36 −1.25 2796 −0.66 −2.900.38 −0.08 −0.04 −2.13 0.07 0.42 −0.22 −0.28 −0.14 −0.85 −1.54 54509−0.80 0.32 −1.43 −1.08 −0.54 −0.76 0.25 −0.90 −1.00 −0.42 −0.88 −0.38−1.12 11120 0.07 −1.63 −0.62 −0.13 0.65 −0.96 −0.54 −1.58 −1.21 −1.08−0.76 0.42 −1.52 84869 −1.53 −0.83 −1.22 0.27 0.12 −0.85 −0.74 −1.13−1.13 0.70 −1.53 −1.57 −0.51 28991 −0.58 −0.24 −1.90 −0.12 1.08 −0.75−0.13 −0.51 −2.03 −0.07 −2.53 −0.10 −0.26 154141 0.00 −2.65 −0.96 0.230.95 −0.25 0.11 −2.56 −0.86 −0.20 −1.10 −0.21 −1.12 3659 −0.18 −0.21−1.33 −0.05 1.12 −2.24 −0.61 −1.14 −1.09 −0.73 −0.41 0.38 −1.25 154007−0.20 −0.06 −0.13 0.34 0.70 −2.02 −0.47 −1.60 −0.35 −1.79 −1.87 0.29−1.08 116835 −1.12 0.68 −1.54 0.24 0.80 −1.18 −0.33 −2.58 −1.03 −0.89−1.03 0.09 −1.15 9488 −1.72 −0.07 −0.55 0.53 0.32 −1.55 0.30 −2.07 −1.93−0.62 −1.05 −0.04 −1.24 100293516 −1.76 −1.15 −0.55 0.34 −0.74 −1.19−0.96 −0.71 −0.49 −1.11 0.00 −0.92 −0.87 9217 −1.39 0.45 −1.31 0.22 0.31−1.69 −0.91 −0.14 −0.47 0.21 −1.60 −0.55 −1.38 10538 −0.20 1.16 −0.96−1.16 0.40 −2.02 −0.61 −1.84 −0.45 −1.32 −1.77 0.27 −1.54 6935 −1.18−0.24 −0.24 −0.04 0.41 −2.43 −0.58 −0.53 −0.58 −3.17 −0.48 0.80 −0.6610443 −0.53 −0.16 −0.41 0.56 0.54 −2.02 −0.84 −1.19 0.30 −1.54 −0.750.00 −1.76 3837 −0.67 −3.06 −0.44 0.00 0.76 −0.97 0.33 −1.43 −0.63 0.10−1.19 −0.47 −0.87 81698 0.15 0.90 −0.22 −0.31 0.27 −1.29 −2.39 −2.450.03 0.43 −1.90 −0.50 −1.09 2643 −1.53 −1.49 −0.47 −0.24 −0.10 −0.92−0.26 −0.91 0.08 −0.70 −1.58 −0.30 −0.27 57559 −1.08 0.72 −0.73 0.38−0.75 −1.66 −1.63 −1.12 −1.00 −1.40 −0.22 −0.50 −0.78 116842 −0.83 −0.27−0.92 −0.42 0.50 −0.31 −1.47 −0.82 −0.86 −1.33 −1.20 0.53 −0.94 202−0.59 0.69 −0.56 −0.53 0.42 −1.52 0.10 −2.24 −0.36 −0.70 −1.94 −0.25−1.80 9934 −0.93 −0.16 −0.92 0.22 0.90 −2.26 0.01 −1.89 −0.72 −0.65−1.42 −0.25 −1.14 100216546 −0.56 −0.82 −0.80 0.04 0.65 −0.82 −2.30−0.93 −0.17 −0.24 −1.64 −0.02 −0.84 9692 0.38 −1.90 −1.18 −0.97 −0.22−0.70 0.15 0.14 −2.01 −0.92 0.28 −0.30 −0.59 89845 0.54 −0.16 −2.42 0.410.04 −0.12 −1.78 −0.04 −0.80 −0.84 −1.59 −0.56 −0.79 26034 −0.98 0.48−1.28 0.09 0.38 −1.26 −0.81 −1.65 −0.45 −1.23 −1.57 −0.25 −1.32 10906−0.61 −0.68 −1.48 0.02 0.72 −1.60 −0.28 −2.06 −1.44 −0.57 −1.66 −0.44−0.41 84811 −1.59 −1.10 −0.68 −0.44 −0.21 −0.77 −1.39 −1.63 −1.12 −0.57−0.80 0.75 −0.03 100527964 0.05 1.04 −0.40 0.00 −0.34 −1.39 −1.20 −0.920.41 −1.88 −0.90 −0.84 −1.32 118426 −1.60 −0.77 −1.09 −0.21 0.73 −1.44−1.03 −1.56 −0.64 −0.62 −1.07 0.54 −1.33 54331 −0.48 0.46 −0.38 0.160.78 −2.96 −0.45 −1.09 −1.12 −1.74 −0.94 −0.35 −1.45 94081 −2.28 1.02−0.14 −0.39 0.15 −2.23 −0.54 −0.65 −0.66 −1.46 −1.12 0.10 −0.57 145474−0.03 −0.28 −0.80 0.23 0.89 −1.38 −1.25 −1.71 −0.39 −1.06 −1.50 −0.67−1.24 84969 −1.53 1.55 −0.78 −0.37 −0.02 −1.42 −1.61 0.04 −1.08 −1.09−1.23 −0.27 −0.35 4907 0.06 −1.19 −0.32 −0.13 −0.29 −0.78 −1.18 −0.57−1.72 −0.69 −1.63 −0.32 −1.49 51735 −1.21 −0.10 −0.94 0.31 0.41 −1.39−0.94 −0.52 −1.20 −1.41 −1.43 −0.01 −0.69 9953 −0.53 −0.67 −0.82 0.270.65 −1.31 −0.71 −0.50 −0.78 −1.37 −1.29 −0.06 −1.19 23112 0.28 −0.77−0.81 0.84 0.47 −1.45 −1.08 −1.48 −0.92 −0.27 −1.72 −0.35 −1.58 91526−1.20 −0.61 −1.21 −0.03 0.86 −1.42 −0.82 −0.96 −0.97 −2.04 −0.91 0.44−1.56 101928017 −0.42 1.09 −0.81 −0.38 −0.52 −1.45 −0.60 −1.46 −0.57−0.22 −1.75 −0.35 −0.22 84859 −1.38 −0.85 −2.06 0.23 0.48 −0.68 −0.84−0.74 −1.35 −0.29 −0.76 0.04 −1.66 159013 −0.49 −1.10 −0.70 −0.08 0.46−1.66 0.47 −1.78 −1.91 −0.81 −0.82 −0.56 −1.14 23208 −0.27 −1.12 −0.69−0.33 −0.57 −1.61 −0.26 −2.00 −0.48 −1.64 −0.96 0.46 −0.34 101928649−0.60 −0.31 −0.38 0.03 −0.07 −1.16 −0.43 −1.38 −1.48 −1.13 −0.90 −0.62−0.67 85459 −0.61 0.37 −0.22 0.15 0.36 −2.16 −1.14 −1.03 −0.96 −1.76−1.59 0.22 −1.32 9617 −0.97 −1.58 −0.41 −0.30 −0.06 −1.36 −1.09 −0.40−0.87 −1.44 −0.19 −1.02 −1.03 56898 −0.03 −0.59 0.11 −0.28 −1.73 −2.44−0.08 −0.40 0.31 −2.06 −0.63 −1.07 −0.16 387882 −0.76 −0.21 −0.74 0.20−0.52 −1.77 −1.07 −0.65 −1.69 0.18 0.42 −1.73 −1.48 677769 0.69 0.61−0.80 −0.90 −0.17 −1.40 −1.81 −0.17 −0.69 −0.97 −1.39 −0.39 −1.39

High level gene sets for deleterious genes (increase with age) andbeneficial genes (decrease with age) were identified, as shown in FIG.2, and as summarized here:

For high level gene sets, the following sets of genes were found to bedeleterious (that is, they increase with age):UNFOLDED_PROTEIN-RESPONSE, OXIDATIVE_PHOSPHORYLATION, MYC_TARGETS_V1,ADIPOGENESIS, GLYCOLYSIS, UV_RESPONSE_UP, DNA_REPAIR,FATTY_ACID_METABOLISM, SPERMATOGENESIS, E2F_TARGETS,BILE_ACID_METABOLISM, MTORC1_SIGNALING, ESTROGEN_RESPONSE_LATE.

The following genes were found to be beneficial (that is, they decreasewith age): APOPTOSIS, APICAL_SURFACE, UV_RESPONSE_DN,EPITHELIAL_MESENCHYMAL_TRANSITION, ANGIOGENESIS, KRAS_SIGNALING_UP,TNFA_SIGNALING_VIA_NFKB, IL2_STAT5_SIGNALING COMPLEMENT,INFLAMMATORY_RESPONSE, INTERFERON_ALPHA_RESPONSE, ALLOGRAFT_REJECTIONAND INTERFERENCE_GAMMA_RESPONSE.

Table 4 summarizes the data from the high level genesets:

TABLE 4 High Level Genesets gs.id gs.desc gs.ngenes fisherzUNFOLDED_PROTEIN_RESPONSE Genes up-regulated during unfolded 109 6.005protein response, a cellular stress response related to the endoplasmicreticulum. OXIDATIVE_PHOSPHORYLATION Genes encoding proteins involved in188 5.683 oxidative phosphorylation. MYC_TARGETS_V1 A subgroup of genesregulated by 179 5.562 MYC - version 1 (v1). HEME_METABOLISM Genesinvolved in metabolism of 197 4.56 heme (a cofactor consisting of ironand porphyrin) and erythroblast differentiation. MYC_TARGETS_V2 Asubgroup of genes regulated by 55 3.473 MYC - version 2 (v2).ADIPOGENESIS Genes up-regulated during adipocyte 196 3.441differentiation (adipogenesis). GLYCOLYSIS Genes encoding proteinsinvolved in 198 3.428 glycolysis and gluconeogenesis. UV_RESPONSE_UPGenes up-regulated in response to 157 3.197 ultraviolet (UV) radiation.DNA_REPAIR Genes involved in DNA repair. 146 2.991 FATTY_ACID_METABOLISMGenes encoding proteins involved in 151 2.425 metabolism of fatty acids.SPERMATOGENESIS Genes up-regulated during production 132 2.34 of malegametes (sperm), as in spermatogenesis. E2F_TARGETS Genes encoding cellcycle related 192 2.266 targets of E2F transcription factors.BILE_ACID_METABOLISM Genes involve in metabolism of bile 111 2.149 acidsand salts. MTORC1_SIGNALING Genes up-regulated through 191 2.144activation of mTORC1 complex. ESTROGEN_RESPONSE_LATE Genes defining lateresponse to 195 2.135 estrogen. APOPTOSIS Genes mediating programmedcell 155 −2.002 death (apoptosis) by activation of caspases.APICAL_SURFACE Genes encoding proteins over- 43 −2.272 represented onthe apical surface of epithelial cells, e.g., important for cellpolarity (apical area). UV_RESPONSE_DN Genes down-regulated in responseto 142 −2.494 ultraviolet (UV) radiation. EPITHELIAL_MESEN- Genesdefining epithelial- 197 −2.866 CHYMAL_TRANSITION mesenchymaltransition, as in wound healing, fibrosis and metastasis. ANGIOGENESISGenes up-regulated during formation 36 −3.103 of blood vessels(angiogenesis). KRAS_SIGNALING_UP Genes up-regulated by KRAS 198 −3.697activation. TNFA_SIGNALING_VIA_NFKB Genes regulated by NF-kB in 199−3.726 response to TNF [GeneID = 7124]. IL2_STAT5_SIGNALING Genesup-regulated by STAT5 in 196 −4.764 response to IL2 stimulation.IL6_JAK_STAT3_SIGNALING Genes up-regulated by IL6 84 −5.798 [GeneID =3569] via STAT3 [GeneID = 6774], e.g., during acute phase response.COMPLEMENT Genes encoding components of the 199 −6.829 complementsystem, which is part of the innate immune system. INFLAMMATORY_RESPONSEGenes defining inflammatory 200 −6.963 response.INTERFERON_ALPHA_RESPONSE Genes up-regulated in response to 94 −7.819alpha interferon proteins. ALLOGRAFT_REJECTION Genes up-regulated duringtransplant 196 −8.52 rejection. INTERFERON_GAMMA_RESPONSE Genesup-regulated in response to 194 −10.885 IFNG [GeneID = 3458].

Table 5 shows GO Biological Processes.

TABLE 5 GO Biological Processes gs.id gs.desc gs.ngenes fisherzGO:0070085 glycosylation 166 5.578 GO:0006487 protein N-linkedglycosylation 90 5.533 GO:0006486 protein glycosylation 164 5.486GO:0043413 macromolecule glycosylation 164 5.486 GO:0018279 proteinN-linked glycosylation via 84 4.97 asparagine GO:0018196peptidyl-asparagine modification 84 4.97 GO:0043687 post-translationalprotein modification 126 4.513 GO:0009101 glycoprotein biosyntheticprocess 193 4.488 GO:0030433 ER-associated protein catabolic process 294.424 GO:0016051 carbohydrate biosynthetic process 148 4.249 GO:0008652cellular amino acid biosynthetic process 87 4.198 GO:0045333 cellularrespiration 120 4.099 GO:0033014 tetrapyrrole biosynthetic process 244.026 GO:0006779 porphyrin biosynthetic process 24 4.026 GO:0006094gluconeogenesis 39 4.011 GO:0006783 heme biosynthetic process 19 3.979GO:0009311 oligosaccharide metabolic process 61 3.866 GO:0006457 proteinfolding 195 3.86 GO:0051289 protein homotetramerization 40 3.789GO:0019319 hexose biosynthetic process 47 3.712 GO:0009086 methioninebiosynthetic process 11 3.628 GO:0009060 aerobic respiration 33 3.628GO:0000097 sulfur amino acid biosynthetic process 14 3.626 GO:0043039tRNA aminoacylation 49 3.592 GO:0043038 amino acid activation 49 3.592GO:0006418 tRNA aminoacylation for protein translation 49 3.592GO:0009067 aspartate family amino acid biosynthetic 17 3.582 processGO:0006084 acetyl-CoA metabolic process 35 3.544 GO:0046148 pigmentbiosynthetic process 43 3.475 GO:0009312 oligosaccharide biosyntheticprocess 42 3.465 GO:0022900 electron transport chain 122 3.425GO:0046395 carboxylic acid catabolic process 148 3.408 GO:0016054organic acid catabolic process 148 3.408 GO:0046364 monosaccharidebiosynthetic process 59 3.363 GO:0048194 Golgi vesicle budding 11 3.306GO:0009309 amine biosynthetic process 122 3.303 GO:0070972 proteinlocalization in endoplasmic 18 3.29 reticulum GO:0042254 ribosomebiogenesis 117 3.267 GO:0022613 ribonucleoprotein complex biogenesis 1903.229 GO:0061136 regulation of proteasomal protein catabolic 50 3.181process GO:0006399 tRNA metabolic process 124 3.157 GO:0006839mitochondrial transport 77 3.144 GO:0006555 methionine metabolic process13 3.107 GO:0046165 alcohol biosynthetic process 80 3.079 GO:0048200Golgi transport vesicle coating 10 3.059 GO:0048205 COPI coating ofGolgi vesicle 10 3.059 GO:0048146 positive regulation of fibroblastproliferation 32 3.048 GO:0006488 dolichol-linked oligosaccharidebiosynthetic 31 3.029 process GO:0009066 aspartate family amino acidmetabolic 34 3.028 process GO:0006829 zinc ion transport 20 3.018GO:0051262 protein tetramerization 63 3.008 GO:0022904 respiratoryelectron transport chain 87 3.007 GO:0006664 glycolipid metabolicprocess 35 2.997 GO:0006099 tricarboxylic acid cycle 22 2.993 GO:0048199vesicle targeting, to, from or within Golgi 21 2.972 GO:0060425 lungmorphogenesis 27 2.963 GO:0009566 fertilization 79 2.939 GO:0016042lipid catabolic process 188 2.931 GO:0007040 lysosome organization 272.926 GO:0046356 acetyl-CoA catabolic process 23 2.917 GO:0034637cellular carbohydrate biosynthetic process 93 2.914 GO:0042559pteridine-containing compound biosynthetic 19 2.897 process GO:0045454cell redox homeostasis 51 2.89 GO:0006900 membrane budding 26 2.887GO:0009064 glutamine family amino acid metabolic 53 2.884 processGO:0042558 pteridine-containing compound metabolic 31 2.87 processGO:0007005 mitochondrion organization 151 2.799 GO:0019438 aromaticcompound biosynthetic process 29 2.797 GO:0050885 neuromuscular processcontrolling balance 35 2.744 GO:0034976 response to endoplasmicreticulum stress 38 2.736 GO:0046685 response to arsenic-containingsubstance 13 2.714 GO:0006901 vesicle coating 25 2.685 GO:0044243multicellular organismal catabolic process 25 2.68 GO:0009310 aminecatabolic process 101 2.665 GO:0006364 rRNA processing 87 2.656GO:0034470 ncRNA processing 188 2.656 GO:0046034 ATP metabolic process125 2.655 GO:0006081 cellular aldehyde metabolic process 34 2.619GO:0042440 pigment metabolic process 51 2.579 GO:0032320 positiveregulation of Ras GTPase activity 79 −2.624 GO:0032675 regulation ofinterleukin-6 production 48 −2.634 GO:0030041 actin filamentpolymerization 12 −2.643 GO:0032651 regulation of interleukin-1 betaproduction 26 −2.65 GO:0042098 T cell proliferation 20 −2.652 GO:0042742defense response to bacterium 101 −2.653 GO:0060491 regulation of cellprojection assembly 36 −2.665 GO:0016064 immunoglobulin mediated immuneresponse 59 −2.671 GO:0007062 sister chromatid cohesion 19 −2.678GO:0001837 epithelial to mesenchymal transition 37 −2.68 GO:0032735positive regulation of interleukin-12 19 −2.682 production GO:0032814regulation of natural killer cell activation 14 −2.684 GO:0046634regulation of alpha-beta T cell activation 45 −2.69 GO:0045580regulation of T cell differentiation 68 −2.695 GO:0045622 regulation ofT-helper cell differentiation 19 −2.701 GO:0045637 regulation of myeloidcell differentiation 97 −2.706 GO:0040017 positive regulation oflocomotion 172 −2.712 GO:0032733 positive regulation of interleukin-1015 −2.721 production GO:0051480 cytosolic calcium ion homeostasis 132−2.725 GO:0070665 positive regulation of leukocyte proliferation 84−2.726 GO:0032946 positive regulation of mononuclear cell 83 −2.731proliferation GO:0040001 establishment of mitotic spindle localization11 −2.737 GO:0043903 regulation of symbiosis, encompassing 17 −2.751mutualism through parasitism GO:0045648 positive regulation oferythrocyte 15 −2.755 differentiation GO:0045070 positive regulation ofviral genome 10 −2.756 replication GO:0050718 positive regulation ofinterleukin-1 beta 13 −2.766 secretion GO:0050716 positive regulation ofinterleukin-1 secretion 13 −2.766 GO:0002275 myeloid cell activationinvolved in immune 19 −2.766 response GO:0002714 positive regulation ofB cell mediated 10 −2.78 immunity GO:0002891 positive regulation ofimmunoglobulin 10 −2.78 mediated immune response GO:0050671 positiveregulation of lymphocyte 82 −2.793 proliferation GO:0019724 B cellmediated immunity 60 −2.796 GO:0045954 positive regulation of naturalkiller cell 13 −2.819 mediated cytotoxicity GO:0002717 positiveregulation of natural killer cell 13 −2.819 mediated immunity GO:0044126regulation of growth of symbiont in host 14 −2.829 GO:0044146 negativeregulation of growth of symbiont 14 −2.829 involved in interaction withhost GO:0044130 negative regulation of growth of symbiont in 14 −2.829host GO:0044144 modulation of growth of symbiont involved 14 −2.829 ininteraction with host GO:0044060 regulation of endocrine process 14−2.834 GO:0032319 regulation of Rho GTPase activity 65 −2.852 GO:0046636negative regulation of alpha-beta T cell 13 −2.852 activation GO:0043901negative regulation of multi-organism 21 −2.856 process GO:0002218activation of innate immune response 113 −2.865 GO:0051653 spindlelocalization 13 −2.871 GO.0051293 establishment of spindle localization13 −2.871 GO:0016197 endosome transport 108 −2.881 GO:0009612 responseto mechanical stimulus 107 −2.911 GO:0032677 regulation of interleukin-8production 31 −2.925 GO:0070661 leukocyte proliferation 39 −2.935GO:0060389 pathway-restricted SMAD protein 10 −2.941 phosphorylationGO:0050706 regulation of interleukin-1 beta secretion 15 −2.942GO:0002274 myeloid leukocyte activation 48 −2.942 GO:0050704 regulationof interleukin-1 secretion 15 −2.942 GO:0045582 positive regulation of Tcell differentiation 44 −2.966 GO:0043547 positive regulation of GTPaseactivity 132 −2.978 GO:0045646 regulation of erythrocyte differentiation23 −2.985 GO:0050715 positive regulation of cytokine secretion 34 −2.999GO:0002286 T cell activation involved in immune 15 −3.021 responseGO:0060323 head morphogenesis 19 −3.03 GO:0002822 regulation of adaptiveimmune response 63 −3.033 based on somatic recombination of immunereceptors built from immunoglobulin superfamily domains GO:0002819regulation of adaptive immune response 66 −3.039 GO:0045785 positiveregulation of cell adhesion 90 −3.039 GO:0045619 regulation oflymphocyte differentiation 81 −3.053 GO:0051607 defense response tovirus 39 −3.064 GO:0030335 positive regulation of cell migration 163−3.068 GO:0032760 positive regulation of tumor necrosis factor 28 −3.07production GO:2000147 positive regulation of cell motility 164 −3.087GO:0032943 mononuclear cell proliferation 38 −3.098 GO:0032647regulation of interferon-alpha production 11 −3.108 GO:0001912 positiveregulation of leukocyte mediated 22 −3.119 cytotoxicity GO:0002366leukocyte activation involved in immune 53 −3.122 response GO:0002263cell activation involved in immune response 53 −3.122 GO:0050707regulation of cytokine secretion 48 −3.123 GO:0032479 regulation of typeI interferon production 48 −3.129 GO:0032680 regulation of tumornecrosis factor 54 −3.135 production GO:0071214 cellular response toabiotic stimulus 95 −3.137 GO:0070663 regulation of leukocyteproliferation 122 −3.169 GO:0042102 positive regulation of T cellproliferation 56 −3.18 GO:0045621 positive regulation of lymphocyte 51−3.181 differentiation GO:0032480 negative regulation of type Iinterferon 30 −3.217 production GO:0007259 JAK-STAT cascade 36 −3.221GO:0045069 regulation of viral genome replication 20 −3.223 GO:0042119neutrophil activation 11 −3.23 GO:0006569 tryptophan catabolic process11 −3.232 GO:0046218 indolalkylamine catabolic process 11 −3.232GO:0042436 indole-containing compound catabolic 11 −3.232 processGO:0007204 elevation of cytosolic calcium ion 117 −3.245 concentrationGO:0032312 regulation of ARF GTPase activity 24 −3.246 GO:0006959humoral immune response 78 −3.258 GO:0051272 positive regulation ofcellular component 173 −3.283 movement GO:0071346 cellular response tointerferon-gamma 73 −3.295 GO:0032653 regulation of interleukin-10production 22 −3.307 GO:0033363 secretory granule organization 10 −3.319GO:0035023 regulation of Rho protein signal transduction 132 −3.344GO:0050853 B cell receptor signaling pathway 19 −3.349 GO:0019835cytolysis 20 −3.366 GO:0045022 early endosome to late endosome transport12 −3.38 GO:0002443 leukocyte mediated immunity 94 −3.383 GO:0042129regulation of T cell proliferation 81 −3.406 GO:0032944 regulation ofmononuclear cell proliferation 119 −3.406 GO:0050856 regulation of Tcell receptor signaling 15 −3.407 pathway GO:0008625 induction ofapoptosis via death domain 14 −3.411 receptors GO:0050727 regulation ofinflammatory response 123 −3.42 GO:0002460 adaptive immune responsebased on somatic 83 −3.433 recombination of immune receptors built fromimmunoglobulin superfamily domains GO:0050670 regulation of lymphocyteproliferation 118 −3.458 GO:0033209 tumor necrosis factor-mediatedsignaling 23 −3.486 pathway GO:0032103 positive regulation of responseto external 111 −3.501 stimulus GO:0045089 positive regulation of innateimmune 138 −3.502 response GO:0006568 tryptophan metabolic process 12−3.522 GO:0042108 positive regulation of cytokine biosynthetic 55 −3.527process GO:0046651 lymphocyte proliferation 36 −3.536 GO:0032318regulation of Ras GTPase activity 119 −3.562 GO:0070670 response tointerleukin-4 12 −3.598 GO:0002250 adaptive immune response 87 −3.66GO:0002697 regulation of immune effector process 161 −3.675 GO:0060333interferon-gamma-mediated signaling 62 −3.711 pathway GO:0002715regulation of natural killer cell mediated 16 −3.715 immunity GO:0042269regulation of natural killer cell mediated 16 −3.715 cytotoxicityGO:0002699 positive regulation of immune effector 74 −3.722 processGO:0045071 negative regulation of viral genome 11 −3.738 replicationGO:0048525 negative regulation of viral reproduction 11 −3.738GO:0002708 positive regulation of lymphocyte mediated 35 −3.741 immunityGO:0002705 positive regulation of leukocyte mediated 35 −3.741 immunityGO:0043122 regulation of I-kappaB kinase/NF-kappaB 144 −3.748 cascadeGO:0031343 positive regulation of cell killing 26 −3.794 GO:0001910regulation of leukocyte mediated 27 −3.795 cytotoxicity GO:0034341response to interferon-gamma 90 −3.815 GO:0032655 regulation ofinterleukin-12 production 32 −3.816 GO:0030811 regulation of nucleotidecatabolic process 199 −3.851 GO:0033121 regulation of purine nucleotidecatabolic 199 −3.851 process GO:0002703 regulation of leukocyte mediatedimmunity 70 −3.862 GO:0050854 regulation of antigen receptor-mediated 17−3.905 signaling pathway GO:0050900 leukocyte migration 169 −4.01GO:0002675 positive regulation of acute inflammatory 20 −4.028 responseGO:0043123 positive regulation of I-kappaB kinase/NF- 132 −4.059 kappaBcascade GO:0002706 regulation of lymphocyte mediated 57 −4.059 immunityGO:0001818 negative regulation of cytokine production 100 −4.164GO:0002407 dendritic cell chemotaxis 13 −4.165 GO:0043087 regulation ofGTPase activity 176 −4.208 GO:0042035 regulation of cytokinebiosynthetic process 84 −4.23 GO:0031341 regulation of cell killing 32−4.238 GO:0033124 regulation of GTP catabolic process 178 −4.291GO:0071260 cellular response to mechanical stimulus 46 −4.33 GO:0001816cytokine production 60 −4.396 GO:0071356 cellular response to tumornecrosis factor 41 −4.406 GO:0034612 response to tumor necrosis factor61 −4.513 GO:0072676 lymphocyte migration 11 −4.521 GO:0002252 immuneeffector process 161 −4.563 GO:0046632 alpha-beta T cell differentiation20 −4.616 GO:0030595 leukocyte chemotaxis 56 −4.649 GO:0060326 cellchemotaxis 71 −4.667 GO:0031349 positive regulation of defense response186 −4.725 GO:0030217 T cell differentiation 71 −4.741 GO:0006968cellular defense response 53 −4.787 GO:0050729 positive regulation ofinflammatory response 57 −4.817 GO:0045088 regulation of innate immuneresponse 185 −4.824 GO:0031295 T cell costimulation 65 −5.003 GO:0031294lymphocyte costimulation 65 −5.003 GO:0030098 lymphocyte differentiation106 −5.066 GO:0046631 alpha-beta T cell activation 26 −5.072 GO:0001819positive regulation of cytokine production 137 −5.304 GO:0071357cellular response to type I interferon 59 −5.319 GO:0060337 type Iinterferon-mediated signaling 59 −5.319 pathway GO:0009615 response tovirus 162 −5.352 GO:0002521 leukocyte differentiation 141 −5.391GO:0034340 response to type I interferon 60 −5.511 GO:0050852 T cellreceptor signaling pathway 74 −6.248 GO:0051251 positive regulation oflymphocyte activation 180 −6.311 GO:0019221 cytokine-mediated signalingpathway 188 −6.417 GO:0042110 T cell activation 130 −6.458 GO:0002696positive regulation of leukocyte activation 194 −6.505 GO:0050867positive regulation of cell activation 200 −6.557 GO:0050870 positiveregulation of T cell activation 146 −6.662 GO:0050851 antigenreceptor-mediated signaling pathway 92 −6.764 GO:0050863 regulation of Tcell activation 193 −6.787 GO:0002757 immune response-activating signal175 −6.928 transduction GO:0002764 immune response-regulating signaling178 −6.938 pathway GO:0002768 immune response-regulating cell surface100 −7.307 receptor signaling pathway GO:0002429 immuneresponse-activating cell surface 98 −7.32 receptor signaling pathway

Table 6 shows MeSH Anatomical Contexts.

TABLE 6 MeSH Anatomical Contexts gs.id gs.desc gs.ngenes fisherzA11.284.430.214.190.875.811 ribosomes 134 3.695 A11.118.290 erythrocytes111 3.469 A11.284.430.214.190.875.190.550 lysosomes 114 3.012A11.284.430.214.190.875.336 golgi_apparatus 183 3.011 A11.118.290.270erythrocyte_membrane 34 2.932 A11.284.430.106.279.345.175 cell_nucleolus151 2.897 A11.443 erythroid_cells 157 2.822 A06.407.071 adrenal_glands26 2.787 A11.284.187.520.300.505.757 chromosomes_human_y 22 2.778A11.284.187.865 sex_chromosomes 191 2.769A11.284.430.214.190.875.117.570 micronuclei_chromosome-defective 132.675 A11.284.835.626.461 mitochondria_liver 29 2.641 A10.272.491endothelium 139 −2.555 A11.284.180.700 pseudopodia 40 −2.672A15.145.229.637.555.567.650 lymphocytes_tumor-infiltrating 11 −2.723A02.835.583 joints 56 −2.735 A11.284.187.520.300.370.375chromosomes_human_pair_13 78 −2.794 A11.284.187.520.300.370chromosomes_human_13-15 191 −2.882 A15.382.520.604.750 thymus_gland 28−3.166 A11.284.187.520.300.325.330 chromosomes_human_pair_6 161 −3.337A15.378.316.340 granulocytes 22 −3.725 A15.145.229.637.415.345eosinophils 42 −4.039 A15.382.680.397 macrophages 135 −4.173A11.118.637.555.567.569.200.400.905 th2_cells 42 −4.25A11.284.149.165.570 membrane_microdomains 61 −4.286A15.382.490.555.567.569.200.700 t-lymphocytes_regulatory 30 −4.303A15.145.229.188 blood_platelets 100 −4.352 A11.329.372 macrophages 171−4.359 A15.382.520 lymphatic_system 96 −4.44 A15.382.032antibody-producing_cells 131 −4.67 A15.382.520.604 lymphoid_tissue 86−4.791 A11.118.637.555.567.569.200.400.900 th1_cells 35 −5.106A15.145.229.637.555.567.569.220.200 t-lymphocytes_cytotoxic 38 −5.175A11.627.624 monocytes 142 −5.806 A15.382.066.270 dendritic_cells 115−5.827 A11.118.637.555.567.537 killer_cells_natural 95 −5.966A15.378.316.580 monocytes 117 −6.038 A15.382.490.555.567.569.200.400t-lymphocytes_helper-inducer 68 −6.297 A11.066 antigen-presenting_cells127 −6.61 A15.382.490.315.583 neutrophils 86 −6.829 A11.627.340granulocytes 158 −7.124 A11.118.637.555.567.569.500 t-lymphocyte_subsets57 −7.292 A15.382.490.555.567.569.440 jurkat_cells 180 −7.396A15.145.229.637.555.567.550 lymphocyte_subsets 81 −7.646A15.145.229.637.415 granulocytes 140 −7.65 A11.118.637.555.567.569.220cd8-positive_t-lymphocytes 90 −7.728 A11.118.637.555.567.569.200cd4-positive_t-lymphocytes 150 −8.198

Table 7 shows chemical genetic perturbations.

TABLE 7 Chemical Genetic Perturbations gs.id gs.desc gs.ngenes fisherzWELCSH_BRCA1_TARGETS_DN Down-regulated by induction of exogenous 1356.537 BRCA1 in EcR-293 cells TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_UP Genesup-regulated in plasma cells compared with 77 6.053 B lymphocytes.YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 Genes co-regulated inuterus during a time course response to progesterone 175 6.038 [PubChem= 5994]: SOM cluster 17. SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYCCluster 2: genes up-regulated in B493-6 cells (B lymphocytes) by serum103 5.872 alone or in combination with MYC [GeneID = 4609] but not byMYC alone. GRUETZMANN_PANCREATIC_CANCER_DN Genes down-regulated inpancreatic ductal adenocarcinoma (PDAC) 192 5.84 identified in a metaanalysis across four independent studies.TIEN_INTESTINE_PROBIOTICS_24HR_DN Genes down-regulated in Caco-2 cells(intestinal epithelium) after coculture 197 5.404 with the probioticbacteria L. casei for 24 h. SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_UPCluster 5: genes up-regulated in B493-6 cells (B lymphocytes) by MYC 455.36 [GeneID = 4609] alone or in combination with serum but not by serumalone. ELVIDGE_HYPDXIA_DN Genes down-regulated in MCF7 cells (breastcancer) under hypoxia conditions. 143 4.834YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 Genes co-regulated inuterus during a time course 137 4.817 response to progesterone [PubChem= 5994]: SOM cluster 14.YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_11 Genes co-regulated inuterus during a time course 100 4.763 response to progesterone [PubChem= 5994]: SOM cluster 11. JIANG_AGING_HYPOTHALAMUS_DN Down-regulated inthe hypothalamus of aged (22 39 4.74 months) BALB/c mice, compared toyoung (2 months) controls LIN_APC_TARGETS Genes up-regulated by forcedexpression of APC 76 4.631 [GeneID = 324] in the APC-deficient SW480cell line (colon cancer). PENG_LEUCINE_DEPRIVATION_DN Genesdown-regulated in BJAB cells (B- 176 4.446 lymphoma) after leucine[PubChem = 857] deprivation. CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DNMarker genes down-regulated in the ‘unannotated’ 186 4.441 subclass ofhepatocellular carcinoma (HCC) samples.PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN Genes down-regulated in HEK-293cells (fibroblast) upon knockdown 168 4.261 of both CTBP1 and SATB1[GeneID = 1487, 6304] by RNAi.SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE IRF4 [GeneID =3662] target genes up-regulated in 94 4.132 primary myeloma vs. mature Blymphocytes. MENSSEN_MYC_TARGETS Genes up-regulated by adenoviralexpression of c-MYC [GeneID = 4609] 49 4.121 in HUVEC cells (umbilicalvein endothelium). HOFMANN_MYELODYSPLASTIC_SYNDROM_RISK_UP Genesup-regulated in bone marrow hematopoietic stem cells 21 4.077 (HSC,CD34+[GeneID = 947]) from patients with high risk of myelodysplasticsyndrome (MDS) compared tothe low risk patients.BARRIER_COLON_CANCER_RECURRENCE_DN Down-regulated genes from the 70-geneprognosis predictor for 19 4.048 stage 2 colon cancer, based onnon-neoplastic mucosa gene expression profiles.CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN Genes down-regulated by2-methoxyestradiol 93 3.989 (2ME2) [PubChem = 1573] in the MM.1S cellline (multiple myeloma) sensitive to dexamethasone [PubChem = 5743].MORI_PLASMA_CELL_UP Up-regulated genes in the B lymphocyte developmentalsignature, based 50 3.979 on expression profiling of lymphomas from theEmu-myc transgenic mice: plasma cell. JOHNSTONE_PARVB_TARGE_TS_2_UPGenes up-regulated upon overexpression of PARVB [GeneID = 29780] 1323.97 in MDA-MB-231 cells (breast cancer) cultured in 3D collagen I and3D Matrigel only. PRAMOONJAGO_SOX4_TARGETS_DN Genes down-regulated inACC3 cells (adenoid cystic carcinoma) after 48 3.959 knockdown of SOX4[GeneID = 6659] by RNAi. SCHUHMACHER_MYC_TARGETS_UP Genes up-regulatedin P493-6 cells (Burkitt's 74 3.947 lymphoma) induced to express MYC[GeneID = 4609]. SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN Cluster 6:genes down-regulated in B493-6 cells 44 3.925 (B lymphocytes) by MYC[GeneID = 4609] in combination with serum but not affected by serumalone; they are also up-regulated by MYC alone.CREIGHTON_AKT1_SIGNALING_VIA_MTOR_UP Genes in the AKT1 [GeneID = 207]pathway which 34 3.89 are independent of MTOR [GeneID = 2475],insensitive to RAD001 (everolimus) [PubChem = 6442177].NIKOLSKY_BREAST_CANCER_16P13_AMPLICON Genes within amplicon 16p13identified in a study 110 3.832 of 191 breast tumor samples.PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_UP Antigen processing andpresentation genes up- 63 3.823 regulated in JY cells (B lymphocytes)treated with TSA [PubChem = 5562]. VALK_AML_CLUSTER_7 Top 40 genes fromcluster 7 of acute myeloid 27 3.775 leukemia (AML) expression profile;61% of the samples are FAB M1 or M2 subtype.DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_UP Genes exclusively up-regulated infibroblasts 61 3.769 expressing the TTD mutant form of ERCC3 [GeneID =2071], after UVC irradiation. SANSOM_APC_TARGETS_REQUIRE_MYC Genesup-regulated after Cre-lox knockout of 197 3.65 APC [GeneID = 324] inthe small intestine that require functional MYC [GeneID = 4609].BURTON_ADIPOGENESIS_5 Up-regulated at 48-96 h during differentiation of120 3.641 3T3-L1 cells (fibroblast) into adipocytes.DAZARD_UV_RESPONSE_CLUSTER_G5 Cluster G5: genes up-regulated in NHEKcells 11 3.638 (normal keratinocyte) at 3 h and 24 h time points afterUV-B irradiation. JIANG_AGING_CEREBRAL_CORTEX_DN Down-regulated in thecerebral cortex of aged (22 52 3.618 months) BALB/c mice, compared toyoung (2 months) controls LI_AMPLIFIED_IN_LUNG_CANCER Genes withincreased copy number that correlates 151 3.578 with increasedexpression across six different lung adenocarcinoma cell lines.LUI_THYROID_CANCER_PAX8_PPARG_DN Top down-regulated genes distinguishingbetween follicular thyroid carcinoma 36 3.554 (FTC) samples by thepresence or absence of the PAX8-PPARG [GeneID = 7849; 5468] fusionprotein. VALK_AML_WITH_FLT3_ITD Genes that best predicted acute myeloidleukemia (AML) with internal tandem 35 3.538 duplications (IDT) in FLT3[GeneID = 2322]. WOO_LIVER_CANCER_RECURRENCE_DN Genes negativelycorrelated with recurrence free survival in patients with 77 3.529hepatitis B-related (HBV) hepatocellular carcinoma (HCC).MORI_LARGE_PRE_BII_LYMPHOCYTE_UP Up-regulated genes in the B lymphocyte80 3.485 developmental signature, based on expression profiling oflymphomas from the Emu-myc transgenic mice: the Large Pre-BII stage.JAIN_NFKB_SIGNALING Genes abnormally regulated in response to CD40L 733.481 and IL4 [GeneID = 959; 3565] stimulation of B lymphocytes frompatients with a hypomorphic mutation of IKBKG [GeneID = 8517].GUTIERREZ_MULTIPLE_MYELOMA_DN Genes exclusively down-regulated in plasmacells 32 3.481 from MM (multiple myeloma) patients but with a similarexpression pattern in the normal cells and in the cells from WM(Waldenstroem's macroblobulinemia) patients.FALVELLA_SMOKERS_WITH_LUNG_CANCER Genes that distinguish normal fromcancer (lung 76 3.474 adenocarcinoma) samples and smokers from nonsmoking subjects. - ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLASTProteins secreted in co-culture of LKR-13 tumor 125 3.466 cells(non-small cell lung cancer, NSCLC) and MLg stroma cells (fibroblasts).JIANG_VHL_TARGETS Genes up-regulated in 786-0 cells (renal 126 3.408carcinoma, RCC) upon expression of VHL [GeneID = 7428] off a retroviralvector under normoxia (normal oxygen) condition.MCCLUNG_DELTA_FOSB_TARGETS_8WK Genes up-regulated in the nucleusaccumbens (a major reward center in 46 3.327 brain) 8 weeks afterinduction of deltaFosB, a FOSB [GeneID = 2354] splice variant.JIANG_TIP30_TARGETS_DN Down-regulated genes in HepG2 cells (liver 223.262 cancer) overexpressing an oncogenic variant of tumor suppressorTIP30 [GeneID = 10553] compared to its wild type form.LI_DCP2_BOUND_MRNA Genes encoding mRNA transcripts specifically 84 3.245bound by DCP2 [GeneID = 167227]. MODY_HIPPOCAMPUS_POSTNATAL Genesup-regulated in hyppocampus at late 61 3.24 postnatal stages (clusters11 and 15). ZHAN_LATE_DIFFERENTIATION_GENES_UP B lymphocyte latedifferentiation genes (LDG): 32 3.22 top genes up-regulated in plasmacells from tonsils (TPC) compared to those from bone marrow (BPC).WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_WITH_H4K20ME1_MARK Genes withpromoters bound by both PPARG and 138 3.213 RXRA [GeneID = 5468, 6256]at 8 (but not 0) day time point of adipocyte differentiation of 3T3-L1cells (preadipocyte) and that were newly modified by H4K20me1.SCHLOSSER_MYC_AND_SERUM_RESPONSE_SYNERGY Cluster 3: genes stronglyup-regulated in B493-6 30 3.178 cells (B lymphocytes) by a combinationof MYC [GeneID = 4609] and serum but not by each of them alone.ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_UP Genes up-regulated inK562 cells (lymphoblast) 82 3.167 by MYC [GeneID = 4609] in the presenceof CKN1B [GeneID = 1027]. SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_UP Top 50up-regulated markers distinguishing 40 3.166 diffuse large B-celllymphoma (DLBCL) from follicular lymphoma (FL) samples.DAZARD_UV_RESPONSE_CLUSTER_G4 Cluster G4: genes increasinglyup-regulated in 20 3.164 NHEK cells (normal keratinocyte) after 12 htime point after UV-B irradiation. NIKOLSKY_BREAST_CANCER_7P15_AMPLICONGenes within amplicon 7p15 identified in a copy 10 3.162 numberalterations study of 191 breast tumor samples. MCCLUNG_COCAINE_REWARD_5DGenes up-regulated in the nucleus accumbens (a major reward center inthe brain) 78 3.156 after 5 days of cocaine [PubChem = 5760] treatment.MOOTHA_FFA_OXYDATION Genes involved in free fatty acid oxidation; based21 3.09 on literature and sequence annotation resources and coverted toAffymetrix HG-U133A probe sets. AMIT_SERUM_RESPONSE_40_MCF10A Geneswhose expression peaked at 40 min after 32 3.088 stimulation of MCF10Acells with serum. WELCH_GATA1_TARGETS Genes up-regulated after GATA1[GeneID = 2623] 20 3.072 activation in G1E-ER4 cells (erythroidprecursors engineered to express GATA1 upon addition of estradiol[PubChemID = 5757]). SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM Cluster 7:genes up-regulated in B493-6 cells (B 156 3.069 lymphocytes) by MYC[GeneID = 4609] and down-regulated by the combination of MYC and serum.WALLACE_PROSTATE_CANCER_UP Genes up-regulated in prostate tumor vsnormal 19 3.065 tissue samples. MOOTHA_VOXPHOS Genes involved inoxidative phosphorylation; 81 3.053 based on literature and sequenceannotation resources and converted to Affymetrix HG-U133A probe sets.ZHANG_RESPONSE_TO_CANTHARIDIN_DN Genes down-regulated in HL-60 cells(promyeloid 62 3.052 leukemia) by cantharidin [PubChem = 6708701].POMEROY_MEDULLOBLASTOMA_PROGNOSIS_DN Top marker genes in medulloblastomaassociated 35 3.052 with poor response to treatment (poor outcome).KIM_GASTRIC_CANCER_CHEMOSENSITIVITY Genes up-regulated in gastric cancerpatients 101 3.033 refractory to chemotherapy treatment with 5-fluorouracil and cisplatin [PubChem = 3385; 2767] compared to thesensitive state. OXFORD_RALA_OR_RALB_TARGETS_UP Genes up-regulated afterknockdown of RALA or 46 3.013 RALB [GeneiD = 5898; 5899], which werealso differentially expressed in bladder cancer compared to normalbladder urothelium tissue. SESTO_RESPONSE_TO_UV_C6 Cluster 6: geneschanged in primary keratinocytes 33 3.006 by UVB irradiation.NAKAMURA_CANCER_MICROENVIRONMENT_DN Genes down-regulated in pancreaticcancer cells 45 3.005 grown in orthotopic xenograft tumors compared tothose grown in vitro. BILANGES_RAPAMYCIN_SENSITIVE_VIA_TSC1_AND_TSC2Genes translationally repressed by rapamycin 63 3 (sirolimus) [PubChemID= 6610346] in MEF cells (embryonic fibroblast) lacking either TSC1 orTSC2 [GeneID = 7248, 7249] but not in the wild type cells.KAYO_CALORIE_RESTRICTION_MUSCLE_DN Downregulated in the vastus lateralismuscle of middle aged rhesus monkeys 80 2.996 subjected to caloricrestriction since young adulthood vs age matched controlsSHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE IRF4 [GeneID= 3662] target genes up-regulated in 62 2.992 plasma cells compared tomature B lymphocytes. LUI_TARGETS_OF_PAX8_PPARG_FUSION Genesdown-regulated in follicular thyroid 26 2.949 carcinoma (FTC) samplesthat bear PAX8-PPARG [GeneID = 7849; 5468] fusion protein.YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_12 Genes co-regulated inuterus during a time course 76 2.949 response to progesterone [PubChem =5994]: SOM cluster 12. RHODES_CANCER_META_SIGNATURE Genes commonlyup-regulated in cancer relative 58 2.948 to normal tissue, according tothe meta-analysis of the OncoMine gene expression database.QI_PLASMACYTOMA_DN Down-regulated genes that best discriminate 98 2.922plasmablastic plasmacytoma from plasmacytic plasmacytoma tumors.HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP Genes up-regulated duringdifferentiation from 157 2.899 large pre-BII to small pre-BIIlymphocyte. FAELT_B_CLL_WITH_VH3_21_UP Genes up-regulated in samplesfrom B-CLL (B- 42 2.895 cell chronic lymphocytic leukemia) with theimmunoglobulin heavy chain VH3-21 gene. ROSS_AML_OF_FAB_M7_TYPE Top 100probe sets for pediatric acute myeloid 67 2.875 leukemia (AML) subtypeFAB M7 (also known as acute megakaryoblastic leukemia, AMKL).KEEN_RESPONSE_TO_ROSIGLITAZONE_UP Genes up-regulated in aorta biopsiesfrom mice 35 2.873 treated with rosiglitazone [PubChem = 77999].QI_HYPOXIA_TARGETS_OF_HIF1A_AND_FOXA2 Genes up-regulated by hypoxia inTRAMP-C 36 2.872 cells (prostatic cancer) expressing HIF1A and FOXA2[GeneID = 3091, 3170] off plasmid vectors.GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN Genes down-regulated incommon hematopoietic 62 2.851 progenitor cells isolated from bone marrowof patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID= 6223]. ELVIDGE_HYPOXIA_BY_DMOG_DN Genes down-regulated in MCF7 cells(breast 58 2.837 cancer) treated with hypoxia mimetic DMOG [PubChem =3080614]. GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_UP Genes up-regulatedin quiescent (G0) CD34+ 85 2.824 [GeneID = 8842] cells isolated fromperipheral blood of CML (chronic myeloid leukemia) patients compared tothe quiescent cells from normal donors. GALE_APL_WITH_FLT3_MUTATED_DNGenes down-regulated in acute promyelocytic 17 2.813 leukemia (APL)patients with mutated FLT3 [GeneID = 2322].TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_MONOCYTE_UP Genesup-regulated by RUNX1-RUNX1T1 20 2.78 [GeneID = 861; 862] fusion proteinin normal hematopoietic progenitors; their expression was sustained insubsequently developing monocytes. KANG_FLUOROURACIL_RESISTANCE_UP Genesup-regulated in gastric cancer cell lines 22 2.755 resistant to5-fluorouracil [PubChem = 3385]. CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_UPGenes up-regulated by 2-methoxyestradiol 46 2.755 (2ME2) [PubChem =1573] in the MM.1S cell line (multiple myeloma) sensitive todexamethasone [PubChem = 5743]. HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2Genes differentially expressed in hereditary breast 154 2.731 cancertumors with mutated BRCA1 [GeneID = 672] compared to those with mutatedBRCA2 [GeneID = 675]. MALONEY_RESPONSE_TO_17AAG_DN Down-regulated genesin A2780 cells (ovarian cancer) treated with 17AAG 69 2.725 [PubChem =6440175], a chemical with anticancer properties. IRITANI_MAD1_TARGETS_DNGenes down-regulated by overexpression of 40 2.719 MAD1 [GeneID = 4084]in primary thymocytes from RAG2 [GeneID = 5897] knockout mice.DELPUECH_FOXO3_TARGETS_DN Genes down-regulated in DL23 cells (colon 392.711 cancer) upon expression of an activated form of FOXO3 [GeneID =2309]. LUI_THYROID_CANCER_CLUSTER_3 Cluster 3: genes with similarexpression profiles 18 2.693 across follicular thyroid carcinoma (FTC)samples; genes in this cluster correlated well with the presence ofPAX8-PPARG [GeneID = 7849; 5468] fusion protein.DAVIES_MULTIPLE_MYELOMA_VS_MGUS_UP Genes up-regulated in multiplemyeloma (MM) 13 2.692 compared to monoclonal gammopathy of uncertainsignificance (MGUS). ELLWOOD_MYC_TARGETS_DN Genes down-regulated intransgenic mice 40 2.691 expressing human MYC [GeneID = 4609] inprostate. TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP Genesup-regulated in monocytes by RUNX1- 193 2.685 RUNX1T1 [GeneID = 861;862] fusion. WANG_TARGETS_OF_MLL_CBP_FUSION_DN Top 50 genesdown-regulated in granulocyte/macrophage 43 2.666 progenitors (GMP) uponexpression of MLL-CBP fusion [GeneID = 4297; 1387].RODWELL_AGING_KIDNEY_NO_BLOOD_DN Genes whose expression decreases withage in 146 2.664 normal kidney, excluding those with higher expressionin blood. MUELLER_COMMON_TARGETS_OF_AML_FUSIONS_UP Up-regulated targetgenes shared by acute 14 2.661 myeloid leukemia (AML) translocationproducts PML RARA [GeneID = 5371; 5914], AML1 ETO [GeneID = 861; 862],and PLZF RARA [GeneID = 5914; 7704]. SUZUKI_AMPLIFIED_IN_ORAL_CANCERHigh-level amplifications detected in oral 16 2.655 squamous cellcarcinoma (OSCC) lines by array- CGH analysis.MARCHINI_TRABECTEDIN_RESISTANCE_DN Genes down-regulated inchondrosarcoma and 48 2.628 ovarian carcinoma cell lines which developedresistance to trabectedin [PubChem = 3199]. NUTT_GBM_VS_AO_GLIOMA_UP Top50 marker genes for glioblastoma multiform 45 2.621 (GBM), a class ofhigh grade glioma. ALCALAY_AML_BY_NPM1_LOCALIZATION_UP Genesup-regulated in acute myeloid leukemia 133 2.619 (AML) with respect tocellular localization of NPM1 [GeneID = 4869]: cytoplasmic vs.nucleolar. AMIT_EGF_RESPONSE_480_HELA Genes whose expression peaked at480 min after 162 2.602 stimulation of HeLa cells with EGF [GeneID =1950]. MOOTHA_TCA Tricarboxylic acid related genes; based on 13 2.579literature and sequence annotation resources and converted to AffymetrixHG-U133A probe sets. PUJANA_BREAST_CANCER_LIT_INT_NETWORK Genesconstituting the LIT-Int network of proteins interacting with breastcancer 99 2.576 reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID= 672; 675; 472; 11200]; the interactions were manually curated from theliterature. ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM Proteinssecreted in co-culture of LKR-13 tumor 64 2.555 cells (non-small celllung cancer, NSCLC) and MEC stroma cells (endothelium).LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN Genes down-regulated in Wilm's tumorsamples 157 2.553 compared to fetal kidney. MUNSHI_MULTIPLE_MYELOMA_UPGenes up-regulated in multiple myeloma (MM) 79 2.551 compared to normalplasma cells from the patient's identical twin.CHEN_HOXA5_TARGETS_9HR_DN Genes down-regulated 9 h after induction of 402.541 HoxA5 [GeneID = 3205] expression in a breast cancer cell line.AZARE_STAT3_TARGETS Genes up-regulated in RPWE-1 cells by activated 232.537 STAT3 [GeneID = 6774]. DANG_MYC_TARGETS_UP Genes up-regulated byMYC [GeneID = 4609] and 125 2.534 whose promoters are bound by MYC,according to MYC Target Gene Database. MAYBURD_RESPONSE_TO_L663536_UPGenes up-regulated in H720 cells (lung cancer) 29 2.527 after treatmentwith L663536 (MK886) [PubChem = 105049], an inhibitor of leukotrienebiosynthesis. YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_10 Genesco-regulated in uterus during a time course 63 2.519 response toprogesterone [PubChem = 5994]: SOM cluster 10.SHAFFER_IRF4_TARGETS_IN_ACTIVATED_DENDRITIC_CELL IRF4 [GeneID = 3662]target genes up-regulated in 63 2.509 plasmacytoid dendritic cellscompared to monocytes. HUMMERICH_SKIN_CANCER_PROGRESSION_DN Selectedgenes down-regulated during progression 97 2.501 through benign tomalignant skin tumors formed by treatment with DMBA and TPA [PubChem =6001; 4792] chemicals in the two stage skin carcinogenesis model.ZHAN_MULTIPLE_MYELOMA_CD1_DN Top 50 down-regulated genes in cluster CD-1of 44 2.501 multiple myeloma samples with the characteristic expressionspike of CCND1 [GeneID = 595]. LIU_LIVER_CANCER Low abundancetranscripts specific to 37 2.485 hepatocellular carcinoma (HCC).ROVERSI_GLIOMA_COPY_NUMBER_UP Genes in the most frequently gained lociin a 94 2.479 panel of glioma cell lines. MOOTHA_GLUCONEOGENESIS Genesinvolved in gluconeogenesis; based on 30 2.474 literature and sequenceannotation resources and converted to Affymetrix HG-U133A probe sets.HONMA_DOCETAXEL_RESISTANCE Genes up-regulated in MCF7-ADR cell line 302.467 (breast cancer) resistant to docetaxel [PubChem = 148124].LIU_PROSTATE_CANCER_UP Genes up-regulated in prostate cancer samples. 912.463 COLLER_MYC_TARGETS_UP Genes up-regulated in 293T (transformedfetal 23 2.455 renal cell) upon expression of MYC [GeneID = 4609].BOYAULT_LIVER_CANCER_SUBCLASS_G123_UP Up-regulated genes inhepatocellular carcinoma (HCC) subclass G123, 42 2.453 defined byunsupervised clustering. DANG_REGULATED_BY_MYC_UP Genes up-regulated byMYC [GeneID = 4609], 66 2.45 according to the MYC Target Gene Database.AMIT_SERUM_RESPONSE_480_MCF10A Genes whose expression peaked at 480 minafter 34 2.442 stimulation of MCF10A cells with serum.NADLER_HYPERGLYCEMIA_AT_OBESITY Genes correlated with the development of56 2.395 hyperglycemia in obese mice.XU_RESPONSE_TO_TRETINOIN_AND_NSC682994_DN Genes down-regulatedsynergistically in NB4 14 2.363 cells (acute promyelocytic leukemia,APL) by tretinoin and NSC682994 [PubChem = 444795; 388304].TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP Genes up-regulatedin erythroid lineage cells by 153 −2.338 RUNX1-RUNX1T1 [GeneID = 861;862] fusion. BOYAULT_LIVER_CANCER_SUBCLASS_G2 Genes in hepatocellularcarcinoma (HCC) 27 −2.358 subclass G2, defined by unsupervisedclustering. TSAI_DNAJB4_TARGETS_UP Genes up-regulated in CL1-5 cells(lung cancer) 13 −2.389 overexpressing DNAJB4 [GeneID = 11080] off aplasmid vector. WILCOX_RESPONSE_TO_PROGESTERONE_UP Genes up-regulated inprimary cultures of ovarian 149 −2.394 surface epithlium cells exposedto progesterone [PubChem = 5994] for 5 days. LEE_AGING_CEREBELLUM_UPUpregulated in the cerebellum of aged adult mice 82 −2.409 (30-month) vsyoung adult (5-month) LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_UPGenes up-regulated between two breast carcinoma 82 −2.421 subtypes:metaplastic (MCB) and ductal (DCB). STEARMAN_TUMOR_FIELD_EFFECT_UPUp-regulated genes in the ‘Field Effect’ signature 35 −2.421 of normallung tissue adjacent to the tumor. MENSE_HYPOXIA_UP Hypoxia responsegenes up-regulated in both 97 −2.424 astrocytes and HeLa cell line.PENG_GLUTAMINE_DEPRIVATION_UP Genes up-regulated in BJAB cells(B-lymphoma) 36 −2.426 after glutamine [PubChem = 738] deprivation.WU_CELL_MIGRATION Genes associated with migration rate of 40 human 177−2.433 bladder cancer cells. KYNG_DNA_DAMAGE_BY_UV UV only respondinggenes in primary fibroblasts 60 −2.441 from young donors.KOBAYASHI_RESPONSE_TO_ROMIDEPSIN Genes up-regulated in MM-LH cells(malignant 19 −2.446 melanoma) after treatment with the HDAC inhibitorromidepsin (FK228) [PubChem = 5352062].MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN Down-regulated ‘cooperationresponse genes’: 64 −2.447 responded synergystically to the combinationof mutant TP53 and HRAS [GeneID = 7157; 3265] in YAMC cells (colon).OSAWA_TNF_TARGETS Genes up-regulated in Hc cells (normal 10 −2.454hepatocyte) by TNF [GeneID = 7124].TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_DN Genes down-regulated in CD34+[GeneID = 947] 29 −2.467 hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID = 4928; 3205] off a retroviral vector at 3 daysafter transduction. BROWNE_HCMV_INFECTION_12HR_UP Genes up-regulated inprimary fibroblast cell 107 −2.477 culture after infection with HCMV(AD169 strain) at 12 h time point that were not up-regulated at theprevious time point, 10 h. KENNY_CTNNB1_TARGETS_UP Genes up-regulated inHC11 cells (mammary 50 −2.489 epithelium) by expression of constantlyactive CTNNB1 [GeneID = 1499]. HUMMEL_BURKITTS_LYMPHOMA_DNDown-regulated genes constituting the molecular 15 −2.493 signature ofBurkitt's lymphoma.GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_YELLOW_UP Genes from theyellow module which are up-regulated in HAEC cells 31 −2.509 (primaryaortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).YE_METASTATIC_LIVER_CANCER Genes up-regulated in hepatocellularcarcinoma 25 −2.517 (HCC) with intra-hepatic metastasis compared to thenon-metastatic tumors. NAKAMURA_ADIPOGENESIS_EARLY_DN Genesdown-regulated in mesenchymal stem cells during early phase ofadipogenesis, 38 −2.518 defined as days 1 to 5 of culturing withadipogenic hormones. DORSAM_HOXA9_TARGETS_DN HOXA9 [GeneID = 3205]targets down-regulated 29 −2.536 in hematopoietic stem cells.PLASARI_TGFB1_TARGETS_1HR_UP Genes up-regulated in MEF cells (embryonic33 −2.546 fibroblast) upon stimulation with TGFB1 [GeneID = 7040] for 1h. CHIARETTI_T_ALL_RELAPSE_PROGNOSIS Genes whose expression predictedrelapse in less 19 −2.546 than 2 years after chemotherapy for adultpatients with T-ALL (T cell lymphoblastic leukemia).LINDSTEDT_DENDRITIC_CELL_MATURATION_D Genes down-regulated during thecourse of 66 −2.549 maturation of monocyte-derived dendritic cells (DC)in response to inflammatory stimuli (cluster D).VERHAAK_AML_WITH_NPM1_MUTATED_UP Genes up-regulated in acute myeloidleukemia 173 −2.552 (AML) patients with mutated NPM1 [GeneID = 4869].BROWNE_HCMV_INFECTION_20HR_DN Genes down-regulated in primary fibroblastcell 100 −2.568 culture after infection with HCMV (AD169 strain) at 20 htime point that were not down-regulated at the previous time point, 18h. PEREZ_TP53_AND_TP63_TARGETS Genes up-regulated in HMEC cells (primary196 −2.578 mammary epithelium) upon expression of both of TP53 [GeneID =7157] and the transcriptionally active isoform of TP63 [GeneID = 8626]off adenoviral vectors. HOFMANN_CELL_LYMPHOMA_DN Genes down-regulated inlymph nodes from 39 −2.578 patients with mantle cell lymphoma (MCL)compared to the non-malignant hyperplastic lymph nodes.CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP Genes up-regulated in APL(acute promyeolocytic 167 −2.582 leukemia) blasts expressing PML-RARAfusion [GeneID = 5371; 5914] compared to normal promyeloblasts.XU_CREBBP_TARGETS_DN Genes down-regulated in pro-B lymphocytes after 44−2.586 knockout of CREBBP [GeneID = 1387]. DAIRKEE_TERT_TARGETS_DN Genesdown-regulated in non-spontaneously 117 −2.589 immortalizing (NSI)primary breast cancer tumor cultures upon expression of TERT [GeneID =7015] off a retroviral vector. DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN Genesdown-regulated in multiple myeloma 26 −2.591 (MM) compared to monoclonalgammopathy of uncertain significance (MGUS).RASHI_RESPONSE_TO_IONIZING_RADIATION_6 Cluster 6: late responding genesactivated in ATM 83 −2.593 [GeneID = 472] deficient but not in the wildtype tissues. GALE_APL_WITH_FLT3_MUTATED_UP Genes up-regulated in acutepromyelocytic 55 −2.593 leukemia (APL) patients with mutated FLT3[GeneID = 2322]. WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN Genesdown-regulated in mucinous ovarian 64 −2.597 carcinoma tumors of grades1 and 2 compared to the normal ovarian survace epithelium tissue.KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN Genes down-regulated in AIDS-relatedprimary 56 −2.616 effusion lymphoma (PEL) samples compared to othertumor subtypes and normal B lymphocytes.HOFMANN_MYELODYSPLASTIC_SYNDROM_RISK_DN Genes down-regulated in bonemarrow hematopoietic stem cells 22 −2.617 (HSC, CD34+ [GeneID = 947])from patients with high risk of myelodysplastic syndrome (MDS) comparedto the low risk patients. TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UPGenes up-regulated in normal hematopoietic 182 −2.617 progenitors byRUNX1-RUNX1T1 [GeneID = 861; 862] fusion. NEWMAN_ERCC6_TARGETS_UP Genesup-regulated in Cockayne syndrome 24 −2.631 fibroblasts rescued byexpression of ERCC6 [GeneID = 2074] off a plasmid vector.KEEN_RESPONSE_TO_ROSIGLITAZONE_DN Genes down-regulated in aorta biopsiesfrom mice 101 −2.643 treated with rosiglitazone [PubChem = 77999].MCDOWELL_ACUTE_LUNG_INJURY_UP Genes up-regulated in the mouse model ofacute 44 −2.647 lung injury induced by inhaling nickel sulfate [PubChem= 24586]. PARK_TRETINOIN_RESPONSE_AND_RARA_PLZF_FUSION Genesup-regulated by tretinoin (ATRA) [PubChem = 444795] in 22 −2.65 U937cells (acute promyelocytic leukemia, APL) made resistant to the drug byexpression of the PLZF-RARA fusion [GeneID = 7704, 5914].WILLIAMS_ESR2_TARGETS_DN Genes uniquely down-regulated in T47D cells 10−2.655 (breast cancer) by induction of ESR2 [GeneID = 2100] expressionin the Tet-Off system. LIEN_BREAST_CARCINOMA_METAPLASTIC Genesup-regulated in metaplastic carcinoma of 33 −2.665 the breast (MCB)subclass 2 compared to the MCB subclass 1.NIKOLSKY_BREAST_CANCER_6P24_P22_AMPLICON Genes within amplicon 6p24-p22identified in a 20 −2.666 copy number alterations study of 191 breasttumor samples. SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 Cluster PAM2: genesup-regulated in 149 −2.671 hepatocellular carcinoma (HCC) vs normalliver tissue from mice deficient for TXNIP [GeneID = 10628].LINDSTEDT_DENDRITIC_CELL_MATURATION_A Maturation of monocyte-deriveddendritic cells 63 −2.675 (DC) in response to inflammatory stimuli:genes up-regulated only at 8 hr after the stimulation (cluster A).GOLDRATH_IMMUNE_MEMORY ‘Memory genes’ expressed uniquely in CD8+ 64−2.688 [GeneID = 925] memory T lymphocytes (compared with effector ornaive cells) CHIANG_LIVER_CANCER_SUBCLASS_POLYSOMY7_DN Marker genesdown-regulated in the ‘chromosome 23 −2.706 7 polysomy’ subclass ofhepatocellular carcinoma (HCC); characterized by polysomy of chromosome7 and by a lack of gains of chromosome 8q. GILDEA_METASTASIS Top genesdown-regulated in metastatic (T24T) vs 30 −2.724 non-metastatic (T24)bladder cancer cell lines. FARMER_BREAST_CANCER_CLUSTER_5 Cluster 5:selected 17q21_23 amplicon genes 19 −2.74 clustered together acrossbreast cancer samples. BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_DN Genes fromcluster 2: down-regulated in group C 31 −2.74 of tumors arising fromoverexpression of BCL2L1 and MYC [GeneID = 598; 4609] in plasma cells.GRABARCZYK_BCL11B_TARGETS_UP Genes up-regulated in Jurkat cells(transformed T 77 −2.756 lymphocytes) after knockdown of BCL11B [GeneID= 64919] byRNAi. HALMOS_CEBPA_TARGETS_UP Genes up-regulated in H358cells (lung cancer) by 48 −2.76 inducible expression of CEBPA [GeneID =1050] off plasmid vector. BROWNE_HCMV_INFECTION_6HR_DN Genesdown-regulated in primary fibroblast cell 157 −2.762 culture point afterinfection with HCMV (AD169 strain) at 6 h time point that were not down-regulated at the previous time point, 4 h.GUTIERREZ_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN Genes exclusivelydown-regulated in B 56 −2.787 lymphocytes from CLL (chronic lymphocyticleukemia) patients but with a similar expression pattern in the normalcells and in the cells from WM (Waldenstroem's macroblobulinemia)patients. GENTILE_UV_RESPONSE_CLUSTER_D2 Cluster d2: genesdown-regulated consistently in 41 −2.788 WS1 cells (fibroblast) between6 h and 24 h after irradiation with high dose UV-C.CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70 Differentially expressedgenes between high vs low ZAP70 [GeneID = 7535] 66 −2.788 acutelymphoblastic leukemia (ALL) cases with no known molecular aberrations.RAMALHO_STEMNESS_DN Genes depleted in embryonic, neural and 70 −2.796hematopoietic stem cells. HOOI_ST7_TARGETS_DN Genes down-regulated inPC-3 cells (prostate 117 −2.798 cancer) stably expressing ST7 [GeneID =7982] off a plasmid vector.GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP Genes from theblue module which are up- 132 −2.806 regulated in HAEC cells (primaryaortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3- glycerophosphorylcholine (oxPAPC).GROSS_HYPOXIA_VIA_ELK3_ONLY_UP Genes specifically up-regulated in SENDcells 32 −2.815 (skin endothelium) at hypoxia after knockdown of ELK3[GeneID = 2004] by RNAi. BOYAULT_LIVER_CANCER_SUBCLASS_G5_DNDown-regulated genes in hepatocellular 27 −2.816 carcinoma (HCC)subclass G5, defined by unsupervised clustering.PARK_TRETINOIN_RESPONSE_AND_PML_RARA_FUSION Genes up-regulated bytretinoin (ATRA) 30 −2.832 [PubChem = 444795] in U937 cells (acutepromyelocytic leukemia, APL) made sensitive to the drug by expression ofthe PML-RARA fusion [GeneID = 5371; 5914]. TIAN_TNF_SIGNALING_VIA_NFKBGenes modulated in HeLa cells (cervical 28 −2.834 carcinoma) by TNF[GeneID = 7124] via NFKB pathway. GROSS_HYPOXIA_VIA_ELK3_DN Genesdown-regulated in SEND cells (skin 153 −2.87 endothelium) at hypoxiawith ELK3 [GeneID = 2004] knockdown by RNAi.OKUMURA_INFLAMMATORY_RESPONSE_LPS Genes up-regulated in mast cells (MC)after 177 −2.885 stimulation with a bacterial lipopolysaccharide (LPS).HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN Genes down-regulated in T helper cells(defines as CD4+) isolated from patients 114 −2.885 with mucosisfungoides compared to those from normal control donors.SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP Genes up-regulated in theurogenital sinus (UGS) 168 −2.891 of day E16 females exposed to theandrogen dihydrotestosterone [PubChem = 10635] for 6 h.ZHAN_MULTIPLE_MYELOMA_PR_DN Top 50 down-regulated genes in cluster PR of44 −2.897 multiple myeloma samples characterized by increased expressionof proliferation and cell cycle genes. LU_TUMOR_VASCULATURE_UP Genesup-regulated in endothelial cells derived 29 −2.899 from invasiveovarian cancer tissue. LEE_DOUBLE_POLAR_THYMOCYTE Genes enriched in thedouble polar (DP) 26 −2.906 thymocyte compared to all other T lymphocytedifferentiation stages. MAHADEVAN_RESPONSE_TO_MP470_UP Top genesup-regulated in the GIST 19 −2.906 (gastrointestinal stromal tumor) cellline resistant to imatinib [PubChem = 5291] after treatment with MP470,a protein kinase inhibitor. MORI_IMMATURE_B_LYMPHOCYTE_UP Up-regulatedgenes in the B lymphocyte 52 −2.907 developmental signature based onexpression profiling of lymphomas from the Emu-myc transgenic mice: theimmature B stage. SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP Selectedgenes up-regulated in peripheral blood 82 −2.907 monocytes (PBMC) ofpatients with hepatocellular carcinoma (HCC) compared to those withchronic hepatitis. ROETH_TERT_TARGETS_UP Genes up-regulated in Tlymphocytes 14 −2.909 overexpressing TERT [GeneID = 7015] off aretrovirus vector. STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP Genesup-regulated in prefrontal cortex (PFC) of 190 −2.911 mice carrying ahemizygotic microdeletion in the 22q11.2 region.CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_UP Marker genes up-regulated inthe ‘unannotated’ 83 −2.918 subclass of hepatocellular carcinoma (HCC)samples. YOSHIOKA_LIVER_CANCER_EARLY_RECURRENCE_UP Genes up-regulated inhepatocellular carcinoma 38 −2.919 (HCC) samples from patients withearly recurrence (within 2 years after surgery) after resection.VANASSE_BCL2_TARGETS_DN Genes down-regulated in primary B lymphocytes 72−2.924 engineered to overexpress BCL2 [GeneID = 12043].BROCKE_APOPTOSIS_REVERSED_BY_IL6 Genes changed in INA-6 cells (multiplemyeloma, 141 −2.925 MM) by re-addition of IL6 [GeneID = 3569] after itsinitial withdrawal for 12 h. NIKOLSKY_BREAST_CANCER_8P12_P11_AMPLICONGenes within amplicon 8p12-p11 identified in a 52 −2.928 copy numberalterations study of 191 breast tumor samples.JOHNSTONE_PARVB_TARGETS_1_DN Genes down-regulated in MDA-MB-231 cells 61−2.937 (breast cancer) upon overexpression of PARVB [GeneID = 29780]under all three culture conditions.CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN Selected genesdown-regulated during invasion of 36 −2.937 lymphatic vessels duringmetastasis. WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_UP Selected geneswith immunologic function which 30 −2.95 were reciprocally changed inevasion and tolerogenic tumor models.TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_UP Genesup-regulated in ductal carcinoma vs normal 72 −2.956 lobular breastcells. ZHANG_RESPONSE_TO_CANTHARIDIN_UP Genes up-regulated in HL-60cells (promyeloid 19 −2.961 leukemia) by cantharidin [PubChem =6708701]. KANG_GIST_WITH_PDGFRA_UP Genes up-regulated ingastrointestinal stromal 48 −2.965 tumors (GIST) with PDGFRA [GeneID =5156] mutations. MARSHALL_VIRAL_INFECTION_RESPONSE_DN Genesdown-regulated in the influenza-specific 29 −2.977 CD8+ [GeneID = 925] Tlymphocytes from bronchoalveolar lavage (BAL) compared to those fromspleen. EHRLICH_ICF_SYNDROM_UP Up-regulated in B lymphocytes frompatients with 13 −2.981 ICF syndrome caused by mutations in DNMT3B[GeneID = 1789] compared to normals.CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP Genes up-regulated inreverted NIH3T3 cells 117 −2.983 (fibroblasts transformed by activatedKRAS [GeneID = 3845] which then reverted to normal cells upon stableover-expression of a dominant negative form of CDC25 [GeneID = 5923]) vsnormal fibroblasts. WANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP Up-regulatedgenes in myeloid progenitors 27 −2.993 immortalized by HOXA9 [GeneID =3205] vs those immortalized by HOXA9 and MEIS1 [GeneID = 4211].GHANDHI_BYSTANDER_IRRADIATION_UP Genes significantly (FDR &lt; 10%)up-regulated 81 −2.993 in IMR-90 cells (fibroblast) in response tobystander irradiation. HUANG_DASATINIB_RESISTANCE_UP Genes whoseexpression positively correlated 78 −2.998 with sensitivity of breastcancer cell lines to dasatinib [PubChem = 3062316].SHIN_B_CELL_LYMPHOMA_CLUSTER_8 Cluster 8 of genes distinguishing amongdifferent 35 −3.001 B lymphocyte neoplasms. ALONSO_METASTASIS_DNDown-regulated genes in melanoma tumors that 25 −3.023 developedmetastatic disease compared to primary melanoma that did not.PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN Genes down-regulated after 1 hof TGFB1 105 −3.029 [GeneID = 7040] stimulation in MEF cells (embryonicfibroblast) with NFIC [GeneID = 4782] knockout vs wild type MEFs.GAVIN_FOXP3_TARGETS_CLUSTER_T4 Cluster T4 of genes with similarexpression 91 −3.046 profiles in thymic T lymphocytes after FOXP3[GeneID = 50943] loss of function (LOF).GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB Genes identified as syntheticlethal with imatinib 135 −3.054 [PubChemID = 5291] in RNAi screen inK562 cells (CML, chronic myelogenous leukemia).BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP Up-regulated genes inMDA-MB-435 cells (breast 114 −3.062 cancer) undergoing G2/M arrest aftertreatment with 2-methoxyestradiol (2ME2)[PubChem = 1573].SASSON_RESPONSE_TO_GONADOTROPHINS_DN Genes down-regulated in primarygranulosa cells 84 −3.065 after stimulation with LH or FSH gonadotrophichormones for 24 h. LIU_TARGETS_OF_VMYB_VS_CMYB_DN Gene regulated in theopposite directions by v- 42 −3.08 MYB (DN) and c-MYB (UP) variants ofCMYB [GeneID = 4602] overexpressed in primary monocyte cultures offadenoviral vectors. SANA_TNF_SIGNALING_UP Genes up-regulated in fiveprimary endothelial 83 −3.091 cell types (lung, aortic, iliac, dermal,and colon) by TNF [GeneID = 7124]. SHIN_B_CELL_LYMPHOMA_CLUSTER_3Cluster 3 of genes distinguishing among different 27 −3.093 B lymphocyteneoplasms. LU_TUMOR_ENDOTHELIAL_MARKERS_UP Genes specificallyup-regulated in tumor 22 −3.118 endothelium. XU_AKT1_TARGETS_6HR Genesup-regulated in DU-145 cells (prostate 27 −3.12 cancer) expressing adominant negative form of AKT1 [GeneID = 207] upon sham-treatment for 6h (as a control for the HGF [GeneID = 3082] experiments).CROONQUIST_NRAS_SIGNALING_UP Genes up-regulated in ANBL-6 cell line(multiple 39 −3.127 myeloma, MM) expressing a constantly active form ofNRAS [GeneID = 4893] off a plasmid vector compared to those grown in thepresence of IL6 [GeneID = 3569]. DAUER_STAT3_TARGETS_UP Top 50 genesup-regulated in A549 cells (lung 47 −3.127 cancer) expressing STAT3[GeneID = 6774] off an adenovirus vector. AKL_HTLV1_INFECTION_DN Genesdown-regulated in WE17/10 cells (CD4+ 66 −3.168 [GeneID = 920] Tlymphocytes) infected by HTLV1 (and thus displaying low CD7 [GeneID =924]) compared to the uninfected (i.e., CD7+) cells.MARSON_FOXP3_CORE_DIREC_TARGETS Direct FOXP3 [GeneID = 50943] targetsthat 18 −3.18 exhibit consistent transcriptional behavior in hybridomaand in ex vivo T lymphocytes. FLOTHO_PEDIATRIC_ALL_THERAPY_RESPONSE_DNDown-regulated genes significantly associated 29 −3.19 with positiveminimal residual disease (MRD) on day 46 after chemotherapy treatment ofchildren with acute lymphoblastic leukemia (ALL).WONG_ENDMETRIUM_CANCER_DN Genes down-regulated in cancer endometrium 80−3.194 samples compared to the normal endometrium.SCHEIDEREIT_IKK_INTERACTING_PROTEINS Genes encoding IkappaB kinase (IKK)interacting 58 −3.208 proteins. BORCZUK_MALIGNANT_MESOTHELIOMA_DN Genesdown-regulated in biphasic (mixed) vs 100 −3.212 epithelial subtypes ofmalignant peritoneal mesothelioma. RUIZ_TNC_TARGETS_UP Genesup-regulated in T98G cells (glioblastoma) 149 −3.218 by TNC [GeneID =3371]. PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_3 Genes regulated in MCF7cells (breast cancer) by 19 −3.238 expression of the truncated (611-CTF)form of ERBB2 [GeneID = 2064] at both 15 h and 60 h time points.GOUYER_TATI_TARGETS_UP Genes up-regulated in constitutively invasive HT-10 −3.324 29 5M21 cells (colon cancer) vs those expressing functionallyinactive TATI [GeneID = 6690]. ZHAN_MULTIPLE_MYELOMA_DN Genes mostsignificantly down-regulated in 39 −3.337 multiple myeloma samples,compared to normal bone marrow plasma cells.PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN Genes down-regulated in OV-90cells (ovarian 143 −3.342 cancer) exposed to ascites which inhibitedinvasion. TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_GRANULOCYTE_DN Genesdown-regulated in granulocytes by 16 −3.343 RUNX1-RUNX1T1 [GeneID = 861;862] fusion. MARSON_FOXP3_TARGETS_UP Genes up-regulated by FOXP3 [GeneID= 50943] 65 −3.343 in both ex vivo and hybridoma cells.TING_SILENCED_BY_DICER Epigenetically silenced genes up-regulated in 30−3.355 HCT116 cells (colon cancer) hypomorphic for DICER1 [GeneID =23405]. HINATA_NFKB_TARGETS_KERATINOCYTE_UP Genes up-regulated inprimary keratinocytes by 90 −3.364 expression of p50 (NFKB1) and p65(RELA) [GeneID = 4790; 5970] components of NFKB.WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_DN Selected genes withimmunologic function which 13 −3.404 were reciprocally changed inevasion and tolerogenic tumor models. MARSON_FOXP3_TARGETS_STIMULATED_UPGenes with promoters bound by FOXP3 29 −3.414 [GeneID = 50943],dependent on it, and up- regulated in hybridoma cells stimulated by PMA[PubChem = 4792] and ionomycin [PubChem = 3733].BUCKANOVICH_T_LYMPHOCYTE_HOMING_ON_TUMOR_UP Genes up-regulated inmicrodissected endothelial 23 −3.433 samples from ovarian cancer tumorswith tumor- infiltrating lymphocytes (TIL) vs those without TILs.LU_TUMOR_ANGIOGENESIS_UP Up-regulated genes of putative pathways 25−3.444 stimulated in tumor endothelial cells by papillary serous ovarianepithelial tumor cells. BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN Genesdown-regulated in NIH3T3 cells 48 −3.445 (fibroblasts) after treatmentwith Y27632 [PubChem = 123862], an inhibitor of ROCK proteins; thechanges did not depend on expression of constitutively active (Q63L)form of RHOA [GeneID = 387]. HOOI_ST7_TARGETS_UP Genes up-regulated inPC-3 cells (prostate cancer) 91 −3.447 stably expressing ST7 [GeneID =7982] off a plasmid vector. DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBERThe lung adenocarcinoma TSP (tumor sequencing 100 −3.46 project) genesshowing strong correlation between DNA copy number variation and geneexpression. CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP Top 200 markergenes up-regulated in the 175 −3.481 ‘proliferation’ subclass ofhepatocellular carcinoma (HCC); characterized by increasedproliferation, high levels of serum AFP [GeneID = 174], and chromosomalinstability. BASSO_CD40_SIGNALING_UP Gene up-regulated by CD40 [GeneID =958] 97 −3.489 signaling in Ramos cells (EBV negative Burkitt lymphoma).JISON_SICKLE_CELL_DISEASE_UP Genes up-regulated in peripheral blood 176−3.5 mononuclear cells (PBMC) from sickle cell disease patients comparedto those from healthy subjects.PEDERSEN_TARGETS_OF_611CTF_ISOFORM_OF_ERBB2 Genes up-regulated in MCF7cells (breast cancer) 73 −3.533 more than three-fold by the truncatedform 611- CTF of ERBB2 [GeneID = 2064] and less than two-fold by thefull-length ERBB2 [GeneID = 2064]. WAMUNYOKOLI_OVARIAN_CANCER_LMP_DNGenes down-regulated in mucinous ovarian 192 −3.534 carcinoma tumors oflow malignant potential (LMP) compared to normal ovarian surfaceepithelium tissue. TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DNGenes down-regulated in monocytes by RUNX1- 53 −3.537 RUNX1T1 [GeneID =861; 862] fusion. MARSON_FOXP3_TARGETS_DN Genes down-regulated by FOXP351 −3.54 [GeneID = 50943] in both ex vivo and hybridoma cells.NIKOLSKY_BREAST_CANCER_19Q13.1_AMPLICON Genes within amplicon 19q13.1identified in a 21 −3.543 copy number alterations study of 191 breasttumor samples. HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN Genes down-regulatedin hematopoietic precursor 73 −3.554 cells conditionally expressingHOXA9 and MEIS1 [GeneID = 3205; 4211].GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN Genes down-regulated inmetastatic breast cancer 171 −3.565 tumors having type 2 amplificationin the 20q13 region; involves MYBL2, STK6 and ZNF217 [GeneID = 4605;6790; 7764] LENAOUR_DENDRITIC_CELL_MATURATION_DN Genes down-regulatedduring in vitro maturation 125 −3.586 of CD14+ [GeneID = 929] monocytes(day 0) into immature (day 7) and mature dendritic cells (day 14).LIU_SOX4_TARGETS_UP Genes up-regulated in LNCaP cells (prostate 134−3.611 cancer) by overexpression of SOX4 [GeneID = 6659] anddown-regulated by its RNAi knockdown. VERHAAK_GLIOBLASTOMA_NEURAL Genescorrelated with neural type of glioblastoma 125 −3.632 multiformetumors. ONO_AML1_TARGETS_UP Genes up-regulated in CD4+ [GeneID = 920] T24 −3.633 lymphocytes by expression of AML1 [GeneID = 861] off a viralvector. FERRANDO_TAL1_NEIGHBORS Nearest neighbors of TAL1 [GeneID =6886], 21 −3.645 based on the close agreement of their expressionprofiles with that of TAL1 in pediatric T cell acute lymphoblasticleukemia (T-ALL) ZHENG_IL22_SIGNALING_UP Genes up-regulated in ex-vivocolonic tissue after 53 −3.65 treatment with IL22 [GeneID = 50616].XU_RESPONSE_TO_TRETINOIN_AND_NSC682994_UP Genes up-regulatedsynergistically in NB4 cells 17 −3.67 (acute promyelocytic leukemia,APL) by tretinoin and NSC682994 [PubChem = 444795; 388304].BROWNE_HCMV_INFECTION_4HR_UP Genes up-regulated in primary fibroblastcell 54 −3.67 culture point after infection with HCMV (AD169 strain) at4 h time point that were not up-regulated at the previous time point, 2h. ZHAN_EARLY_DIFFERENTIATION_GENES_DN B lymphocyte earlydifferentiation genes (EDG): 42 −3.679 top genes down-regulated intonsil B lymphocytes (TBC) compared to the tonsil plasma cells (TPC).GRANDVAUX_IRF3_TARGETS_UP Genes up-regulated in Jurkat cells (Tlymphocyte) 15 −3.682 by expression of a constitutively active form ofIRF3 [GeneID = 3661]. HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN Genesdown-regulated in hematopoietic 61 −3.692 progenitor cells (HPC) of Tlymphocyte and NK (natural killer) lineage. BOYLAN_MULTIPLE_MYELOMA_D_DNGenes down-regulated in group D of tumors 76 −3.723 arising fromoverexpression of BCL2L1 and MYC [GeneID = 598; 4609] in plasma cells.ONO_AML1_TARGETS_DN Genes down-regulated in CD4+ [GeneID = 920] T 39−3.73 lymphocytes by expression of AML1 [GeneID = 861] off a viralvector. MARZEC_IL2_SIGNALING_DN Genes down-regulated by IL2 [GeneID =3558] in 34 −3.746 cells derived from CD4+ [GeneID = 920] cutaneousT-cell lymphoma (CTCL). BILBAN_B_CLL_LPL_DN Genes down-regulated inB-CLL (B-cell chronic 39 −3.749 leukemia) samples expressing high levelsof LPL [GeneID = 4023] compared with those expressing low levels of thegene. RODRIGUES_THYROID_CARCINOMA_DN Genes down-regulated in poorlydifferentiated 76 −3.757 thyroid carcinoma (PDTC) compared to anaplasticthyroid carcinoma (ATC). MARTINELLI_IMMATURE_NEUTROPHIL_DNNeutrophil-specific genes down-regulated in 11 −3.76 comparison ofimmature with mature neutrophils. MORI_PLASMA_CELL_DN Down-regulatedgenes in the B lymphocyte 33 −3.763 developmental signature, based onexpression profiling of lymphomas from the Emu-myc transgenic mice:plasma cell. HOEBEKE_LYMPHOID_STEM_CELL_UP Genes up-regulated in thecommon lymphoid 91 −3.767 progenitor (CLP, defined as CD34+CD38−CD7+[GeneID = 947; 952; 924]) compared to a multipotent cord blood cell(defined as CD34+CD38+CD7−). STAMBOLSKY_TARGETS_OF_MUTATED_TP53_DN Genesrepressed in SKBR3 cells (breast cancer) 49 −3.768 by mutated TP53[GeneID = 7157]. DER_IFN_GAMMA_RESPONSE_UP Genes up-regulated in HT1080(fibrosarcoma) 69 −3.782 cells by treatment with interferon gamma for 6h. TAVOR_CEBPA_TARGETS_UP Genes up-regulated in KCL22 cells (chronic 47−3.824 myelogenous leukemia, CML, with BCR-ABL1 [GeneID = 613; 25]fusion) by expression of CEBPA [GeneID = 1050].FOSTER_TOLERANT_MACROPHAGE_UP Class T (tolerizeable) genes: inducedduring the 149 −3.841 first LPS stimulation and either not re-induced orinduced to a much lesser degree in tolerant macrophages.NEMETH_INFLAMMATORY_RESPONSE_LPS_UP Genes up-regulated in RAW 264.7cells 83 −3.858 (macrophage) 3 hr after stimulation with bacteriallipopolysaccharide (LPS). SEKI_INFLAMMATORY_RESPONSE_LPS_UP Genesup-regulated in hepatic stellar cells after 75 −3.877 stimulation withbacterial lipopolysacharide (LPS).ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE Genes in the‘mesenchymal transition signature’ 64 −3.881 common to all invasivecancer types. GEISS_RESPONSE_TO_DSRNA_UP Genes up-pregulated by dsRNA inGRE cells 37 −3.905 (glioma; no interferon system).DUTTA_APOPTOSIS_VIA_NFKB NF-kB target genes involved in the regulationof 33 −3.925 programmed cell death. DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DNGenes exclusively down-regulated in fibroblasts 84 −3.945 expressing theTTD mutant form of ERCC3 [GeneID = 2071], after UVC irradiation.GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_UP Genes up-regulated in commonhematopoietic 39 −3.999 progenitor cells isolated from bone marrow ofpatients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID =6223]. GENTLES_LEUKEMIC_STEM_CELL_UP Genes up-regulated in LSC (leukemicstem) cells 29 −4.016 compared to LPC (leukemia progenitor) cells fromAML (acute myeloid leukemia) tumor samples. VALK_AML_CLUSTER_5 Top 40genes from cluster 5 of acute myeloid 32 −4.024 leukemia (AML)expression profile; 96% of the samples are FAB M4 or M5 subtype.GAVIN_PDE3B_TARGETS Genes changed in peripheral regulatory T 21 −4.046lymphocytes that depend on PDE3B [GeneID = 5140]. SU_THYMUS Genesup-regulated specifically in human thymus. 20 −4.093BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS Genes significantly up-regulated inthe blood 28 −4.116 mononuclear cells from patients with systemic lupuserythematosus compared to those from healthy persons.TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP Genes up-regulated in CD34+[GeneID = 947] 188 −4.128 hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID = 4928; 3205] off a retroviral vector at 10 daysafter transduction. WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_UPGenes up-regulated in gastric mucosal tissue of 56 −4.145 mice on 2%cholesterol [PubChem = 5997] diet and infected with H. pylori vs thoseinfected with H. pylori while on 0% cholesterol diet.IKEDA_MIR30_TARGETS_UP Genes up-regulated in hypertrophic hearts (due to115 −4.171 expression of constitutively active form of PPP3CA [GeneID =5530]) and predicted to be targets of miR-30 microRNA.CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN Top 200 marker genesdown-regulated in the 168 −4.178 ‘CTNNB1’ subclass of hepatocellularcarcinoma (HCC); characterized by activated CTNNB1 [GeneID = 1499].TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP Genes up-regulated in CD34+[GeneID = 947] 167 −4.179 hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID = 4928; 3205] off a retroviral vector at 16 daysafter transduction. NAKAJIMA_EOSINOPHIL Top 30 increased eosinophilspecific transcripts. 29 −4.191 WANG_CLIM2_TARGETS_DN Genesdown-regulated in MCF7 cells (breast 177 −4.192 cancer) engineered toconditionally express a dominant negative form of CLIM2 [GeneID = 8861]by a Tet Off system. MORI_LARGE_PRE_BII_LYMPHOCYTE_DN Down-regulatedgenes in the B lymphocyte 58 −4.196 developmental signature, based onexpression profiling of lymphomas from the Emu-myc transgenic mice: theLarge Pre-BII stage. GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN Genesdown-regulated in quiescent CD34+ 93 −4.204 [GeneID = 8842] cellsisolated from peripheral blood of normal donors compared to the dividingcells from CML (chronic myeloid leukemia) patients.GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP Genes up-regulated inquiescent vs dividing 65 −4.215 CD34+ [GeneID = 8842] cells isolatedfrom peripheral blood of normal donors. KIM_GLIS2_TARGETS_UP Partiallist of genes up-regulated in the kidney of 82 −4.247 GLIS2 [GeneID =84662] knockout mice compared to the wild type.LINDSTEDT_DENDRITIC_CELL_MATURATION_C Maturation of monocyte-deriveddendritic cells 68 −4.252 (DC) in response to inflammatory stimuli:genes up-regulated only at 48 hr after the stimulation (cluster C).GAURNIER_PSMD4_TARGETS Inflammatory cytokines, chemokines and their 67−4.255 cognate receptors up-regulated in THP-1 cells (monocyte) aftertreatment with PSMD4 [GeneID = 5710]. RADAEVA_RESPONSE_TO_IFNA1_UP Genesup-regulated in primary hepatocytes and 51 −4.259 Hep3B (hepatocyte)cells in response to IFNA [GeneID = 3439].GAVIN_FOXP3_TARGETS_CLUSTER_P3 Cluster P3 of genes with similarexpression 154 −4.291 profiles in peripheral T lymphocytes after FOXP3[GeneID = 50943] loss of function (LOF). DAZARD_UV_RESPONSE_CLUSTER_G6Cluster G6: genes increasingly down-regulated in 151 −4.326 NHEK cells(normal keratinocyte) after UV-B irradiation.CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP Genes up-regulated in secondaryAPL (acute 39 −4.348 promyelocytic leukemia) compared to the de novotumors. BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_DN Genes down-regulated inB lymphocytes from 39 −4.362 patients with primary immunodefiencysyndrome. TIEN_INTESTINE_PROBIOTICS_2HR_DN Genes down-regulated inCaco-2 cells (intestinal 86 −4.38 epithelium) after coculture with theprobiotic bacteria L. casei for 2 h. SWEET_KRAS_TARGETS_UP Genesupregulated in KRAS [GeneID = 3845] 81 −4.407 knockdown vs control in ahuman cell line. WORSCHECH_TUMOR_REJECTION_UP Up-regulated genesdefining rejection of 55 −4.409 mammary carcinoma (MMC) tumors.LEE_NAIVE_T_LYMPHOCYTE Genes enriched in the naive circulating T 18−4.445 lymphocytes compared to the earlier differentiation stages.DUNNE_TARGETS_OF_AML1_MTG8_FUSION_UP Genes up-regulated in Kasumi-1cells (acute 48 −4.447 myeloid leukaemia (AML) with the t(8; 21)translocation) after knockdown of the AML1 MTG8 fusion [GeneID = 861;862] by RNAi. RAGHAVACHARI_PLATELET_SPECIFIC_GENES Genes in this setcorrespond to the most abuntant 68 −4.459 transcripts that are alsospecific to platelets. RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP Genesup-regulated in ALL (acute lymphoblastic 75 −4.463 leukemia) blastsafter 1 week of treatment with glucocorticoids.BILD_CTNNB1_ONCOGENIC_SIGNATURE Genes selected in supervised analyses to80 −4.496 discriminate cells expressing activated beta- catenin (CTNNB1)[GeneID = 1499] oncogene from control cells expressing GFP.KAMIKUBO_MYELOID_CEBPA_NETWORK Network of differentially expressedmyeloid genes 28 −4.511 centered around CEBPA [GeneID = 1050].FINETTI_BREAST_CANCER_KINOME_GREEN Genes in the green cluster of proteinkinases 16 −4.52 distinguishing between luminal A and basal breastcancer subtypes. EINAV_INTERFERON_SIGNATURE_IN_CANCER A gene expressionsignature found in a subset of 27 −4.532 cancer patients suggestive of aderegulated immune or inflammatory response.SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP Genes up-regulated inCT60/4 cells (breast cancer 68 −4.55 reverted to normal by transfer ofchromosome 8p region) vs parental MDA-MB-231 cells (deleted chromosome8p). TIEN_INTESTINE_PROBIOTICS_6HR_DN Genes down-regulated in Caco-2cells (intestinal 161 −4.565 epithelium) after coculture with theprobiotic bacteria L. casei for 6 h. SENGUPTA_EBNA1_ANTICORRELATED Geneswhose reduced expression in 161 −4.565 nasopharyngeal carinoma (NPC)correlated most with the increased expression of EBNA1 [GeneID =3783774], a latent gene of Epstein-Barr virus (EBV). ZHU_CMV_8_HR_UPUp-regulated at 8 h following infection of primary 46 −4.566 humanforeskin fibroblasts with CMVKUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS_AND_CYCLIC_RGD Inflammatorycytokines and their receptors 21 −4.577 moduated in brain tumors inresponse to treatment with cyclic RGD peptide prior to the oncocyticvirus therapy. MORI_PRE_BI_LYMPHOCYTE_DN Down-regulated genes in the Blymphocyte 76 −4.592 developmental signature, based on expressionprofiling of lymphomas from the Emu-myc transgenic mice: the Pre-BIstage. WIELAND_UP_BY_HBV_INFECTION Genes induced in the liver duringhepatitis B 96 −4.641 (HBV) viral clearance in chimpanzees.LIU_VAV3_PROSTATE_CARCINOGENESIS_UP Selected genes up-regulated inprostate tumors 88 −4.649 developed by transgenic mice overexpressingVAV3 [GeneID = 10451] in prostate epithelium.TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN Genes down-regulated innormal hematopoietic 181 −4.692 progenitors by RUNX1-RUNX1T1 [GeneID =861; 862] fusion. ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP Genesdown-regulated in P493-6 cells (B 82 −4.732 lymphocyte, Burkitt'slymphoma model) by MYC [GeneID = 4609] and up-regulated by RNAiknockdown of TFRC [GeneID = 7037]. KRASNOSELSKAYA_ILF3_TARGETS_UPUp-regulated in GHOST(3)CXCR4 cells 38 −4.82 (osteosarcoma) upon ectopicexpression of ILF3 [GeneID = 3609]. GAVIN_FOXP3_TARGETS_CLUSTER_P4Cluster P4 of genes with similar expression 99 −4.832 profiles inperipheral T lymphocytes after FOXP3 [GeneID = 50943] loss of function(LOF). DAZARD_RESPONSE_TO_UV_SCC_DN Genes down-regulated in SCC12B2cells 121 −4.833 (squamous cell carcinoma) by UV-B irradiation.LINDSTEDT_DENDRITIC_CELL_MATURATION_B Maturation of monocyte-deriveddendritic cells 50 −4.835 (DC) in response to inflammatory stimuli:genes up-regulated both at 8 hr and 48 hr after the stimulation (clusterB). MORI_MATURE_B_LYMPHOCYTE_UP Up-regulated genes in the B lymphocyte88 −4.87 developmental signature, based on expression profiling oflymphomas from the Emu-myc transgenic mice: the mature BNAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP Top 100 probe sets contributing tothe positive 70 −4.902 side of the 1st principal component;predominantly associated with spindle cell and pleomorphic sarcomasamples. ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP Hepatic graft versushost disease (GVHD), day 127 −4.903 35: genes up-regulated in allogeneicvs syngeneic bone marrow transplant.BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP Genes up-regulated inmedullary breast cancer 197 −4.942 (MBC) relative to ductal breastcancer (DBD). TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DNGenes down-regulated in lobular carcinoma vs 73 −4.994 normal lobularbreast cells. DER_IFN_BETA_RESPONSE_UP Genes up-regulated in HT1080(fibrosarcoma) 100 −5.009 cells by treatment with interferon beta for 6h. CHAN_INTERFERON_PRODUCING_DENDRITIC_CELL Genes up-regulated in spleeninterferon-producing 10 −5.027 dendritic cells (IKDC) compared toplasmacytoid dendritic cells (PDC) and conventional dendritic cells(cDC). KIM_GERMINAL_CENTER_T_HELPER_UP Genes up-regulated in germinalcenter T helper 65 −5.041 cells compared to other CD4+ [GeneID = 920] Tlymphocyte types. HAHTOLA_SEZARY_SYNDROM_UP Genes up-regulated inmonocytes isolated from 96 −5.05 peripheral blood samples of Sezarysyndrome patients compared to those from healthy normal donors.BOYLAN_MULTIPLE_MYELOMA_PCA1_UP Top up-regulated genes from principalcomponent 98 −5.089 1 (PCA1) which captures variation between normalplasma cells and tumors arising from aberrant expression of BCL2L1 andMYC [GeneID = 598; 4609]. GAVIN_FOXP3_TARGETS_CLUSTER_P7 Cluster P7 ofgenes with similar expression 89 −5.099 profiles in peripheral Tlymphocytes after FOXP3 [GeneID = 50943] loss of function (LOF).ZHANG_INTERFERON_RESPONSE Interferon-inducible genes up-regulated inA549 22 −5.1 cells (lung cancer) infected with a respiratory syncytialvirus (RSV) that had its NS1 [GeneID = 1494468] gene knocked down byRNAi. LU_IL4_SIGNALING Genes up-regulated in peripheral B lymphocytes 91−5.159 after incubation with IL4 [GeneID = 3565] for 4 h.HAHTOLA_CTCL_PATHOGENESIS Differentially expressed genes relevant to 16−5.221 pathogenesis of cutaneous T cell lymphoma (CTCL).DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN Genes down-regulated in CD34+[GeneID = 947] 106 −5.234 cells isolated from bone marrow of CML(chronic myelogenous leukemia) patients, compared to those from normaldonors. ONO_FOXP3_TARGETS_DN Genes down-regulated in CD4+ [GeneID = 920]T 41 −5.235 lymphocytes transduced with FOXP3 [GeneID = 50943].TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP Genesup-regulated in lobular carcinoma vs 68 −5.314 normal ductal breastcells. ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN Genes with promoters boundby FOXP3 36 −5.329 [GeneID = 50943] and which are down-regulated only inmature (peripheral blood) regulatory CD4+ [GeneID = 920] T lymphocytes.IKEDA_MIR133_TARGETS_UP Genes up-regulated in hypertrophic hearts (dueto 43 −5.33 expression of constitutively active form of PPP3CA [GeneID =5530]) and predicted to be targets of miR-133 microRNA.HUANG_GATA2_TARGETS_UP Genes up-regulated in G1ME cells 141 −5.337(megakaryocyte/erythroid progenitor lacking GATA1 [GeneID = 2623]) uponknockdown of GATA2 [GeneID = 2624] by RNAi.VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP Up-regulated genesdistinguishing between two 172 −5.379 subtypes of gastric cancer:advanced (AGC) and early (EGC). BOWIE_RESPONSE_TO_TAMOXIFEN Genesup-regulated by tamoxifen 18 −5.393 [PubChem = 5376] in HMEC-E6 cells(mammary epithelial cells damaged by expression of HPV-16 E6 [GeneID =1489078]). TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP Genes up-regulatedin CD34+ [GeneID = 947] 178 −5.46 hematopoetic cells by expression ofNUP98- HOXA9 fusion [GeneID = 4928; 3205] off a retroviral vector at 3days after transduction. SMIRNOV_RESPONSE_TO_IR_6HR_DN Genesdown-regulated in B lymphocytes at 6 h 113 −5.489 after exprosure to 10Gy dose of ionizing radiation. WINTER_HYPOXIA_DN Genes down-regulated inhead and neck tumor 52 −5.505 samples which clustered around knownhypoxia genes. HAHTOLA_SEZARY_SYNDROM_DN Genes down-regulated inmonocytes isolated from 38 −5.539 peripheral blood samples of Sezarysyndrome patients compared to those from healthy normal donors.ROSS_AML_WITH_CBFB_MYH11_FUSION Top 63 probe sets for pediatric acutemyeloid 50 −5.565 leukemia (AML) subtype inv(16); has a CBFB- MYH11fusion [GeneID = 865; 4629]. WATANABE_ULCERATIVE_COLITIS_WITH_CANCER_DNGenes down-regulated in non-neoplastic rectal 14 −5.575 mucosa samplesfrom patients having cancer associated with ulcerative collitis,compared to those who did not have the cancer.BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE Genes representing aco-expression network in 143 −5.688 atopic CD4 [GeneID = 920] Tlymphocyte responses. DER_IFN_ALPHA_RESPONSE_UP Genes up-regulated inHT1080 cells 73 −5.851 (fibrosarcoma) by treatment with interferon alphafor 6 h. DAUER_STAT3_TARGETS_DN Top 50 genes down-regulated in A549cells (lung 49 −5.852 cancer) expressing STAT3 [GeneID = 6774] off anadenovirus vector. UROSEVIC_RESPONSE_TO_IMIQUIMOD Interferon clustergenes up-regulated in skin 23 −5.914 tumors treated with imiquimod[PubChem = 57469]. ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP Hepatic graftversus host disease (GVHD), day 7: 101 −6.048 up-regulated in allogeneicvs syngeneic bone marrow transplant. LIANG_SILENCED_BY_METHYLATION_2Genes up-regulated in T24 cells (bladder 51 −6.1 carcinoma) aftertreatment with decitabine (5-aza- 2′-deoxycytidine) [PubChem = 451668].ZHAN_MULTIPLE_MYELOMA_LB_DN Top 50 down-regulated genes in cluster LB of39 −6.128 multiple myeloma samples belonging to the low bone diseasegroup. SMIRNOV_RESPONSE_TO_IR_2HR_DN Genes down-regulated in Blymphocytes at 2 h 55 −6.131 after exprosure to 10 Gy dose of ionizingradiation. PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_DN Genes down-regulated inpost-GC, BCL6 161 −6.177 [GeneID = 604] dependent B cell non-Hodgkin'slymphoma (B-NHL) vs MYC [GeneID = 4609] driven pre-GC lymphoma.TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_DN Genes down-regulated in plasmacells compared 38 −6.207 with B lymphocytes.BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX Genes up-regulated by growingHMEC-E6 cells 17 −6.209 (mammary epithelial cells damaged by expressionof HPV-16 E6 [GeneID = 1489078]) in extracellular matrix (ECM).SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP Genes up-regulated incirculating endothelial cells 155 −6.213 (CEC) from cancer patientscompared to those from healthy donors.GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3 Genes up-regulated in Jurkat cells(T lymphocyte) 13 −6.218 by IFN1@, and IFNB1 [GeneID = 3438; 3456] butnot by overexpression of a constitutively active form of IRF3 [GeneID =3661]. KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS Inflammatory cytokines andtheir receptors 43 −6.354 modulated in brain tumors after treatment withan oncocytic virus, a potential anticancer therapy.TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN Genes down-regulated inCD34+ [GeneID = 947] 130 −6.365 hematopoetic cells by expression ofNUP98- HOXA9 fusion [GeneID = 4928; 3205] off a retroviral vector at 16days after transduction. BROWN_MYELOID_CELL_DEVELOPMENT_UP Genesdefining differentiation potential of the 158 −6.503 bipotential myeloidcell line FDB. TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN Genesdown-regulated in CD34+ [GeneID = 947] 139 −6.513 hematopoetic cells byexpression of NUP98- HOXA9 fusion [GeneID = 4928; 3205] off a retroviralvector at 10 days after transduction. VILIMAS_NOTCH1_TARGETS_UP Genesup-regulated in bone marrow progenitors 51 −6.594 by constitutivelyactive NOTCH1 [GeneID = 4851]. SANA_RESPONSE_TO_IFNG_UP Genesup-regulated in five primary endothelial 75 −6.598 cell types (lung,aortic, iliac, dermal, and colon) by IFNG [GeneID = 3458].BOSCO_INTERFERON_INDUCED_ANTIVIRAL_MODULE Genes representinginterferon-induced antiviral 75 −6.911 module in sputum during asthmaexacerbations. BOSCO_TH1_CYTOTOXIC_MODULE Genes representingTh1/cytotoxic module in 107 −6.961 sputum during asthma exacerbations.CHUNG_BLISTER_CYTOTOXICITY_DN Genes down-regulated in blister cells from44 −7.116 patients with adverse drug reactions (ADR).FARMER_BREAST_CANCER_CLUSTER_1 Cluster 1: interferon, T and B lymphocytegenes 42 −7.281 clustered together across breast cancer samples.MOSERLE_IFNA_RESPONSE Top 50 genes up-regulated in ovarian cancer 30−7.46 progenitor cells (also known as side population, SP, cells) inresponse to interferon alpha (IFNA). ZHENG_FOXP3_TARGETS_IN_THYMUS_UPGenes with promoters bound by FOXP3 187 −7.485 [GeneID = 50943] andwhich are up-regulated only in developing (located in the thymus)regulatory CD4+ [GeneID = 920] T lymphocytes.ALTEMEIER_RESPONSE_TO_LPS_WITH_MECHANICAL_VENTILATION Genes up-regulatedin lung tissue upon LPS 117 −7.638 aspiration with mechanicalventilation (MV) compared to control (PBS aspiration without MV).FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP Genes up-regulatedin kidney biopsies from 83 −7.809 patients with acute transplantrejection compared to the biopsies from patients with well functioningkidneys more than 1-year post transplant. HECKER_IFNB1_TARGETS Genestranscriptionally modulated in the blood of 92 −7.956 multiple sclerosispatients in response to subcutaneous treatment with recombinant IFNB1[GeneID = 3456]. TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN Genesdown-regulated in CD34+ [GeneID = 947] 198 −9.058 hematopoetic cells byexpression of NUP98- HOXA9 fusion [GeneID = 4928; 3205] off a retroviralvector at 8 days after transduction. BROWNE_INTERFERON_RESPONSIVE_GENESGenes up-regulated in primary fibroblast culture 67 −9.279 aftertreatment with interferon alpha for 6 h. LEE_EARLY_T_LYMPHOCYTE_DN Genesdown-regulated at early stages of 55 −9.974 progenitor T lymphocytematuration compared to the late stages. LEE_DIFFERENTIATING_T_LYMPHOCYTEGenes enriched at every T lymphocyte 192 −10.833 differentiation stagecompared to the early passage fetal thymic stromal cultures (TSC).

Table 8 shows the Number of Data Sets

TABLE 8 Number of Data Sets Age-group No. of datasets No. of samples11-12 13 47 12-13 9 35 13-14 8 29 14-15 8 27 15-16 10 27 16-17 10 5117-18 14 74 18-19 17 56 19-20 13 33 20-21 14 40 21-22 16 49 22-23 17 4323-24 14 49 24-25 19 61 25-26 19 51 26-27 18 55 27-28 17 61 28-29 13 5329-30 15 50 30-31 18 49 31-32 17 48 32-33 17 60 33-34 18 73 34-35 17 6435-36 20 73 36-37 21 78 37-38 20 57 38-39 17 46 39-40 20 65 40-41 22 9441-42 18 79 42-43 19 68 43-44 17 69 44-45 23 63 45-46 20 63 46-47 17 5547-48 20 67 48-49 22 82 49-50 26 89

Thus, in certain embodiments, as shown herein, samples are sorted byage, and then hierarchical clustering can be performed to identify setsof genes that are most correlated with older and thus deleteriouseffects, and younger. These genes are candidate biomarkers forreproductive status.

In certain embodiments, predictors of reproductive success can beverified as follows: The genes most associated with pregnancy outcome(both positive and negative) can be tested on a separate sample setprior to IVF treatment to verify predictive power of the gene set. Twoapproaches can be used: one with individual qRT-PCR primers for eachgene, and a second with the entire set of primers.

In a non-limiting Example, the diagnostic application can be implementedas follows: A blood sample from a patient is collected, RT-PCR performedusing the diagnostic primer set, and the profile results matched usingPearson correlation to the reproductive age profile. For example, a32-year old patient might have a blood profile that best matches that ofa 38 year old, indicating that she is reproductively aged relative toher chronological age, and thus might not want to delay childbearingmuch longer. Under current guidelines, older patients might be deniedIVF or other ART treatment, but the tests herein could show that achronologically 43-year old patient might best match that of an average38 year old, and thus would still be a viable candidate for IVF or otherassisted reproductive techniques. Thus, a diagnostic that easily andaccurately correlates a key set of biomarkers with reproductive capacitycan be useful for several applications.

In certain embodiments, the methods herein may be directed to themeasure or determination of oocyte quality based on a combination of twoor more any of the markers discussed herein. For example, adetermination of characteristics of two or more of the genes or pathwaysdiscussed herein can, in certain embodiments, provide a more accurateset of data regarding a subject's oocyte quality and thus her likelihoodof conceiving, than would be the case with only a single gene orpathway.

In certain embodiments, the technology herein contemplates methods orkits that comprise a binding molecule, for example, a bindingcomposition that specifically binds to any protein produced by abiomarker gene discussed herein and may be conjugated to anothermolecule, for example, an enzyme or a molecule that provides a visualindication of oocyte quality of some other detected characteristic ofthe cell.

Although the present technology has been described in relation toparticular embodiments thereof, these embodiments and examples aremerely exemplary and not intended to be limiting. Many other variationsand modifications and other uses will become apparent to those skilledin the art. The present technology should, therefore, not be limited bythe specific disclosure herein, and may be embodied in other forms notexplicitly described here, without departing from the spirit thereof.

I claim:
 1. A method of determining the quality of an oocyte in the bodyof a human without disturbing or destroying the oocyte, the methodcomprising: (a) obtaining a cell sample from a female subject, whereinthe cell sample does not include the oocyte; (b) measuring acharacteristic of a gene or pathway indicative of oocyte quality in thecell sample; and (c) predicting or determining the quality of the oocytebased on the characteristic of the gene or pathway.
 2. The method ofclaim 1, wherein step (b) comprises measuring a gene expression value ofthe cell sample through an RT-PCR assay, an ELISA assay or acolorometric test.
 3. The method of claim 2, wherein step (b) furthercomprises comparing the measured gene expression values to a known geneexpression value of an oocyte with Pearson correlation, or by matchingthe measured gene expression values to a known gene expression profilefrom a library of genes as markers of oocyte quality.
 4. The method ofclaim 1, wherein the cell sample is extracted from blood, skin, hair,urine, saliva, sweat or vaginal secretion.
 5. The method of claim 1,wherein the gene or pathway is chosen from SERPINB2 (serpin peptidaseinhibitor, Glade B, member 2, also known as PAI-2); IGFIR (insulin-likegrowth factor 1 receptor); PIK3CB (phosphoinositide-3-kinase, catalytic,beta polypeptide), IRS2 (insulin receptor substrate 2), HSPA8, HSPD1,HSP60, TGF-β and insulin/IGF-1 (IIS) signaling pathway.
 6. A method ofpredicting the quality of an oocyte in the body of a mammal withoutdisturbing or destroying the oocyte, the method comprising the steps of:(a) obtaining a cell sample from the mammal, wherein the cell sampledoes not include the oocyte; (b) conducting an RT-PCR assay or an ELISAassay on the cell sample using a primer for a gene known to becorrelated with aging, and comparing the result with a known valueobtained from a library of genes known to be correlated with decreasedoocyte quality; and (d) predicting the likelihood of oocyte viabilitybased on (b).
 7. A kit for predicting a woman's oocyte quality withoutthe need for disturbing or destroying an oocyte, the kit comprising: (a)a collection container for collecting a cell sample obtained from thewoman's body, wherein the cell sample does not include an oocyte; (b) atesting assay comprising RT-PCR or ELISA, wherein the testing assaymeasures a characteristic of a gene, pathway or transcriptional profilecharacteristic of the cell sample, and wherein the characteristicindicates the likely quality of an oocyte; and (c) a visual indicatorvisible to the woman, the visual indicator providing informationregarding the predicted quality of the oocyte.
 8. The kit of claim 7,wherein the gene or pathway is chosen from SERPINB2 (serpin peptidaseinhibitor, Glade B, member 2, also known as PAI-2); IGFIR (insulin-likegrowth factor 1 receptor); PIK3CB (phosphoinositide-3-kinase, catalytic,beta polypeptide), IRS2 (insulin receptor substrate 2), HSPA8, HSPD1,HSP60, TGF-β and insulin/IGF-1 (IIS) signaling pathway.
 9. A method ofproducing a library of genes as markers of oocyte quality, the methodcomprising the steps of: (a) gathering expression data from cells ofwomen in a particular age range; (b) calculating an average geneexpression for each gene at each age in the range by averaging theexpression for that gene in a window of a given period of time; (c)comparing the average gene expression of (b) to an “age vector” toindicate which genes change most with age; and (d) calculating a FisherZscore, thereby identifying the genes at the tail ends of thedistribution as indicators of biological age.
 10. The method of claim 9,wherein for one or more of the genes identified in step (d), theSpearmann correlation of the average gene expression to the age vectorwas determined, and then sorted by the FisherZ score.
 11. The method ofclaim 10, wherein the genes for which a score above 2 (top 5%) wascalculated were added to a set of significantly changed age-dependentgenes to comprise the library of genes.
 12. The method of claim 9,further comprising any of the following steps: correlating a test genewith a quantitative and measured characteristic of oocyte quality;listing the correlation in the library; comparing a measuredcharacteristic of a gene provided by a patient with that listed in thelibrary; and determining the quality of an oocyte of a patient based onthe comparison.
 13. A method of developing a reproductive aging geneexpression profile and one or more candidate markers of reproductivesuccess or oocyte quality, the method comprising the steps of claim 9.14. The method of claim 1, wherein the characteristic measured in thecell sample is assigned a score that conveys the expected oocyteviability.
 15. The method of claim 14, wherein the score conveys theexpected oocyte viability compared to an average for women of the sameage as the female subject.